Directed Evolution of Bicyclic Peptides for Therapeutic Application

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The success of phage display, used for developing target-specific binders based on peptides and proteins, depends on the size and diversity of the library screened, but generating large libraries of phage-encoded polypeptides remains challenging. New pepti ...

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The disulfide bonds that form between two cysteine residues are important in defining and rigidifying the structures of proteins and peptides. In polypeptides containing multiple cysteine residues, disulfide isomerization can lead to multiple products with ...

Directed Evolution of Bicyclic Peptides for Therapeutic Application

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Generation of a Large Peptide Phage Display Library by Self-Ligation of Whole-Plasmid PCR Product

De novo development of proteolytically resistant therapeutic peptides for oral administration

Protein Structural Information and Evolutionary Landscape by In Vitro Evolution

Generation of chiral asymmetry via helical magnetic fields

Microstructural simulation and measurement of elastic modulus evolution of hydrating cement pastes

Development of Tissue Kallikrein Inhibitors for the Treatment of Netherton Syndrome

Sexual conflict drives male manipulation of female postmating responses in Drosophila melanogaster

Linking a mutation to survival in wild mice

Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides