Improving the binding affinity of in-vitro-evolved cyclic peptides by inserting atoms into the macrocycle backbone

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The sensitivity of enteroviruses to disinfectants varies among genetically similar variants and coincides with amino acid changes in capsid proteins, although the effect of individual substitutions remains unknown. Here, we employed reverse genetics to inv ...

In this thesis, we conduct a comprehensive investigation into structural instabilities of both elastic and magneto-elastic beams and shells, resulting in a creative proposal to design a programmable braille reader. Methodologically, we combine numerical si ...

Macrocycles provide an attractive modality for drug development but the identification of ligands to targets of interest is hindered by the lack of large macrocyclic compound libraries for high-throughput screening. A strategy to efficiently synthesize lar ...

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Macrocycles offer an attractive format for drug development due to their good binding properties and potential to cross cell membranes. To efficiently identify macrocyclic ligands for new targets, methods for the synthesis and screening of large combinator ...

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Improving the binding affinity of in-vitro-evolved cyclic peptides by inserting atoms into the macrocycle backbone

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Influence of Amino Acid Substitutions in Capsid Proteins of Coxsackievirus B5 on Free Chlorine and Thermal Inactivation

Instabilities in Elastic and Magneto-Elastic Beams and Shells: from Shell Buckling to the Design of a Programmable Braille Reader

Methods for high-throughput synthesis and screening of peptide libraries

Short-term behavior of glass fiber-polymer composite bending-active elastica beam under service load application

Influence of model uncertainty and long term deformations in action effects calculation in reinforced concrete structures

A global framework for data-informed bridge examination

Interrupted Polonovski Strategy for the Synthesis of Functionalized Amino Acids and Peptides

Experimental Investigation on Size-Effect of Rubble Stone Masonry Walls Under In-Plane Horizontal Loading: Overview and Preliminary Results

Development of tools and methods for protein identification: From single molecules to in vivo applications

Fluorescent fatty acid conjugates for live cell imaging of peroxisomes

FLO:RE – A new floor system made of reused reinforced concrete and steel elements

Influence of fiber orientation on the tensile behavior of UHPFRC and reinforced UHPFRC under static and fatigue loadings

Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation

Investigating the intra-molecular and inter-molecular effects of post-translational modifications on intrinsically disordered protein regions and structured protein regions

Solid-phase peptide synthesis in 384-well plates

Hypervalent Iodine: New Reagents and Functionalization of Peptides

Synthesis and application of bifunctional hypervalent iodine reagents for peptide modification

Single-Molecule Peptide Identification Using Fluorescence Blinking Fingerprints

Computational Studies for the Design of Metalloenzyme Mimics

De novo designed proteins: a study in engineering novel folds and functions