Publication

A Short and Convenient Synthesis of 1-Deoxymannojirimycin (DMJ) and N-oxy-Analogues from D-Fructose

Pierre Vogel, Sandrine Gerber
2009
Journal Articles

Abstract

The ketonitrone 8 was prepared from D-fructose as an inexpensive starting material, and was used in a stereoselective synthesis of 1-deoxymannojirimycin (4), its previously unknown N-hydroxy analogue 15, as well as the polyhydroxylated ketonitrone 14. The latter were assayed as potential glycosidase inhibitors on a panel of 13 selected purified enzymes. N-Hydroxy DMJ (15) exhibited a moderate and non selective activity towards the snail - mannosidase EC 3.2.1.25.

Official source

https://infoscience.epfl.ch/entities/publication/4786b2ad-7064-431f-8b23-419b82a9ec50

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A Short and Convenient Synthesis of 1-Deoxymannojirimycin (DMJ) and N-oxy-Analogues from D-Fructose

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