Publication

Antibody-peptide conjugates for targeted inhibition of cysteine proteases

Elisa Oricchio
2024
Journal Articles

Abstract

We developed a rational approach to design peptide-based covalent inhibitors and coupled the inhibitors with antibodies for cell-specific delivery. We used this platform to generate antibody-peptide inhibitor conjugates (APICs) that target a family of proteases, the cysteine cathepsins. Our drug design and targeted delivery approach ensure specific inhibition and achieve therapeutic efficacy in different cancer cells and osteoclasts.

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Antibody-peptide conjugates for targeted inhibition of cysteine proteases

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