Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism

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We developed a rational approach to design peptide-based covalent inhibitors and coupled the inhibitors with antibodies for cell-specific delivery. We used this platform to generate antibody-peptide inhibitor conjugates (APICs) that target a family of prot ...

Cysteine cathepsins are a family of proteases that are relevant therapeutic targets for the treatment of different cancers and other diseases. However, no clinically approved drugs for these proteins exist, as their systemic inhibition can induce deleterio ...

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ABCG2 is an ATP-binding cassette transporter that exports a wide range of xenobiotic compounds and has been recognized as a contributing factor for multidrug resistance in cancer cells. Substrate and inhibitor interactions with ABCG2 have been extensively ...

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A series of Ga(Q(n))(3) coordination compounds have been synthesized, where HQ(n) is 1-phenyl-3-methyl-4-RC(=O)-pyrazolo-5-one. The complexes have been characterized through analytical data, NMR and IR spectroscopy, ESI mass spectrometry, elemental analysi ...

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Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism

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Development of cysteine cathepsin inhibitors combined with cell type-specific delivery for the treatment of B-cell lymphoma and solid tumors

Antibody-peptide conjugates for targeted inhibition of cysteine proteases

Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins

A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation

Ru(II)-Arene Complexes of Curcumin and Bisdesmethoxycurcumin Metabolites

From Sequence to Dynamics to Function: Computational Design of Allostery and Ligand Selectivity in G-Protein Coupled Receptors

Slow-Binding and Covalent HDAC Inhibition: A New Paradigm?

Exploration and modulation of mechanical cues for enhanced cancer immunotherapy

Investigating the intra-molecular and inter-molecular effects of post-translational modifications on intrinsically disordered protein regions and structured protein regions

Towards improving full-length ribosome density prediction by bridging sequence and graph-based representations

Predicting protein interactions using geometric deep learning on protein surfaces

Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies

Combination of dielectrophoretic and hydrodynamic traps for the controlled contact between cells or beads and application to adhesion assays

Metabolic dependencies of metastasis-initiating cells in breast cancer

Mechanical Properties and Nanomotion of BT-20 and ZR-75 Breast Cancer Cells Studied by Atomic Force Microscopy and Optical Nanomotion Detection Method

Multitarget-Directed Gallium(III) Tris(acyl-pyrazolonate) Complexes Induce Ferroptosis in Cancer Cells via Dysregulation of Cell Redox Homeostasis and Inhibition of the Mevalonate Pathway

A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers

KRAB zinc finger proteins link heterochromatin maintenance to replicative stress and inflammation in diffuse large B-cell lymphoma

Optimised three-dimensional in vitro retinoblastoma models tailored for drug discovery and clinical translatability

Cancer hallmarks intersect with neuroscience in the tumor microenvironment