Rudolf HoviusExpertise
•Protein structure, expression & purification•Molecular interaction & receptor activation•Fluorescence imaging & spectroscopySignalling & sensing
Mission
=> Teaching: Lecture courses, tutorials and practicals in biochemistry, biophysical chemistry of membranes and signalling processes. Participating to the Commission d'Enseignement and Commission de l'Ecole Doctorale of Chemistry and Chemical Engineering.=> Research interests: Protein function and structure, Membrane protein (especially recepto
Emre TelatarI. Emre Telatar received the B.Sc. degree in electrical engineering from the Middle East Technical University, Ankara, Turkey, in 1986. He received the S.M. and Ph.D. degrees in electrical engineering and computer science from the Massachusetts Institute of Technology, Cambridge, in 1988 and 1992 respectively. In 1992, he joined the Communications Analysis Research Department at AT&T Bell Laboratories (later Lucent Technologies), Murray Hill, NJ. He has been at the EPFL since 2000.
Emre Telatar was the recipient of the IEEE Information Theory Society Paper Award in 2001. He was a program co-chair for the IEEE International Symposium on Information Theory in 2002, and associate editor for Shannon Theory for the IEEE Information Theory Transactions from 2001 to 2004. He was awarded the EPFL Agepoly teaching prize in 2005.
Emre Telatar's research interests are in communication and information theories.
Mihai Adrian IonescuAdrian M. Ionescu is Full Professor at the Swiss Federal Institute of Technology, Lausanne, Switzerland. He received the B.S./M.S. and Ph.D. degrees from the Polytechnic Institute of Bucharest, Romania and the National Polytechnic Institute of Grenoble, France, in 1989 and 1997, respectively. He has held staff and/or visiting positions at LETI-CEA, Grenoble, France and INP Grenoble, France and Stanford University, USA, in 1998 and 1999. Dr. Ionescu has published more than 600 articles in international journals and conferences. He received many Best Paper Awards in international conferences, the Annual Award of the Technical Section of the Romanian Academy of Sciences in 1994 and the Blondel Medal in 2009 for contributions to the progress in engineering sciences in the domain of electronics. He is the 2013 recipient of the IBM Faculty Award in Engineering. He served the IEDM and VLSI conference technical committees and was the Technical Program Committee (Co)Chair of ESSDERC in 2006 and 2013. He is a member of the SATW. He is director of the Laboratory of Micro/Nanoelectronic Devices (NANOLAB).
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Michael Christoph GastparMichael Gastpar is a (full) Professor at EPFL. From 2003 to 2011, he was a professor at the University of California at Berkeley, earning his tenure in 2008.
He received his Dipl. El.-Ing. degree from ETH Zürich, Switzerland, in 1997 and his MS degree from the University of Illinois at Urbana-Champaign, IL, USA, in 1999. He defended his doctoral thesis at EPFL on Santa Claus day, 2002. He was also a (full) Professor at Delft University of Technology, The Netherlands.
His research interests are in network information theory and related coding and signal processing techniques, with applications to sensor networks and neuroscience.
He is a Fellow of the IEEE. He is the co-recipient of the 2013 Communications Society & Information Theory Society Joint Paper Award. He was an Information Theory Society Distinguished Lecturer (2009-2011). He won an ERC Starting Grant in 2010, an Okawa Foundation Research Grant in 2008, an NSF CAREER award in 2004, and the 2002 EPFL Best Thesis Award. He has served as an Associate Editor for Shannon Theory for the IEEE Transactions on Information Theory (2008-11), and as Technical Program Committee Co-Chair for the 2010 International Symposium on Information Theory, Austin, TX.
Patrick ThiranPatrick Thiran is a full professor in network and systems theory at the School of Computer and Communication Sciences at EPFL. He holds an electrical engineering degree from the Université Catholique de Louvain, Louvain-la-Neuve, Belgium, an M.Sc. degree in electrical engineering from the University of California at Berkeley, USA, and he received the PhD degree from EPFL, in 1996. He became an adjunct professor in 1998, an assistant professor in 2002, an associate professor in 2006 and a full professor in 2011. He was with Sprint Advanced Technology Labs in Burlingame, California, in 2000-01.
His research interests are in communication and social networks, performance analysis and stochastic models. He is currently active in the analysis and design of wireless and PLC networks (scaling laws, medium access control), in network monitoring (network tomography, multi-layer networks), and data-driven network science. He also contributed to network calculus and to the theory of locally coupled neural networks and self-organizing maps.
He served as an associate editor for the IEEE Transactions on Circuits and Systems in 1997-99 and for the IEEE/ACM Transactions on Networking in 2006-10. He is currently on the editorial board of the IEEE Journal on Selected Areas in Communication. He is/was on the program committee of different conferences in networking, including ACM Sigcomm, Sigmetrics, IMC, CoNext and IEEE Infocom. He was TPC chair of AMC IMC 2011 and CoNext 2012. He is a Fellow of the Belgian American Educational Foundation and of the IEEE. He received the 1996 EPFL Doctoral Prize and the 2008 Crédit Suisse Teaching Award.
Corsin BattagliaCorsin Battaglia directs the laboratory Materials for Energy Conversion at Empa, the Swiss Federal Laboratories for Materials Science and Technology, and is Adjunct Professor of Electrical Engineering at ETH Zurich, Department of Information Technology and Electrical Engineering and Adjunct Professor of Materials Science at EPFL, School of Engineering, Institute of Materials. His research focuses on developing new materials and scalable manufacturing processes for next-generation sustainable energy storage,
Horst PickTeaching & PhD PhD Students Vivek Prakash, Yang Wang Past EPFL PhD Students as codirector Olivia Baud, Thamani Dahoun, Enio Daniel Zanchetta Courses Biotechnology lab (for CGC) ChE-433 This laboratory-training course is designed to give students a comprehensive insight into laboratory research techniques in the field of biotechnology and pharmaceutical biotechnology with practices employed in the industry. Accompanying lectures provide the theoretical background. Chemosensory receptors:
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