Publication

Interrupted Polonovski Strategy for the Synthesis of Functionalized Amino Acids and Peptides

Jérôme Waser, Christine Alice Jacqueline Marty
2024
Journal Articles

Abstract

The alpha-functionalization of carbamate-protected hydroxylamine glycine derivatives, acting as imine surrogates via an interrupted Polonovski reaction, is described to access functionalized amino acid derivatives. The addition of C, N, O, and S nucleophiles was achieved in a one-pot procedure in 37% to 92% yield. This method could be extended to dipeptide derivatives for the functionalization of both the C-terminus and N-terminus.

Official source

https://infoscience.epfl.ch/entities/publication/a0eae2db-ca66-4f51-ac71-e22793070203

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Interrupted Polonovski Strategy for the Synthesis of Functionalized Amino Acids and Peptides

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