Publications related to The bile acid receptor TGR5 regulates the hematopoietic support capacity of the bone marrow niche

Related publications (5)

An autologous antigen-agnostic dendritic cell therapy that forgoes antigen loading

We developed a method for generating dendritic cell progenitors (DCPs) from hematopoietic stem and progenitor cells isolated from bone marrow or blood. When engineered to express IL-12 and FLT3L, these DCPs reprogram the tumor microenvironment and elicit a ...

Nature Portfolio2024

Primate-specific transposable elements shape transcriptional networks during human development

Christopher James Playfoot, Matthias Lütolf, Didier Trono, Julien Léonard Duc, Sandra Eloise Kjeldsen, Evaristo Jose Planet Letschert, Cyril David Son-Tuyên Pulver, Julien Paul André Pontis, Delphine Yvette L Grun, Andrea Manfrin

The human genome harbors more than 4.5 million transposable element (TE)-derived insertions, the result of recurrent waves of invasion and internal propagation. Here they show that TEs belonging to evolutionarily recent subfamilies go on to regulate later ...

Nature Portfolio2022

Modeling hematopoietic stem cell dynamics in bioengineered niches

Sonja Giger

Bone marrow transplantation is a well-established medical procedure for the treatment of various hematologic diseases. However, the relatively low number of hematopoietic stem cells (HSCs) that can be harvested, especially from umbilical cord blood, limits ...

EPFL2019

A feeder-free, defined three-dimensional polyethylene glycol-based extracellular matrix niche for culture of human embryonic stem cells

Jeffrey Alan Hubbell, Jinhyun Kim

We report optimization of a serum- and feeder-free, three-dimensional (3D) niche created with a synthetic polyethylene glycol (PEG)-based extracellular matrix for self-renewal of human embryonic stem cells (hESCs). Three hESC lines (H9, H1 and Novo) were c ...

Elsevier Sci Ltd2013

The stream of precursors that colonizes the thymus proceeds selectively through the early T lineage precursor stage of T cell development

Freddy Radtke

T cell development in the thymus depends on continuous colonization by hematopoietic precursors. Several distinct T cell precursors have been identified, but whether one or several independent precursor cell types maintain thymopoiesis is unclear. We have ...

2008