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Integrated Nanophotonic Biosensors for Point-of Care Diagnostics and Bioanalytical Applications

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Gram-type differentiation of bacteria with 2D hollow photonic crystal cavities

Romuald Houdré, El Hadji Malick Camara, Rita Therisod

Fast and label-free techniques to analyze viruses and bacteria are of crucial interest in biological and bio-medical applications. For this purpose, optofluidic systems based on the integration of photonic structures with microfluidic layers were shown to ...

2018

Prediction of Dispersion Rate of Airborne Nanoparticles in a Gas-Liquid Dual-Microchannel Separated by a Porous Membrane: A Numerical Study

Zohreh Sheidaei, Carlotta Guiducci

Recently, there has been increasing attention toward inhaled nanoparticles (NPs) to develop inhalation therapies for diseases associated with the pulmonary system and investigate the toxic effects of hazardous environmental particles on human lung health. ...

MDPI2022

Optofluidic nanoplasmonic biosensor for label-free live cell analysis in real time

Hatice Altug, Filiz Yesilköy, Alexander Belushkin, Xiaokang Li, Maria Soler Aznar

Cell signaling activities play a critical role in physiological and disease processes. The analysis of the tumor microenvironment or the immune system activation is nowadays providing valuable insights towards disease understanding and novel therapies deve ...

2018

Comparison of electrical and optical transduction modes of DNA-wrapped SWCNT nanosensors for the reversible detection of neurotransmitters

Jürgen Brugger, Giovanni Boero, Nergiz Sahin Solmaz

In this study, we compare the electrical and optical signal transduction of nanoscale biosensors based on single -walled carbon nanotubes (SWCNTs). Solution processable single-stranded (ss) DNA-wrapped SWCNTs were used for the fabrication of the distinct s ...

2022

Robustness Analysis of Metasurfaces: Perfect Structures Are Not Always the Best

Olivier Martin, Karim Achouri, Hsiang-Chu Wang

Optical metasurfaces rely on subwavelength scale nanostructures, which puts significant constraints on nanofabrication accuracies. These constraints are becoming increasingly important, as metasurfaces are maturing toward real applications that require the ...

AMER CHEMICAL SOC2022

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Jean-Claude Bünzli

Half a century after its initial emergence, lanthanide photonics is facing a profound remodeling induced by the upsurge of nanomaterials. Lanthanide-doped nanomaterials hold promise for bioapplications and photonic devices because they ally the unmatched a ...

WILEY-V C H VERLAG GMBH2018

Portable Memristive Biosensing System as Effective Point-of-Care Device for Cancer Diagnostics

Giovanni De Micheli, Sandro Carrara, Danilo Demarchi, Ioulia Tzouvadaki, Abuduwaili Tuoheti

Memristive biosensors have been proved as excellent candidates for ultrasensitive biosensing. In this work, a novel portable bio-detection system based on memristive biosensors is designed, developed and tested for providing a significantly fast, automatic ...

IEEE2018

Low-Loss Anisotropic Image Polaritons in van der Waals Crystal alpha-MoO3

Sergejs Boroviks

Orthorhombic molybdenum trioxide (alpha-MoO3), a newly discovered polaritonic van der Waals crystal, is attracting significant attention due to its strongly anisotropic mid-infrared phonon-polaritons. At the same time, coupling of polariton with its mirror ...

WILEY-V C H VERLAG GMBH2022

Inverse photonic design of functional elements that focus Bloch surface waves

Hans Peter Herzig, Myun Sik Kim, Babak Vosoughi Lahijani

Bloch surface waves (BSWs) are sustained at the interface of a suitably designed one-dimensional (1D) dielectric photonic crystal and an ambient material. The elements that control the propagation of BSWs are defined by a spatially structured device layer ...

Nature Publishing Group2018

Competing Adaptive Networks

Ali H. Sayed, Stefan Vlaski

Adaptive networks have the capability to pursue solutions of global stochastic optimization problems by relying only local interactions within neighborhoods. The diffusion of information through repeated interactions allows for globally optimal behavior, w ...

IEEE2021

Microfluidic platforms for high-throughput mammalian cell printing, transfection, and dosage-dependent studies

Kristina Pan Woodruff

With the advent of high-throughput and genome-wide screening initiatives, there is a need for improved methods for cell-based assays. Current approaches require expensive equipment, rely on large-scale culturing formats not suited for small or rare sample ...

EPFL2017

High Tuning Range Spiking 1R-1T VO2 Voltage-Controlled Oscillator for Integrated RF and Optical Sensing

Mihai Adrian Ionescu, Teodor Rosca, Fatemeh Qaderi Rahaqi

In this work we propose and experimentally validate a relaxation spiking oscillator architecture with ultra-high tuning range (higher than 400%, from 5KHz to more than 25kHz when the control voltage is varied from 2.5 to 5V) that exploits the reversible me ...

IEEE2021

The Molecular Mechanism of Nanodroplet Stability

Yixing Chen, Sylvie Roke, Halil Ibrahim Okur, David Mark Wilkins, Evangelia Zdrali

Mixtures of nano- and microscopic oil droplets in water have recently been rediscovered as miniature reaction vessels in microfluidic environments and are important constituents of many environmental systems, food, personal care, and medical products. The ...

Amer Chemical Soc2017

Microfluidics and cell-free synthetic biology in the development of new diagnostic and therapeutic platforms

Grégoire Michielin

In phenylketonuria, absence or malfunction of the phenylalanine hydroxylase enzyme results in toxic accumulation of phenylalanine in the body. An injectable recombinant enzyme therapy was recently approved and has the potential to improve the quality of li ...

EPFL2021

Three-dimensional fabrication of sub-micron optical waveguides in PDMS and other polymer materials

Giulia Panusa

Optical waveguides are one of the most important photonic components. They are indispensable tools in many of todayâ s technologies because of their capacity of guiding light. In particular, compact, low loss, flexible polymer optical waveguides are cruci ...

EPFL2021

Penciling a triboelectric nanogenerator on paper for autonomous power MEMS applications

Jürgen Brugger, Xiao Sheng Zhang

Triboelectric nanogenerator (TENG) has proven to be a robust power source to efficiently convert ambient mechanical energy into electricity. It experienced substantial growth in the past years owing to its appealing features that make it superior than othe ...

Elsevier Science Bv2017

Carrier-Envelope Offset-Free Pulse Train by Difference-Frequency Generation from a Si3N4-Waveguide Supercontinuum Output

Tobias Kippenberg, Miles Henry Anderson

We present a novel approach to generate a frequency comb based on Difference Frequency Generation (DFG). The frequency components required for the DFG process are generated in a Si(3)N(4)waveguide. A mode-locked 200 MHz oscillator is amplified in an Erbium ...

IEEE2020

High-throughput microfluidic platforms applied to immunoassay-based diagnostics and environmental monitoring

Francesca Volpetti

The research presented in this thesis is motivated by the aim to employ microfluidic devices for high-throughput analysis. Two applications, in particular, have been explored: diagnostics and environmental sensing. Miniaturization and multiplexing of labor ...

EPFL2017

Reconfigurable Timed Discrete-Event Systems

Matin Macktoobian

In this paper, we present the first general solution to the automatic reconfiguration problem of timed discrete-event systems. We extend the recursive forcible backtracking approach which had been already solved the automatic reconfiguration problem of unt ...

IEEE2020

Tailoring Surface Properties of Fiber Materials : Novel Opportunities in the Fabrication of Multi-scale Fiber-based Architectures

Dang Tùng Nguyen

Many surface properties of materials can be tailored by a proper physical patterning. Such patterned surfaces, commonly fabricated by wafer-based techniques, have been widely exploited for light trapping in advanced photovoltaic systems, for tailoring the ...

EPFL2017