A design of experiment approach for efficient multi-parametric drug testing using a Caenorhabditis elegans model

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The determination of intracellular drug concentrations can provide a better understanding of the drug function and efficacy. Ideally, this should be performed nondestructively, with no modification of either the drug or the target, and with the capability ...

How can we discern whether the covariance operator of a stochastic pro-cess is of reduced rank, and if so, what its precise rank is? And how can we do so at a given level of confidence? This question is central to a great deal of methods for functional dat ...

Protein-protein interactions (PPIs) play important roles in many diseases and their modulation is an attractive strategy for developing new therapeutics. However, the relatively large and often flat binding surfaces of PPIs makes the development of inhibit ...

For several years, drugs with reactive electrophilic appendages have been developed. These units typically confer prolonged residence time of the drugs on their protein targets, and may assist targeting shallow binding sites and/or improving the drug-prote ...

Anti-cancer therapies often exhibit only short-term effects. Tumors typically develop drug resistance causing relapses that might be tackled with drug combinations. Identification of the right combination is challenging and would benefit from high-content, ...

The shear stiffness of headed stud connector is a critical parameter for the calculation of deflection and inter-facial shear force for steel-concrete composite structure. Thus, this study presented a promising data-driven model auto-tuning Deep Forest (AT ...

Steel beams with reduced beam section (RBS) are often used as part of prequalified connections in seismic regions. However, RBS connections are not as common in Europe. Reasons relate to easiness in fabrication, which requires on-site welding, and the seis ...

The discovery of a drug requires over a decade of intensive research and financial investments – and still has a high risk of failure. To reduce this burden, we developed the NICEdrug.ch resource, which incorporates 250,000 bioactive molecules, and studied ...

Coronaviruses represent global health threat. In this century, they have already caused two epidemics and one serious pandemic. Although, at present, there are no approved drugs and therapies for the treatment and prevention of human coronaviruses, several ...

The therapeutic efficacy and pharmacokinetics of antibody-drug conjugates (ADCs) in general, and antibody-oligonucleotide conjugates (AOCs) in particular, depend on the drug-to-antibody ratio (DAR) distribution and average value. The DAR is considered a cr ...

In this paper, we propose algorithms that leverage a known community structure to make group testing more efficient. We consider a population organized in disjoint communities: each individual participates in a community, and its infection probability depe ...

Over the last few decades, proteins and peptides have become increasingly more common as FDA-approved drugs, despite their inefficient delivery due to their inability to cross the plasma membrane. In this context, bacterial two-component systems, termed AB ...

A design of experiment approach for efficient multi-parametric drug testing using a Caenorhabditis elegans model

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In-Cell Quantification of Drugs by Magic-Angle Spinning Dynamic Nuclear Polarization NMR

Testing For The Rank Of A Covariance Operator

Generating macrocyclic inhibitors of protein-protein interactions

Can Precision Electrophile Signaling Make a Meaningful and Lasting Impression in Drug Design?

Combi-seq for multiplexed transcriptome-based profiling of drug combinations using deterministic barcoding in single-cell droplets

Auto-tuning deep forest for shear stiffness prediction of headed stud connectors

Full-scale testing of European steel beams with reduced beam section under reversed cyclic loading

NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism

Therapeutic approaches against coronaviruses acute respiratory syndrome

Drug-to-Antibody Ratio Estimation via Proteoform Peak Integration in the Analysis of Antibody-Oligonucleotide Conjugates with Orbitrap Fourier Transform Mass Spectrometry

Group testing for connected communities

Harnessing the Membrane Translocation Properties of AB Toxins for Therapeutic Applications