Modeling and performance investigation of insulin injection pen for diabetic persons

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Pancreatic islets (PIs) transplantation is an alternative approach for the treatment of severe forms of type 1 diabetes (T1D). To monitor the success of transplantation, it is desirable to follow the location of engrafted PIs non-invasively. In vivo magnet ...

Insulin resistance is a major predictor of the development of metabolic disorders. Sirtuins (SIRTs) have emerged as potential targets that can be manipulated to counteract age-related diseases, including type 2 diabetes. SIRT2 has been recently shown to ex ...

Glucose uptake in muscle cells in response to insulin is a fundamental mechanism for metabolism. The inability of cells to mobilize the specific glucose transporter GLUT4 is believed to be at least partially accountable for diseases, like diabetes, where c ...

Complex events are instrumental in understanding advanced behaviours and properties of a system. They can represent more meaningful events as compared to simple events. In this thesis we propose to use wearable sensor signals to detect complex events. Thes ...

Mitochondrial fusion and fission events, collectively known as mitochondrial dynamics, act as quality control mechanisms to ensure mitochondrial function and fine-tune cellular bioenergetics. Defective mitofusin 2 (Mfn2) expression and enhanced mitochondri ...

Diabetes Type 1 is a metabolic disease which results in a lack of insulin production, causing high glucose levels in the blood. It is crucial for diabetic patients to balance this glucose level, and they depend on external substances to do so. In order to ...

This thesis has been put in place during the development of an innovative medical device which consists in an intelligent footwear for foot plantar pressure redistribution in diabetic patients. In fact, despite the several sophisticated techniques develope ...

Glutathione (GSH) deficits have been observed in several mental or degenerative illness, and so has the metabolic syndrome. The impact of a decreased glucose metabolism on the GSH system is well-known, but the effect of decreased GSH levels on the energy m ...

Background: Multipotent mesenchymal stromal cells (MSC) enhance viability and function of islets of Langerhans. We aimed to examine the interactions between human MSC and human islets of Langerhans that influence the function of islets. Methods: Human MSC ...

Ectopic lipid accumulation in the liver is implicated in metabolic disease in an age- and sex-dependent manner. The role of hepatic lipids has been well established within the scope of metabolic insults in mice, but has been insufficiently characterized un ...

Caloric restriction (CR) has been shown to prevent the onset of insulin resistance and to delay age-related physiological decline in mammalian organisms. SIRT1, a NAD(+) -dependent deacetylase enzyme, has been suggested to mediate the adaptive responses to ...

Modeling and performance investigation of insulin injection pen for diabetic persons

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Improved Labeling of Pancreatic Islets Using Cationic Magnetoliposomes

The NAD(+)-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes

A multiscale study of the role of dynamin in the regulation of glucose uptake

Complex event recognition through wearable sensors

Mfn2 is critical for brown adipose tissue thermogenic function

Semantic representation and processing of hypoglycemic events derived from wearable sensor data

Design, Modelling and Sensing Possibilities of Magneto-Rheological Based Devices

Glutamate Cysteine Ligase-Modulatory Subunit Knockout Mouse Shows Normal Insulin Sensitivity but Reduced Liver Glycogen Storage

Multipotent mesenchymal stromal cells enhance insulin secretion from human islets via N-Cadherin interaction and prolong function of transplanted encapsulated islets in mice

Sexual dimorphism in hepatic lipids is associated with the evolution of metabolic status in mice

SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting