Publications related to Molecular Basis of CLC Antiporter Inhibition by Fluoride

Related publications (28)

Structural heterogeneity of the ion and lipid channel TMEM16F

Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which functions as an ion channel and a phospholipid scramblase. Despite the availability of several TMEM16F cryogenic electron microscopy (cryo-EM) structures, the mechanism of activation ...

Nature Portfolio2024

Antibody-peptide conjugates for targeted inhibition of cysteine proteases

Elisa Oricchio

We developed a rational approach to design peptide-based covalent inhibitors and coupled the inhibitors with antibodies for cell-specific delivery. We used this platform to generate antibody-peptide inhibitor conjugates (APICs) that target a family of prot ...

Nature Portfolio2024

A multichannel versatile brain activity classification and closed loop neuromodulation system, device and method using a highly multiplexed mixed-signal front-end

Mahsa Shoaran, Bingzhao Zhu, Uisub Shin

A closed-loop neuromodulation system, including an electrode array that is implantable to a brain of a subject, analog front-end device (AFD) for selectively selecting and reading a plurality of channels from electrode array, a finite impulse response (FIR ...

2023

Beam homogeneity of caesium seeded SPIDER using a direct beamlet current measurement

Basile Marie Jacques Pouradier Duteil

The ITER Heating Neutral Beam (HNB) source prototype SPIDER (Source for the Production of Ions of Deuterium Extracted from a Radio frequency plasma), hosted at the Neutral Beam Test Facility (NBTF) in Padova, Italy, has recently started operating with evap ...

ELSEVIER SCIENCE SA2023

Toward Band n78 Shear Bulk Acoustic Resonators Using Crystalline Y-Cut Lithium Niobate Films With Spurious Suppression

Luis Guillermo Villanueva Torrijo, Soumya Yandrapalli

This work presents the study of suspended Y-cut Lithium Niobate shear bulk acoustic resonators for wide band filter applications in the frequency range of 3.5-4.5GHz. The resonators consist of a Lithium Niobate film with Aluminum top interdigitated electro ...

Institute of Electrical and Electronics Engineers2023

Information Theory in Transmembrane Transport

Solange Marie Flatt

The past decades have seen the advent of information theory in various fields, from quantum physics to cosmology. At an intermediary scale between atomic and cosmological scales are biological systems and in particular the cell, as a constitutive element o ...

EPFL2023

Computational Studies of the Proton-Coupled Metal Ion Transport in the SLC11/NRAMP Family of Transporters

Maria Letizia Merlini

In the last years, it has been demonstrated a link between the overload of metal ions inside nervous system cells and the onset of severe neurodegenerative diseases. This prompted the investigation of the structural and functional properties of transporter ...

EPFL2022

Investigation of Carboxylic Acid Isosteres and Prodrugs for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme

Alexander Lund Nielsen

Sirtuin 5 (SIRT5) is a protein lysine deacylase enzyme that regulates diverse biology by hydrolyzing epsilon-N-carboxyacyllysine posttranslational modifications in the cell. Inhibition of SIRT5 has been linked to potential treatment of several cancers but ...

Wiley-VCH Verlag GmbH2022

Study of Thin Film LiNbO3 Laterally Excited Bulk Acoustic Resonators

Luis Guillermo Villanueva Torrijo, Soumya Yandrapalli, Hüseyin Baris Atakan

This work presents an in-depth study of simulation and measurement results of laterally excited shear bulk acoustic resonators (XBAR) in Lithium Niobate, at 5 GHz with high electromechanical coupling factor (k(t)(2)) as high as 25%, and with impedances at ...

Institute of Electrical and Electronics Engineers2022

Silicon photonic microelectromechanical systems add-drop ring resonator in a foundry process

Niels Quack, Alain Yuji Takabayashi, Hamed Sattari

Photonic add-drop filters are crucial components for the implementation of wavelength division multiplexing (WDM) in fiber-optic communication systems. The recent progress in photonic integration has shown the potential to integrate photonic add-drop filte ...

SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS2022

Direct observation of water-mediated single-proton transport between hBN surface defects

Aleksandra Radenovic, Ahmet Avsar, Evgenii Glushkov, Jean Camille Benjamin Comtet

Super-resolution microscopy of defects in a two-dimensional material unveils the transport of single proton charges at solid/water interfaces. Aqueous proton transport at interfaces is ubiquitous and crucial for a number of fields, ranging from cellular tr ...

2020

Simultaneous unwrapping and low pass filtering of continuous phase maps based on autoregressive phase model and wrapped Kalman filtering

Pramod Rastogi, Rishikesh Dilip Kulkarni

We propose a simultaneous noise filtering and phase unwrapping algorithm. Spatial evolution of phase is modeled as an autoregressive Gaussian Markov random field. Accordingly, phase value at a pixel is related to phase values at surrounding pixels in a pro ...

2020

Learning Temporary Block-Based Bidirectional Incongruity-Aware Correlation Filters for Efficient UAV Object Tracking

Yujie He

In the field of UAV object tracking, correlation filter based approaches have received lots of attention due to their computational efficiency. The methods learn filters by the ridge regression and generate response maps to distinguish the specified target ...

2020

Stabilization and Performance Improvement of Power-Hardware-in-the-Loop Test Using a Robust Data-Driven Method

Alireza Karimi, Seyed Sohail Madani

Power-Hardware-in-the-Loop (PHIL) setups have gained high importance in validation of the performance of newly developed instruments and devices with low risk and implementation cost. However, the interconnection of a power hardware with a simulated model ...

2022

A Subwavelength Microwave Bandpass Filter Based on a Chiral Waveguide

Romain Christophe Rémy Fleury, Maliheh Khatibi Moghaddam

Wave manipulation at a subwavelength scale has recently attracted significant interest, especially for low-frequency wave propagation, from acoustic to microwave devices. Recently, a few methods achieving subwavelength routing using locally resonant metama ...

IEEE Xplore2020

A Wideband Low-Power Cryogenic CMOS Circulator for Quantum Applications

Edoardo Charbon, Andrea Ruffino, Yatao Peng

Quantum computers require classical electronics to ensure fault-tolerant operation. To address compactness and scalability, it was proposed to implement such electronics as integrated circuits operating at cryogenic temperatures close to those at which qua ...

2020

Image-Based Marker-Free Screening of GABA(A) Agonists, Antagonists, and Modulators

Pierre Marquet, Gerardo Turcatti, Benjamin Rappaz, Pascal Jourdain, Fabien Kuttler, Damiano Banfi

The ionotropic GABA(A) receptors represent the main target for different groups of widely used drugs having hypnotic and anxiolytic effects. So far, most approaches used to assess GABA activity involve invasive low -throughput electrophysiological techniqu ...

2019

Protons and Hydroxide Ions in Aqueous Systems

Sylvie Roke

Understanding the structure and dynamics of water's constituent ions, proton and hydroxide, has been a subject of numerous experimental and theoretical studies over the last century. Besides their obvious importance in acid-base chemistry, these ions play ...

American Chemical Society2016

A 6.5-GHz Cryogenic All-Pass Filter Circulator in 40-nm CMOS for Quantum Computing Applications

Edoardo Charbon, Andrea Ruffino, Yatao Peng

Cryogenic solid-state quantum processors require classical control and readout electronics; to achieve compactness and scalability, cryogenic integrated circuits have been recently proposed for this goal. Circulators are widely used in readout circuits, ho ...

2019

Embedded Polarizing Filters to Separate Diffuse and Specular Reflection

Adam James Scholefield, Gilles Baechler, Laurent Valentin Jospin

Polarizing filters provide a powerful way to separate diffuse and specular reflection; however, traditional methods rely on several captures and require proper alignment of the filters. Recently, camera manufacturers have proposed to embed polarizing micro ...

SPRINGER INTERNATIONAL PUBLISHING AG2019