Proceedings of the 2018 next-generation Gamma Knife research meeting

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Over the past decade, research has shown that the primary motor cortex (M1), the brain's main output for movement, also responds to rewards. These reward signals may shape motor output in its final stages, influencing movement invigoration and motor learni ...

Restoring the ability to walk is a priority for individuals with neurological disorders or neurotraumatic injuries, given its significant impact on independence and quality of life. Multimodal closed-loop strategies that integrate robotic assistance and ne ...

Over the last two decades, Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI) has been developed as a powerful MR imaging modality that allows estimating non-invasively the microscopic structure of biological tissues by exploiting the natural motion of ...

The space industry has experienced substantial growth in recent years, leading to rapid advancements in space exploration and space-based technologies. Consequently, the study of electronics and sensor performance in extreme environments has become crucial ...

Proprioception tells the brain the state of the body based on distributed sensory neurons. Yet, the principles that govern proprioceptive processing are poorly understood. Here, we employ a task -driven modeling approach to investigate the neural code of p ...

Neuroprostheses have been used clinically for decades, to help restore or preserve brain functions, when pharmaceutical treatments are inefficient. Although great progress in the field has been made over the years to interface with the nervous system, surf ...

Interaction with microenvironmental factors is crucial for the regulation of hematopoietic stem cell (HSC) function. Stroma derived factor (SDF)-1 alpha supports HSCs in the quiescent state and is central to the homing of transplanted HSCs. Here, we show t ...

Digital brain atlases define a hierarchy of brain regions and their locations in three-dimensional space. They provide a standard coordinate system in which diverse datasets can be integrated for visualization and analysis. They also enable building of dat ...

Modeling the interaction of ionizing radiation, either light or ions, in integrated circuits is essential for the development and optimization of optoelectronic devices and of radiation-tolerant circuits. Whereas for optical sensors photogenerated carriers ...

This dataset contains some images (TIFF image data) of brain juvenile rats Wistar Han (P14) scanned immunostained slides by using an automated slide scanner (Olympus, VS120-L100, GER) equipped with a UPLSAPO 20x/0.75 air objective (Olympus, GER) and a Pi ...

Purpose Glioblastoma (GBM) is the most aggressive malignant primary brain tumor. The unfavorable prognosis despite maximal therapy relates to high propensity for recurrence. Thus, overall survival (OS) is quite limited and local failure remains the fundame ...

In computational neuroscience, multicompartment models are among the most biophysically realistic representations of single neurons. Constructing such models usually involves the use of the patch-clamp technique to record somatic voltage signals under diff ...

Glioblastoma (GBM) is the most aggressive brain tumor type in adults. GBM is heterogeneous, with a compact core lesion surrounded by an invasive tumor front. This front is highly relevant for tumor recurrence but is generally non-detectable using standard ...

Microsurgical resection of primary brain tumors located within or near eloquent areas is challenging. Primary aim is to preserve neurological function, while maximizing the extent of resection (EOR), to optimize long-term neurooncological outcomes and qual ...

Essential tremor (ET) is a prevalent movement disorder characterized by marked clinical heterogeneity. Here, we explored the morphometric underpinnings of this cross-subject variability on a cohort of 34 patients with right -dominant drug-resistant ET and ...

The neutron time-of-flight (n_TOF) facility at the European Laboratory for Particle Physics (CERN) is a pulsed white-spectrum neutron spallation source producing neutrons for two experimental areas: the Experimental Area 1 (EAR1), located 185 m horizontall ...

The present manuscript documents the development of a practical calculation scheme to model the response of a diamond detector in the mixed (neutron and gamma) radiation field of the CROCUS experimental reactor at EPFL. The model is shown to perform reason ...

One challenge in designing RF wireless bioelectronic devices is the impact of the interaction between electromagnetic waves and host body tissues on far-field wireless performance. In this paper, we investigate a peculiar phenomenon of implantable RF wirel ...

H3K27M-mutant diffuse midline glioma (DMG) patients have no proven effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the mechanism behind this remains unknown. We assessed clinical outcomes, tumor sequencing, and tissue/ ...

The output obtained from operando X-ray diffraction experiments on Ti-6Al-4V is used to verify the accuracy of four FEM models in predicting the temperature evolution of the solidified domain, the cooling rates of the alpha and beta phases, and the influen ...

Proceedings of the 2018 next-generation Gamma Knife research meeting

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Reward signals in the motor cortex: from biology to neurotechnology

Multimodal closed-loop strategies for gait recovery after spinal cord injury and stroke via the integration of robotics and neuromodulation

Simulation-based Microstructure Imaging: Towards Realistic White Matter Modeling using Monte Carlo Methods in DW-MRI

Single-Photon Avalanche Diode Image Sensors for Harsh Radiation Environments

Task-driven neural network models predict neural dynamics of proprioception

Unraveling behavior and cortical signals to guide the development of soft neuroprostheses for auditory restoration and spreading depolarization

Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function

Enhancement of brain atlases with region-specific coordinate systems: flatmaps and barrel column annotations

A novel approach for SPICE modeling of light and radiation effects in ICs

Nissl_4, Raw images for Machine learning for histological annotation and quantification of cortical layers

Standardized intraoperative 5-ALA photodynamic therapy for newly diagnosed glioblastoma patients: a preliminary analysis of the INDYGO clinical trial

A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays

Hyperpolarized C-13-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma

Impact of combined use of intraoperative MRI and awake microsurgical resection on patients with gliomas: a systematic review and meta-analysis

Exploring the heterogeneous morphometric data in essential tremor with probabilistic modelling

Design of the third-generation lead-based neutron spallation target for the neutron time-of-flight facility at CERN

Modeling the response of a diamond detector in the zero power reactor CROCUS

Radiation Patterns of RF Wireless Devices Implanted in Small Animals: Unexpected Deformations Due to Body Resonance

Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways

Verification of selective laser melting heat source models with operando X-ray diffraction data