Autonomous and self-sustained circadian oscillators displayed in human islet cells

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In eukaryotes, RNA is synthesised in the nucleus, spliced, and exported to the cytoplasm where it is translated and finally degraded. Any of these steps could be subject to temporal regulation during the circadian cycle, resulting in daily fluctuations of ...

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Diabetes is a rapidly growing disease, with important complications that decrease the quality of life of patients. Diabetic Foot Ulceration is a major complication of diabetes and can lead to gangrene and amputation. It is related to high pressure develope ...

Obesity and type 2 diabetes are associated with cognitive dysfunction. Because the hypothalamus is implicated in energy balance control and memory disorders, we hypothesized that specific neurons in this brain region are at the interface of metabolism and ...

Neonatal and juvenile porcine islet cell clusters (ICC) present an unlimited source for islet xenotransplantation to treat type 1 diabetes patients. We isolated ICC from pancreata of 14 days old juvenile piglets and characterized their maturation by immuno ...

Ray et al. (Reports, 14 February 2020, p. 800) recently claimed temperature-compensated, free-running mRNA oscillations in Bmal1(-/-) liver slices and skin fibroblasts. We reanalyzed these data and found far fewer reproducible mRNA oscillations in this gen ...

The circadian clock regulates diurnal variations in autonomic thermoregulatory processes such as core body temperature in humans. Thus, we might expect that similar daily fluctuations also characterize human thermal perception, the ultimate role of which i ...

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Video Abstract Video Abstract: Theory of time delayed genetic oscillations with external noisy regulation We present a general theory of noisy genetic oscillators with externally regulated production rate and multiplicative noise. The observables that char ...

The circadian clock drives extensive temporal gene expression programs controlling daily changes in behavior and physiology. In mouse liver, transcription factors dynamics, chromatin modifications, and RNA Polymerase II (PolII) activity oscillate throughou ...

The mammalian liver is a central hub for systemic metabolic homeostasis. Liver tissue is spatially structured, with hepatocytes operating in repeating lobules, and sub-lobule zones performing distinct functions. The liver is also subject to extensive tempo ...

We construct reduced order models for two classes of globally coupled multi-component oscillatory systems, selected as prototype models that exhibit synchronization. These are the Kuramoto model, considered both in its original formulation and with a suita ...

Gene expression in eukaryotes is a complex multi-step process. It starts in the nucleus with transcription, the synthesis of a mRNA copy from a DNA template. While in the nucleus, the RNA transcript is subject to multiple co- and post-transcriptional modif ...

Autonomous and self-sustained circadian oscillators displayed in human islet cells

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Comprehensive analysis of the circadian nuclear and cytoplasmic transcriptome in mouse liver

Cognitive Impairment and Metabolite Profile Alterations in the Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and Sugar-Rich Diet are Normalized by Diet Reversal

Pressure Offloading Device for Diabetic Footwear Based on Magnetorheological Fluids

Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders

Multipotent mesenchymal stromal cells derived from porcine exocrine pancreas improve insulin secretion from juvenile porcine islet cell clusters

Comment on "Circadian rhythms in the absence of the clock gene Bmal1"

Human thermal perception and time of day: A review

Integrating non-visual effects of light in the automated daylight-responsive control of blinds and electric lighting

Theory of time delayed genetic oscillations with external noisy regulation

Oscillating and stable genome topologies underlie hepatic physiological rhythms during the circadian cycle

Space-time logic of liver gene expression at sub-lobular scale

Modeling synchronization in globally coupled oscillatory systems using model order reduction

Circadian dynamics of RNA localisation in the mammalian liver