Hypothalamic deep brain stimulation augments walking after spinal cord injury

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The premotor (PM) and primary motor (M1) cortical areas broadcast voluntary motor commands through multiple neuronal pathways, including the corticorubral projection that reaches the red nucleus (RN). However, the respective contribution of M1 and PM to co ...

Objective. Peripheral nerve interfaces have the potential to restore sensory, motor, and visceral functions. In particular, intraneural interfaces allow targeting deep neural structures with high selectivity, even if their performance strongly depends upon ...

Goal-directed behaviors involve coordinated activity in many cortical areas, but whether the encoding of task variables is distributed across areas or is more specifically represented in distinct areas remains unclear. Here, we compared representations of ...

The functional organization of neural processes is constrained by the brain's intrinsic structural connectivity, i.e., the connectome. Here, we explore how structural connectivity can improve the representation of brain activity signals and their dynamics. ...

Retinal prostheses can restore a functional form of vision in patients affected by dystrophies of the outer retinal layer. Beyond clinical utility, prostheses for the stimulation of the optic nerve, the visual thalamus or the visual cortex could also serve ...

Auditory brainstem implants (ABIs) provide sound awareness to deaf individuals who are not candidates for the cochlear implant. The ABI electrode array rests on the surface of the cochlear nucleus (CN) in the brainstem and delivers multichannel electrical ...

The brain is the substrate of a complex dynamic system providing a remarkably varied range of functionalities, going from simple perception to higher-level cognition. Disturbances in its complex dynamics can cause an equally vast variety of mental disorder ...

Mammalian motor control is implemented by a combination of different networks and system, working coherently to plan the movement of the body or a limb and to execute this movement a dynamical environment. While it is believed that complex, voluntary movem ...

Impaired locomotion is a frequent and major source of disability in patients with neurological conditions. Different neuroimaging methods have been used to understand the brain substrates of locomotion in various neurological diseases (mainly in Parkinson' ...

Despite many behavioral and neuroimaging investigations, it remains unclear how the human cortex represents spectrotemporal sound features during auditory imagery, and how this representation compares to auditory perception. To assess this, we recorded ele ...

Objective. The vestibular system provides essential information about balance and spatial orientation via the brain to other sensory and motor systems. Bilateral vestibular loss significantly reduces quality of life, but vestibular implants (VIs) have demo ...

The electroencephalogram (EEG) is a non-invasive and low-cost tool for the investigation of human brain function. However, EEG data are typically contaminated with a number of artifacts. With the advent of both high-density EEG arrays and studies of large ...

This chapter focuses on valuation in the context of choice under uncertainty. When valuation is a pursuit distinct from choice, values revealed through choice may be different from the valuations that emerge from the (choice-independent) computations. In m ...

Velo-cardio-facial syndrome (VCFS) has been in the focus of intensive research over the last 15 years. The syndrome represents a homogeneous model for studying the effect of a decreased dosage of genes on the development of brain structure and function and ...

Hypothalamic deep brain stimulation augments walking after spinal cord injury

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Loss of Motor Cortical Inputs to the Red Nucleus after CNS Disorders in Nonhuman Primates

Combining biophysical models and machine learning to optimize implant geometry and stimulation protocol for intraneural electrodes

Distributed and specific encoding of sensory, motor, and decision information in the mouse neocortex during goal-directed behavior

The connectome spectrum as a canonical basis for a sparse representation of fast brain activity

Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve

Microstructured thin-film electrode technology enables proof of concept of scalable, soft auditory brainstem implants

Dynamic organization of human brain function and its relevance for psychosis vulnerability

Reverse engineering the motor control system

Brain imaging of locomotion in neurological conditions

Neural encoding of auditory features during music perception and imagery

Characterization of pulse amplitude and pulse rate modulation for a human vestibular implant during acute electrical stimulation

A novel automatic pre-processing pipeline for EEG analysis based on robust statistics

The Neurobiological Foundations of Valuation in Human Decision Making under Uncertainty

Genes, Brain Development and Psychiatric Phenotypes in Velo-Cardio-Facial Syndrome