Publication

Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos

Denis Duboule, Alexandre Gauthier Aurèle Mayran, Hocine Rekaik, Célia Corinne Renée Bochaton
2023
Journal Articles

Abstract

Temporal activation of Hox genes in mouse pseudo-embryos in vitro initiates at the anterior part of the cluster and is accompanied by asymmetric loading of cohesin. Posterior CTCF sites then successively act as transient insulators, regulating the timed transcription of more posterior-located genes.

Official source

https://infoscience.epfl.ch/entities/publication/a5cc61fe-b8ec-4fcb-835e-46f6aa4b343d

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Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos

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Ancestral genome reconstruction enhances transposable element annotation by identifying degenerate integrants

Decoding Chromatin Ubiquitylation: A Chemical Biology Perspective

A CTCF-dependent mechanism underlies the Hox timer relation to a segmented body plan