Publication

An autologous antigen-agnostic dendritic cell therapy that forgoes antigen loading

Michele De Palma
2024
Journal Articles

Abstract

We developed a method for generating dendritic cell progenitors (DCPs) from hematopoietic stem and progenitor cells isolated from bone marrow or blood. When engineered to express IL-12 and FLT3L, these DCPs reprogram the tumor microenvironment and elicit anti-tumor immunity without the need for ex vivo antigen loading.

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An autologous antigen-agnostic dendritic cell therapy that forgoes antigen loading

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