Hybrid Polymer Therapeutics Incorporating Bioresponsive, Coiled Coil Peptide Linkers

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stk-search employs multiple search algorithms, including Bayesian optimization, to systematically navigate the chemical space of molecules constructed from modular building blocks. ...

The phenomenon of allostery, a general property in proteins that has been heralded as "the second secret of life" remains elusive to our understanding and even more challenging to incorporate into protein design. One example of allosteric proteins with gre ...

Newer solid-phase peptide synthesis and release strategies enable the production of short peptides with high purity, allowing direct screening for desired bioactivity without prior chromatographic purification. However, the maximum number of peptides that ...

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Macrocycles provide an attractive modality for drug development, but generating ligands for new targets is hampered by the limited availability of large macrocycle libraries. We have established a solution-phase macrocycle synthesis strategy in which three ...

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G protein-coupled receptors play essential roles in cellular processes such as neuronal signaling, vision, olfaction, tasting, and metabolism. As GPCRs are the most important drug targets, understanding their interactions with ligands is of utmost importan ...

Hybrid Polymer Therapeutics Incorporating Bioresponsive, Coiled Coil Peptide Linkers

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Comparative analysis of search approaches to discover donor molecules for organic solar cells

From Sequence to Dynamics to Function: Computational Design of Allostery and Ligand Selectivity in G-Protein Coupled Receptors

Solid-phase peptide synthesis in 384-well plates

Computational drug development for membrane protein targets

Cyclic Peptides for Drug Development

Opportunities and challenges in design and optimization of protein function

A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers

The predictive capacity of in vitro preclinical models to evaluate drugs for the treatment of retinoblastoma

Peptide-Hypervalent Iodine Reagent Chimeras: Enabling Peptide Functionalization and Macrocyclization

On-Demand Cross-Linkable Bottlebrush Polymers for Voltage- Driven Artificial Muscles

Optimised three-dimensional in vitro retinoblastoma models tailored for drug discovery and clinical translatability

Generating macrocyclic inhibitors of protein-protein interactions

A generic framework for hierarchical de novo protein design

Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway

In-Cell Quantification of Drugs by Magic-Angle Spinning Dynamic Nuclear Polarization NMR

Repurposed drug combination via high-throughput screening and dual drug delivery system development for the treatment of retinoblastoma

Macrocycle synthesis strategy based on step-wise “adding and reacting” three components enables screening of large combinatorial libraries

Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern

Experimental And Theoretical Insight Into Formulations Based On Poly(Vinyl Alcohol Boric Acid) And Diclofenac Sodium Salt

Enhancing the Signaling of GPCRs via Orthosteric Ions