Publication

Immunosensing by a synthetic ligand-gated ion channel

Horst Arthur Vogel, Samuel Terrettaz, Wolf-Peter Ulrich
2001
Journal Articles

Abstract

Gating of an artificial receptor was monitored for the first time by impedance spectroscopy in tethered lipid bilayer. Subnanomolar concns. of antibody were detected by modulation of the channel activity. The principle of gating by an antibody is particularly attractive because of its general character, and thus opens new possibility of immunosensing. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/547c2b9b-b03e-48a8-a36a-b17a0f10f81b

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Horst Arthur Vogel, Samuel Terrettaz, Wolf-Peter Ulrich
2001
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/547c2b9b-b03e-48a8-a36a-b17a0f10f81b

About this result

Related concepts (12)

Ion channel

Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells. Ion channels are one of the two classes of ionophoric proteins, the other being ion transporters.

Channel blocker

A channel blocker is the biological mechanism in which a particular molecule is used to prevent the opening of ion channels in order to produce a physiological response in a cell. Channel blocking is conducted by different types of molecules, such as cations, anions, amino acids, and other chemicals. These blockers act as ion channel antagonists, preventing the response that is normally provided by the opening of the channel.

Sodium channel

Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's membrane. They belong to the superfamily of cation channels. They are classified into 2 types: In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. These channels go through three different states called resting, active and inactive states.

Related publications (1)

Immunosensing by a synthetic ligand-gated ion channel

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Expression of ligand-gated ion channels with the Semliki Forest virus expression system