Publications related to Three-Dimensional Model and Evaluation of an Insulin Injection Pen for Precise Dose Capacitive Measurement

Related publications (47)

FAIR data-the photon and neutron communities move together towards open science

The topic of data storage, traceability, and data use and reuse in the years following experiments is becoming an important topic in Europe and across the world. Many scientific communities are striving to create open data by the FAIR principles. This is a ...

2025

In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis

Daniel Sage

Circadian clocks operative in pancreatic islets participate in the regulation of insulin secretion in humans and, if compromised, in the development of type 2 diabetes (T2D) in rodents. Here we demonstrate that human islet alpha- and beta-cells that bear a ...

National Academy of Sciences2020

Efficient Lung Nodule Detection via 3D Deep Learning with Shifted Convolutions

Jiancheng Yang

The high computational costs of deep convolutional neural networks hinder their deployment in real-world applications, including pulmonary nodule detection from CT scans where large 3D image sizes amplify the issue. This paper presents a novel 3D method to ...

IEEE2023

User assessment of fabric shading devices with a low openness factor

Marilyne Andersen, Jan Wienold, Caroline Karmann, Krishna Manwani

Providing adequate glare protection and a view to the outside through fabric shading devices is challenging because these two objectives require conflicting material properties for a fully lowered shading. In a semi -controlled office-like experiment invol ...

2023

Metabolic and perfusion responses to acute hypoglycemia in the rat cortex: A non-invasive magnetic resonance approach

Rolf Gruetter, Hongxia Lei

Hypoglycemia is critical condition during diabetic treatment that involves intensive insulin therapy, and it may impair brain function. We aimed to compare cortical responses of three hypoglycemic phases and the restoration of glycemia to control levels af ...

Wiley-Blackwell2020

Toward higher-performance bionic limbs for wider clinical use

Silvestro Micera

Most prosthetic limbs can autonomously move with dexterity, yet they are not perceived by the user as belonging to their own body. Robotic limbs can convey information about the environment with higher precision than biological limbs, but their actual perf ...

NATURE RESEARCH2023

Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells

Loïc Dayon, Andreas Wiederkehr, Isabelle Chareyron

Aims/hypothesis In islets from individuals with type 2 diabetes and in islets exposed to chronic elevated glucose, mitochondrial energy metabolism is impaired. Here, we studied early metabolic changes and mitochondrial adaptations in human beta cells durin ...

2020

Generalizing Bulk-Synchronous Parallel Processing for Data Science: From Data to Threads and Agent-Based Simulations

Zilu Tian

Agent-based simulations have been widely applied in many disciplines, by scientists and engineers alike. Scientists use agent-based simulations to tackle global problems, including alleviating poverty, reducing violence, and predicting the impact of pandem ...

EPFL2023

Modeling and performance investigation of insulin injection pen for diabetic persons

Catherine Dehollain, Maria-Alexandra Paun

This paper is focused on modeling and performance investigation of insulin injection pens used by diabetic persons. A smart pen cap with two electrodes is used as a capacitive sensor for insulin dose detection and is presented in details. To faithfully ana ...

IEEE2019

A high sensitivity low-power capacitive front-end for insulin injection pens

Maher Kayal, François Krummenacher, Jean-Baptiste Robert Orhan, François Pierre Gaugaz

A low-power 14-bits first order incremental Analog-to-Digital Converter (ADC) is presented. Based on the charge balancing principle, this switched-capacitor (SC) circuit integrates the input signal multiple times to reach the targeted resolution, linearity ...

ELSEVIER SCI LTD2019

Topology Optimization of an Electromagnet Manipulator for 3D Uniform Magnetic Field

Yves Perriard, Adrien Jean-Michel Thabuis, Xiaotao Ren

Magnetic manipulation is a method used for biomedical applications to remotely control micro-robots in a contactless manner. The electromagnet manipulator should control a magnetic field with 3 degrees of freedom inside a region of interest. In various cas ...

IEEE2022

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

Johan Auwerx, Dina Hofer

N-acetylaspartate (NAA) is synthesized by aspartate N-acetyltransferase (gene: Nat8l) from acetyl-coenzyme A and aspartate. In the brain, NAA is considered an important energy metabolite for lipid synthesis. However, the role of NAA in peripheral tissues r ...

2019

Glucose transporter 2 mediates the hypoglycemia-induced increase in cerebral blood flow

Rolf Gruetter, Hongxia Lei

Glucose transporter 2 (Glut2)-positive cells are sparsely distributed in brain and play an important role in the stimulation of glucagon secretion in response to hypoglycemia. We aimed to determine if Glut2-positive cells can influence another response to ...

2019

Wasserstein-Based Graph Alignment

Pascal Frossard, Mireille El Gheche, Hermina Petric Maretic

A novel method for comparing non-aligned graphs of various sizes is proposed, based on the Wasserstein distance between graph signal distributions induced by the respective graph Laplacian matrices. Specifically, a new formulation for the one-to-many graph ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

Mechanistic modelling of solar disinfection (SODIS) kinetics of Escherichia coli, enhanced with H2O2 - part 1: The dark side of peroxide

César Pulgarin, Stefanos Giannakis

The present bi-partite work describes the development and validation of a mechanistic kinetic model of SODIS E. coli inactivation, enhanced with H2O2. In this first part, the mechanism of the baseline dark phenomena is modelled. A mechanistic model involvi ...

ELSEVIER SCIENCE SA2022

Role of metabolism and mitochondria during glucose sensing and glucose-induced dysfunction in human pancreatic beta-cells

Isabelle Chareyron

Glucose sensing and regulation of insulin secretion are the two main functions performed by the pancreatic beta-cell. Together these processes contribute to the tight control of blood glucose in our body. Compromising the ability of the beta-cells to prope ...

EPFL2019

On Succinct Non-interactive Arguments in Relativized Worlds

Alessandro Chiesa

Succinct non-interactive arguments of knowledge (SNARKs) are cryptographic proofs with strong efficiency properties. Applications of SNARKs often involve proving computations that include the SNARK verifier, a technique called recursive composition. Unfort ...

SPRINGER INTERNATIONAL PUBLISHING AG2022

Modeling of a capacitive sensor dedicated to drug injection

Catherine Dehollain

to follow up patients who inject themselves insulin with injection pen is a quite complex task. Due to the repetition of injections, and the numerous influent parameter the patient can easily made an injection mistake and it is difficult for health-takers ...

IEEE2018

Sexual dimorphism in hepatic lipids is associated with the evolution of metabolic status in mice

Rolf Gruetter, Ana Francisca Leal Silva Soares, Hongxia Lei, Marc Moniatte, Jonathan Paz Montoya

Ectopic lipid accumulation in the liver is implicated in metabolic disease in an age- and sex-dependent manner. The role of hepatic lipids has been well established within the scope of metabolic insults in mice, but has been insufficiently characterized un ...

Wiley-Blackwell2017

Spike-Based Sensing and Communication for Highly Energy-Efficient Sensor Edge Nodes

Mihai Adrian Ionescu, Teodor Rosca

Highly energy-efficient wireless sensor nodes are a prerequisite for a sustainable operation of the Internet of things. Therefore, classical approaches for system design based on digital signal processing are not a viable solution, but system design has to ...

IEEE2022