Publication

Solving the mystery of the missing plasmids in seventh pandemic Vibrio cholerae strains

2022
Journal Articles

Abstract

The pathogen responsible for the continuing seventh cholera pandemic typically lacks self-replicating plasmids. Genetics, cell biology and bioinformatics analyses have identified two DNA-defence systems that protect bacterial populations from plasmids and bacteriophages, and that might have shaped the evolution of modern Vibrio cholerae.

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2022
Journal Articles

Abstract

Official source

Related concepts (21)

Cholera

Cholera ('kɒlərə) is an infection of the small intestine by some strains of the bacterium Vibrio cholerae. Symptoms may range from none, to mild, to severe. The classic symptom is large amounts of watery diarrhea that lasts a few days. Vomiting and muscle cramps may also occur. Diarrhea can be so severe that it leads within hours to severe dehydration and electrolyte imbalance. This may result in sunken eyes, cold skin, decreased skin elasticity, and wrinkling of the hands and feet. Dehydration can cause the skin to turn bluish.

Pathogen

In biology, a pathogen (πάθος, pathos "suffering", "passion" and -γενής, -genēs "producer of"), in the oldest and broadest sense, is any organism or agent that can produce disease. A pathogen may also be referred to as an infectious agent, or simply a germ. The term pathogen came into use in the 1880s. Typically, the term pathogen is used to describe an infectious microorganism or agent, such as a virus, bacterium, protozoan, prion, viroid, or fungus. Small animals, such as helminths and insects, can also cause or transmit disease.

Pathogen transmission

In medicine, public health, and biology, transmission is the passing of a pathogen causing communicable disease from an infected host individual or group to a particular individual or group, regardless of whether the other individual was previously infected. The term strictly refers to the transmission of microorganisms directly from one individual to another by one or more of the following means: airborne transmission – very small dry and wet particles that stay in the air for long periods of time allowing airborne contamination even after the departure of the host.

Related publications (2)

Solving the mystery of the missing plasmids in seventh pandemic Vibrio cholerae strains

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Rate of osmotic pressure change in drying saliva microdroplets drives inactivation of surrogate respiratory bacteria

Diverse phage defence systems define West African South American pandemic Vibrio cholerae