A design of experiment approach for efficient multi-parametric drug testing using a Caenorhabditis elegans model

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How can we discern whether the covariance operator of a stochastic pro-cess is of reduced rank, and if so, what its precise rank is? And how can we do so at a given level of confidence? This question is central to a great deal of methods for functional dat ...

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The shear stiffness of headed stud connector is a critical parameter for the calculation of deflection and inter-facial shear force for steel-concrete composite structure. Thus, this study presented a promising data-driven model auto-tuning Deep Forest (AT ...

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Over the last few decades, proteins and peptides have become increasingly more common as FDA-approved drugs, despite their inefficient delivery due to their inability to cross the plasma membrane. In this context, bacterial two-component systems, termed AB ...

A design of experiment approach for efficient multi-parametric drug testing using a Caenorhabditis elegans model

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In-Cell Quantification of Drugs by Magic-Angle Spinning Dynamic Nuclear Polarization NMR

Testing For The Rank Of A Covariance Operator

Generating macrocyclic inhibitors of protein-protein interactions

Can Precision Electrophile Signaling Make a Meaningful and Lasting Impression in Drug Design?

Combi-seq for multiplexed transcriptome-based profiling of drug combinations using deterministic barcoding in single-cell droplets

Auto-tuning deep forest for shear stiffness prediction of headed stud connectors

Full-scale testing of European steel beams with reduced beam section under reversed cyclic loading

NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism

Therapeutic approaches against coronaviruses acute respiratory syndrome

Drug-to-Antibody Ratio Estimation via Proteoform Peak Integration in the Analysis of Antibody-Oligonucleotide Conjugates with Orbitrap Fourier Transform Mass Spectrometry

Group testing for connected communities

Harnessing the Membrane Translocation Properties of AB Toxins for Therapeutic Applications