Publications related to A Short and Convenient Synthesis of 1-Deoxymannojirimycin (DMJ) and N-oxy-Analogues from D-Fructose

Related publications (17)

Chemodivergent Asymmetric Synthesis via Catalytically Formed Chiral Auxiliary

In summary, the development of the catalytically formed chiral auxiliary concept is described. In this approach, an oxazolidine auxiliary is installed via enantioselective Pd catalysis from readily available starting materials in an enantioselective tether ...

EPFL2023

Manganese Transfer Hydrogenases Based on the Biotin-Streptavidin Technology

Xile Hu, Florence Pojer, Kelvin Ka Ching Lau, Weijin Wang

Artificial (transfer) hydrogenases have been developed for organic synthesis, but they rely on precious metals. Native hydrogenases use Earth-abundant metals, but these cannot be applied for organic synthesis due, in part, to their substrate specificity. H ...

Wiley-VCH Verlag GmbH2023

Novel organometallic ruthenium complexes for selective activation in tumour cells

Anna Katherine Renfrew

In recent years, ruthenium-based antitumour drugs have emerged as an attractive alternative to cisplatin, exhibiting both excellent activity in tumours where cisplatin is of limited use and low general toxicity, leading to reduced side effects. Two rutheni ...

EPFL2010

Dissymmetrical Double-Chain Elongation Approach to the Asymmetric Synthesis of Long-Chain Polypropionates

Claudia Jana Exner

Polyketides show interesting biological activities and therefore represent an important class of natural products. The necessity of their diastereo- and enantioselective synthesis led to the development of numerous methodologies. A brief overview of this t ...

EPFL2010

Synthesis of novel pyrrolidine 3,4-diol derivatives as inhibitors of alpha-L-fucosidases

Pierre Vogel

The stereoselective synthesis of new 3,4-dihydroxypyrrolidine derivatives starting from D-mannose, D-ribose and L-fucose is presented. Two synthetic strategies employing organometallic addition to hemiacetalic sugars followed by selective nucleophilic disp ...

2009

Natural Product Synthesis Enabled by Domino Processes Incorporating a 1,2-Rearrangement Step

Jieping Zhu, Qian Wang, Bastien Delayre

The art of natural product total synthesis is closely associated with two major determinants: the development/application of novel chemical reactions and the innovation in strategic use of classic organic reactions. While purposely seeking/applying a new s ...

2021

Synthesis of the C(1)-C(11) polyene fragment of apoptolidin with a new sulfur dioxide-based organic chemistry

Pierre Vogel, Laure Bouchez

A new sulfur dioxide-based organic chemistry has been developed as a novel approach for the stereoselective synthesis of polyene fragments based on our one-pot, four-component synthesis of polyfunctional alpha-alkanesulfonyl-gamma,delta-unsaturated ketones ...

2005

CO2 chemical transformations using metal-organic frameworks

Serhii Shyshkanov

During the last decades, intensive efforts have been applied to tackle the enormous emissions of CO2 into atmosphere. These efforts include not only developing efficient carbon capture techniques, but also the introduction of new ways to transform the capt ...

EPFL2020

Chiral N-Heterocyclic Carbene Ligands for Asymmetric Catalysis

Johannes Diesel

N-Heterocyclic carbenes (NHCs) are the ligands of choice in a large variety of transformations entailing different transition metals. However, the number of chiral NHCs suitable as stereocontrolling ligands in asymmetric catalysis remains limited. In parti ...

EPFL2019

New composites for extraction of metal or contaminating chemical species

Wendy Lee Queen, Daniel Teav Sun

he present invention relates to a composite for extracting one or more metal or contaminating chemical species from an aerial or aqueous medium by selective binding, said composite comprising at least one porous template functionalized by at least one poly ...

2019

Catalyst design for the transformation of CO2 into value-added products

Felix Daniel Bobbink

The mass-utilization of fossil resources has led to a dramatic increase in carbon dioxide (CO2) production, most of which is released directly into the Earth's atmosphere, resulting in global warming. Efforts to contain CO2 emissions and to capture, store ...

EPFL2018

Selective Targeting of SH2 Domain–Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies

Oliver Hantschel, Florence Pojer, Tim Kükenshöner, Nadine Eliane Schmit

The binding of Src-homology 2 (SH2) domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the eight Src family kinases (SFKs). The high sequence conservation of the 120 human SH2 domains poses a significant c ...

Elsevier2017

Total Syntheses of (−)-Mersicarpine, (−)-Scholarisine G, (+)-Melodinine E, (−)-Leuconoxine, (−)-Leuconolam, (−)-Leuconodine A, (+)-Leuconodine F, and (−)-Leuconodine C: Self-Induced Diastereomeric Anisochronism (SIDA) Phenomenon for Scholarisine G and Leuconodines A and C

Jieping Zhu, Qian Wang, Zhengren Xu

Enantioselective total syntheses of title natural products from a common cyclohexenone derivative (S)-18 were reported. Ozonolysis of (S)-18 afforded a stable diketo ester (R)-17 that was subsequently converted to two skeletally different natural products, ...

Amer Chemical Soc2015

Identification of Soft Matter Binding Peptide Ligands Using Phage Display

Harm-Anton Klok

Phage display is a powerful tool for the selection of highly affine, short peptide ligands. While originally primarily used for the identification of ligands to proteins, the scope of this technique has significantly expanded over the past two decades. Pha ...

Amer Chemical Soc2015

Catalyst Development for Selective Hydrogenation of Functionalized Alkynes and Nitroarenes

Artur Elterovich Yarulin

Catalyst design is of major importance for fine chemicals industry due to complexity of the synthesis and high product quality requirements. Moreover, the catalyst formulation has to comply with the standards of health, safety and environmental regulati ...

EPFL2014

PRACTICAL SYNTHESIS OF N-ARYL-o-HYDROXYARYL KETIMINES

Qian Wang

Heating o-hydroxyacetophenones and anilines under solvent-free conditions afforded the corresponding aryl ketimines in good to excellent yields. ...

2012

Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125

Hilal Lashuel, Michel Prudent, Bruno Claude Daniel Fauvet, Mirva Hejjaoui, Filip Vercruysse

Despite increasing evidence that supports the role of different post-translational modifications (PTMs) in modulating α-synuclein (α-syn) aggregation and toxicity, relatively little is known about the functional consequences of each modification and whethe ...

2012