Publications related to Development of Selective FXIa Inhibitors Based on Cyclic Peptides and Their Application for Safe Anticoagulation

Related publications (24)

SaliencyMix plus : Noise-Minimized Image Mixing Method With Saliency Map in Data Augmentation

Data augmentation is vital in deep learning for enhancing model robustness by artificially expanding training datasets. However, advanced methods like CutMix blend images and assign labels based on pixel ratios, often introducing label noise by neglecting ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2025

Generation of LOD4 models for buildings towards the automated 3D modeling of BIMs and digital twins

Katrin Beyer, Frédéric Kaplan, Bryan German Pantoja Rosero, Alexander Michael Rusnak

An image-based methodology is presented for the automatic generation of geometric building models at LOD4, incorporating both interior and exterior geometrical information. Existing approaches often focus on simplified geometries for either exteriors or in ...

Elsevier BV2024

Tandem catalysis enables chlorine-containing waste as chlorination reagents

Paul Joseph Dyson, Xinbang Wu, Mingyang Liu

Chlorinated compounds are ubiquitous. However, accumulation of chlorine-containing waste has a negative impact on human health and the environment due to the inapplicability of common disposal methods, such as landfill and incineration. Here we report a su ...

Nature Portfolio2024

Horner-Wadsworth-Emmons olefination for bioconjugation

Yimon Aye

Through site-specific generation of intermediary reactive aldehydes, Horner-Wadsworth-Emmons olefination can now deliver selective functionalization of stable recombinant proteins and monoclonal antibodies, whilst preserving protein integrity. ...

Springernature2024

Multilingual Contrastive Decoding via Language-Agnostic Layers Skipping

Chris Wendler

Decoding by contrasting layers (DoLa), is designed to improve the generation quality of large language models (LLMs) by contrasting the prediction probabilities between an early exit output (amateur logits) and the final output (expert logits).However, we ...

Association for Computational Linguistics (ACL)2024

A heterogeneously integrated lithium niobate-on-silicon nitride photonic platform

Tobias Kippenberg, Junqiu Liu, Rui Ning Wang, Johann Emmeram Riemensberger, Anat Siddharth, Mikhail Churaev, Miles Henry Anderson, Viacheslav Snigirev, Terence Albert Emile Blésin

The availability of thin-film lithiumniobate on insulator (LNOI) and advances in processing have led to the emergence of fully integrated LiNbO3 electro-optic devices. Yet to date, LiNbO3 photonic integrated circuits have mostly been fabricated using non-s ...

Nature Portfolio2023

Evaluation of genetic demultiplexing of single-cell sequencing data from model species

Clement Helsens

Single-cell sequencing (sc-seq) provides a species agnostic tool to study cellular processes. However, these technologies are expensive and require sufficient cell quantities and biological replicates to avoid artifactual results. An option to address thes ...

LIFE SCIENCE ALLIANCE LLC2023

Size dependence of second-harmonic scattering from nanoparticles: Disentangling surface and electrostatic contributions

Sylvie Roke, Arianna Marchioro, Bingxin Chu

Polarimetric angle-resolved second-harmonic scattering (AR-SHS) is an all-optical tool enabling the study of unlabeled interfaces of nano-sized particles in an aqueous solution. As the second harmonic signal is modulated by interference between nonlinear c ...

AIP Publishing2023

A MOF-Based Spatial-Separation Layer to Enable a Uniform Favorable Microenvironment for Electrochemical CO2 Reduction

Jian Li

Regulating the local microenvironment of active sites to increase their specific CO2 concentration and pH gradient, is a promising approach to optimize the electrochemical CO2 reduction reaction (eCO(2)RR). However, currently reported morphological strateg ...

2023

Techno-economic analysis of solar hydrogen production via PV power/concentrated solar heat driven solid oxide electrolysis with electrical/thermal energy storage

Jan Van Herle

Green hydrogen production via electrochemical water splitting is a promising approach for future sustainable energy and industry. Among the existing water electrolysis technologies, solid oxide steam electrolysis exhibits the highest electrical efficiency, ...

ELSEVIER2023

Optimal sizing and siting of energy storage systems considering curtailable photovoltaic generation in power distribution networks

Fabrizio Sossan, Rahul Kumar Gupta

This work proposes a method for optimal planning (sizing and siting) energy storage systems (ESSs) in power distribution grids while considering the option of curtailing photo-voltaic (PV) generation. More specifically, for a given PV generation capacity t ...

2023

Template directed synthesis of antibody Fc conjugates with concomitant ligand release

Natalia Gasilova

Antibodies are an attractive therapeutic modality for cancer treatment as they allow the increase of the treatment response rate and avoid the severe side effects of chemotherapy. Notwithstanding the strong benefit of antibodies, the efficacy of anti-cance ...

ROYAL SOC CHEMISTRY2022

The New Brutalism, invenzione di uno stile

Silvia Groaz

The concept of New Brutalism has been the victim of a series of misunderstandings, myths and aporias. The initial intentions, devoid of any principle or dogma, have passed from hand to hand. The original definitionâ if only one can be identifiedâ has be ...

EPFL2021

Overcapacity in European power systems: Analysis and robust optimization approach

Michel Bierlaire, François Maréchal, Frédéric Louis François Babonneau, Stefano Moret

The planning of national power systems is traditionally based on long-term forecasts of electricity demand and fuel prices. However, over such long time horizons (20-50 years), these forecasts often prove to be inaccurate. As an example, wrong projections ...

ELSEVIER SCI LTD2020

Sulfonated Nanomaterials with Broad-Spectrum Antiviral Activity Extending beyond Heparan Sulfate-Dependent Viruses

Francesco Stellacci, Matteo Gasbarri, Valeria Cagno

Viral infections are among the main causes of death worldwide, and we lack antivirals for the majority of viruses. Heparin-like sulfated or sulfonated compounds have been known for decades for their ability to prevent infection by heparan sulfate proteogly ...

AMER SOC MICROBIOLOGY2020

Characterization of the Mercapturic Acid Pathway, an Important Phase II Biotransformation Route, in a Zebrafish Embryo Cell Line

Kristin Schirmer, Alena Tierbach

In view of the steadily increasing number of chemical compounds used in various products and applications, high-throughput toxicity screening techniques can help meeting the needs of 21st century risk assessment. Zebrafish (Danio rerio), especially its ear ...

AMER CHEMICAL SOC2020

Development of cyclic peptide inhibitors of coagulation factor XIa for safer anticoagulation

Vanessa Carle

Hemostasis is a complex physiological process responsible for the prevention of blood loss caused by vascular injury. The dysregulation of this delicate mechanism can lead to thromboembolic diseases, the leading cause of death worldwide. Anticoagulants are ...

EPFL2019

Online Gait Transitions and Disturbance Recovery for Legged Robots via the Feasible Impulse Set

Auke Ijspeert

Gaits in legged robots are often hand tuned and time based, either explicitly or through an internal clock, for instance, in the form of central pattern generators. This strategy requires trial and error to identify leg timings, which may not be suitable i ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2019

Ultra-low noise microwave signal generation with an optical frequency comb

Romain Dany Bruno Bouchand

Photonic synthesis of radio frequency waveforms revived the quest for unrivalled microwave purity by its seducing ability to convey the benefits of the optics to the microwave world. In this contribution, we will present a high-fidelity transfer of frequen ...

SPIE-INT SOC OPTICAL ENGINEERING2018

Single Live Cell Monitoring of Protein Turnover Reveals Intercellular Variability and Cell-Cycle Dependence of Degradation Rates

Felix Naef, David Michael Suter, Eric Paquet, Andrea Brigitta Alber

Cells need to reliably control their proteome composition to maintain homeostasis and regulate growth. How protein synthesis and degradation interplay to control protein expression levels remains unclear. Here, we combined a tandem fluorescent timer and pu ...

CELL PRESS2018