Publications associées à The rise and fall of Hox gene clusters

A CTCF-dependent mechanism underlies the Hox timer relation to a segmented body plan

During gastrulation, Hox genes are activated in a timesequence that follows the order of the genes along their clusters. This property, which is observed in all animals that develop following a progressive rostral-to-caudal morphogenesis, is associated wit ...

Current Biology Ltd2024

Hydrodynamical simulations of merging galaxy clusters: giant dark matter particle colliders, powered by gravity

Richard Massey, David Richard Harvey

Terrestrial particle accelerators collide charged particles, then watch the trajectory of outgoing debris - but they cannot manipulate dark matter. Fortunately, dark matter is the main component of galaxy clusters, which are continuously pulled together by ...

Oxford Univ Press2024

Hidden Gems on a Ring: Infant Massive Clusters and Their Formation Timeline Unveiled by ALMA, HST, and JWST in NGC 3351

Hamid Hassani, Hao He, Robin Gopala Tress, Jiayi Sun

We use 0.1 '' observations from the Atacama Large Millimeter Array (ALMA), Hubble Space Telescope (HST), and JWST to study young massive clusters (YMCs) in their embedded "infant" phase across the central starburst ring in NGC 3351. Our new ALMA data revea ...

Iop Publishing Ltd2024

Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos

Denis Duboule, Célia Corinne Renée Bochaton, Lucille Delisle, Hocine Rekaik, Aurélie Hintermann, Alexandre Gauthier Aurèle Mayran

Temporal activation of Hox genes in mouse pseudo-embryos in vitro initiates at the anterior part of the cluster and is accompanied by asymmetric loading of cohesin. Posterior CTCF sites then successively act as transient insulators, regulating the timed tr ...

NATURE PORTFOLIO2023

A new step forward in realistic cluster lens mass modelling: analysis of Hubble Frontier Field Cluster Abell S1063 from joint lensing, X-ray, and galaxy kinematics data

Johan Richard, Jean-Paul Richard Kneib, Mathilde Jauzac, Benjamin Yvan Alexandre Clement, Benjamin Emmanuel Nicolas Beauchesne

We present a new method to simultaneously and self-consistently model the mass distribution of galaxy clusters that combines constraints from strong lensing features, X-ray emission, and galaxy kinematics measurements. We are able to successfully decompose ...

Oxford Univ Press2023

The evolution of the Milky Way's thin disc radial metallicity gradient with K2 asteroseismic ages

Saniya Khan

The radial metallicity distribution of the Milky Way's disc is an important observational constraint for models of the formation and evolution of our Galaxy. It informs our understanding of the chemical enrichment of the Galactic disc and the dynamical pro ...

Oxford Univ Press2023

The Local Cluster Survey II: disc-dominated cluster galaxies with suppressed star formation

Pascale Jablonka

We investigate the role of dense environments in suppressing star formation by studying log(10)(M- * / M-?) > 9 . 7 star-forming galaxies in nine clusters from the Local Cluster Survey (0.0137 < z < 0.0433) and a large comparison field sample drawn from th ...

OXFORD UNIV PRESS2023

Elastocapillary menisci mediate interaction of neighboring structures at the surface of a compliant solid

John Martin Kolinski

Surface stress drives long-range elastocapillary interactions at the surface of compliant solids, where it has been observed to mediate interparticle interactions and to alter the transport of liquid drops. We show that such an elastocapillary interaction ...

2023

Systematic analysis of low-affinity transcription factor binding site clusters in vitro and in vivo establishes their functional relevance

Sebastian Maerkl, Ivan Istomin, Evan James Olson, Shiyu Cheng, Amir Shahein, Maria Lopez Malo

Binding to binding site clusters has yet to be characterized in depth, and the functional relevance of low-affinity clusters remains uncertain. We characterized transcription factor binding to low-affinity clusters in vitro and found that transcription fac ...

Nature Portfolio2022

Do the majority of stars form as gravitationally unbound?

Richard Irving Anderson

Context. Some of the youngest stars (age less than or similar to 10 Myr) are clustered, while many others are observed scattered throughout star forming regions or in complete isolation. It has been intensively debated whether such scattered or isolated st ...

2022

Binary Perceptron: Efficient Algorithms Can Find Solutions in a RareWell-Connected Cluster

Emmanuel Abbé

It was recently shown that almost all solutions in the symmetric binary perceptron are isolated, even at low constraint densities, suggesting that finding typical solutions is hard. In contrast, some algorithms have been shown empirically to succeed in fin ...

ASSOC COMPUTING MACHINERY2022

Geographic clusters of objectively measured physical activity and the characteristics of their built environment in a Swiss urban area

Stéphane Joost, Cédric Gubelmann, Marco André Vieira Ruas, Idris Guessous

Introduction ...

PUBLIC LIBRARY SCIENCE2022

The standard operating procedure for Airmodus Particle Size Magnifier and nano-Condensation Nucleus Counter

Lubna Dada

Measurements of aerosol particles and clusters smaller than 3 nm in diameter are performed by many groups in order to detect recently formed or emitted nanoparticles and for studying the formation and early growth processes of aerosol particles. The Airmod ...

2022

Subspace clustering in high-dimensions: Phase transitions & Statistical-to-Computational gap

Florent Gérard Krzakala, Lenka Zdeborová, Bruno Loureiro, Luca Pesce, Bruno Loureiro

A simple model to study subspace clustering is the high-dimensional k -Gaussian mixture model where the cluster means are sparse vectors. Here we provide an exact asymptotic characterization of the statistically optimal reconstruction error in this model i ...

2022

A stellar stream remnant of a globular cluster below the metallicity floor

Pascale Jablonka, Carmela Lardo

Stellar ejecta gradually enrich the gas out of which subsequent stars form, making the least chemically enriched stellar systems direct fossils of structures formed in the early Universe(1). Although a few hundred stars with metal content below 1,000th of ...

NATURE PORTFOLIO2022

Feasibility of Detecting Interstellar Panspermia in Astrophysical Environments

Claudio Grimaldi

The proposition that life can spread from one planetary system to another (interstellar panspermia) has a long history, but this hypothesis is difficult to test through observations. We develop a mathematical model that takes parameters such as the microbi ...

IOP PUBLISHING LTD2021

CODEX weak lensing mass catalogue and implications on the mass-richness relation

Jean-Paul Richard Kneib, Huanyuan Shan

The COnstrain Dark Energy with X-ray clusters (CODEX) sample contains the largest flux limited sample of X-ray clusters at 0.35 < z < 0.65. It was selected from ROSAT data in the 10 000 square degrees of overlap with BOSS, mapping a total number of 2770 hi ...

OXFORD UNIV PRESS2021

Size and duration of COVID-19 clusters go along with a high SARS-CoV-2 viral load: A spatio-temporal investigation in Vaud state, Switzerland

Séverine Vuilleumier Varisco, Stéphane Joost, Onya Opota, Anaïs Laurence Ladoy, Idris Guessous

To understand the geographical and temporal spread of SARS-CoV-2 during the first documented wave of infection in the state of Vaud, Switzerland, we analyzed clusters of positive cases using the precise residential location of 33,651 individuals tested (RT ...

2021

Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster

Denis Duboule, Leonardo Beccari, Lucille Delisle, Jozsef Zakany

In this study, Amandio et al. sought to understand the functions of the highly conserved CTCF sites distributed over the Hox gene clusters. The authors produced an allelic series of cumulative in cis mutations in these sites, up to the abrogation of CTCF b ...

COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT2021

The accreted nuclear clusters of the Milky Way

Carmela Lardo

A number of the massive clusters in the halo, bulge, and disc of the Galaxy are not genuine globular clusters (GCs) but instead are different beasts altogether. They are the remnant nuclear star clusters (NSCs) of ancient galaxies since accreted by the Mil ...

OXFORD UNIV PRESS2021