Modeling and performance investigation of insulin injection pen for diabetic persons

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Microtubules serve as tracks for long-range intracellular trafficking of glucose transporter 4 (GLUT4), but the role of this process in skeletal muscle and insulin resistance is unclear. Here, we used fixed and live-cell imaging to study microtubule-based ...

The neural stimulation of the vagus nerve is able to modulate various functions of the parasympathetic response in different organs. The stimulation of the vagus nerve is a promising approach to treating inflammatory diseases, obesity, diabetes, heart fail ...

Pancreatic beta cells play a major role in the regulation of glucose homeostasis by secreting insulin in response to elevated blood glucose levels. A gradual deterioration of functional beta cell mass and the chronic elevation of blood glucose levels are c ...

Neonatal and juvenile porcine islet cell clusters (ICC) present an unlimited source for islet xenotransplantation to treat type 1 diabetes patients. We isolated ICC from pancreata of 14 days old juvenile piglets and characterized their maturation by immuno ...

Sirtuin 3 (SIRT3) is a protein deacetylase regulating beta-cell function through inhibiting oxidative stress in obese and diabetic mice, but the detailed mechanism and potential effect of beta-cell-specific SIRT3 on metabolic homeostasis, and its potential ...

Hypoglycemia is critical condition during diabetic treatment that involves intensive insulin therapy, and it may impair brain function. We aimed to compare cortical responses of three hypoglycemic phases and the restoration of glycemia to control levels af ...

Women with intrahepatic cholestasis of pregnancy (ICP), a disorder characterised by raised serum bile acids, are at increased risk of developing gestational diabetes mellitus and have impaired glucose tolerance whilst cholestatic. FXR and TGR5 are modulato ...

Pancreatic beta-cells secrete insulin to lower blood glucose, following a meal. Maintenance of beta-cell function is essential to preventing type 2 diabetes. In pancreatic beta-cells, mitochondrial matrix calcium is an activating signal for insulin secreti ...

Aims/hypothesis In islets from individuals with type 2 diabetes and in islets exposed to chronic elevated glucose, mitochondrial energy metabolism is impaired. Here, we studied early metabolic changes and mitochondrial adaptations in human beta cells durin ...

Circadian clocks operative in pancreatic islets participate in the regulation of insulin secretion in humans and, if compromised, in the development of type 2 diabetes (T2D) in rodents. Here we demonstrate that human islet alpha- and beta-cells that bear a ...

Magnetorheological (MR) fluids are materials characterized as “intelligent” since their rheological properties may be controlled by the excitation of an external magnetic field. The application of the latter brings the fluid from a liquid to a semi-solid s ...

A fully parameterized three-dimensional model with specific dimensions has been developed in ANSYS for an insulin injection pen used by diabetic persons. The insulin injection pen has a smart pen cap which hosts four electrodes used for the smart pen cap e ...

A low-power 14-bits first order incremental Analog-to-Digital Converter (ADC) is presented. Based on the charge balancing principle, this switched-capacitor (SC) circuit integrates the input signal multiple times to reach the targeted resolution, linearity ...

Glucose transporter 2 (Glut2)-positive cells are sparsely distributed in brain and play an important role in the stimulation of glucagon secretion in response to hypoglycemia. We aimed to determine if Glut2-positive cells can influence another response to ...

Overactivity of the sympathetic nervous system (SNS) is associated to several cardiovascular and metabolic dysfunctions, such as hypertension and insulin resistance. Indirect biochemical measurements and surgical manipulations have provided preliminary evi ...

N-acetylaspartate (NAA) is synthesized by aspartate N-acetyltransferase (gene: Nat8l) from acetyl-coenzyme A and aspartate. In the brain, NAA is considered an important energy metabolite for lipid synthesis. However, the role of NAA in peripheral tissues r ...

A bio-electronics system that measures cytosolic [Ca2+] in vitro in the INS-1E pancreatic beta-cells using a 430 nm excitation light with the excitation wavelength of the probe being at 435 nm was successfully implemented and tested. We transfected the INS ...

Glucose sensing and regulation of insulin secretion are the two main functions performed by the pancreatic beta-cell. Together these processes contribute to the tight control of blood glucose in our body. Compromising the ability of the beta-cells to prope ...

Recent studies showed that the carotid sinus nerve (CSN) and the sympathetic nervous system (SNS) are overactivated in type 2 diabetes and that restoring the correct CSN neural activity can re-establish the proper metabolism. However, a robust characteriza ...

Reduced mitochondria! electron transport chain activity promotes longevity and improves energy homeostasis via cell-autonomous and non-autonomous factors in multiple model systems. This mitohormetic effect is thought to involve the mitochondrial unfolded p ...

Modeling and performance investigation of insulin injection pen for diabetic persons

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Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle

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Multipotent mesenchymal stromal cells derived from porcine exocrine pancreas improve insulin secretion from juvenile porcine islet cell clusters

Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity

Metabolic and perfusion responses to acute hypoglycemia in the rat cortex: A non-invasive magnetic resonance approach

Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis

Targeting Mitochondrial Calcium Uptake with the Natural Flavonol Kaempferol, to Promote Metabolism/Secretion Coupling in Pancreatic beta-cells

Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells

In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis

Design optimization of Miniature Magnetorheological Valves with Self-Sensing Capabilities Used for a Wearable Medical Application

Three-Dimensional Model and Evaluation of an Insulin Injection Pen for Precise Dose Capacitive Measurement

A high sensitivity low-power capacitive front-end for insulin injection pens

Glucose transporter 2 mediates the hypoglycemia-induced increase in cerebral blood flow

High frequency shift in Carotid Sinus Nerve and Sympathetic Nerve activity in Type 2 Diabetic Rat Model

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

Pancreatic beta cell based optical biosensor and system for continuous glucose monitoring

Role of metabolism and mitochondria during glucose sensing and glucose-induced dysfunction in human pancreatic beta-cells

Decoding Neural Metabolic Markers From the Carotid Sinus Nerve in a Type 2 Diabetes Model

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis