The finger subdomain of yeast telomerase cooperates with Pif1p to limit telomere elongation

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Telomeres-repeated, noncoding nucleotide motifs and associated proteins that are found at the ends of eukaryotic chromosomes-mediate genome stability and determine cellular lifespan1. Telomeric-repeat-containing RNA (TERRA) is a class of long noncoding RNA ...

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Telomerase negative cancer cell types use the Alternative Lengthening of Telomeres (ALT) pathway to elongate telomeres ends. Here, we show that silencing human DNA polymerase (Pol λ) in ALT cells represses ALT activity and induces telomeric stress. In addi ...

Phase separation concentrates mitochondrial RNA granules. Here Rey et al., show that mitochondrial RNA granules (MRGs) behaviour is consistent with liquid-liquid phase separation (LLPS) and their fusion coincides with mitochondrial remodelling. Mitochondri ...

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Telomeres protect chromosome ends from nucleolytic degradation, uncontrolled recombination by DNA repair enzymes and checkpoint signaling, and they provide mechanisms for their maintenance by semiconservative DNA replication, telomerase and homologous reco ...

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The finger subdomain of yeast telomerase cooperates with Pif1p to limit telomere elongation

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Challenging endings: How telomeres prevent fragility

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RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops

Dynamics of the most common pathogenic mtDNA variant m.3243A > G demonstrate frequency-dependency in blood and positive selection in the germline

Robust landscapes of ribosome dwell times and aminoacyl-tRNAs in response to nutrient stress in liver

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Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics

The human telomeric proteome during telomere replication

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The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and periphery

The ETFL formulation allows multi-omics integration in thermodynamics-compliant metabolism and expression models

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Circadian dynamics of RNA localisation in the mammalian liver

Requirements for DNA bubble structure for efficient cleavage by helix-two-turn-helix DNA glycosylases

The role and transcriptional regulation of FAM46A in adipocyte differentiation