Publication

Primate-specific transposable elements shape transcriptional networks during human development

Matthias Lütolf, Didier Trono, Evaristo José Planet Letschert, Julien Léonard Duc, Sandra Eloise Kjeldsen, Julien Paul André Pontis, Cyril David Son-Tuyên Pulver, Delphine Yvette L Grun, Andrea Manfrin, Christopher James Playfoot
2022
Journal Articles

Abstract

The human genome harbors more than 4.5 million transposable element (TE)-derived insertions, the result of recurrent waves of invasion and internal propagation. Here they show that TEs belonging to evolutionarily recent subfamilies go on to regulate later stages of human embryonic development, notably conditioning the expression of genes involved in gastrulation and early organogenesis.

Official source

https://infoscience.epfl.ch/entities/publication/79285d2c-fc36-4f1e-85b2-1b3b43cc98be

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Primate-specific transposable elements shape transcriptional networks during human development

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