Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies

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ZNF93 is a primate-restricted Krüppel-associated box zinc finger protein responsible for repressing 20- to 12-My-old L1 transposable elements. Here, we reveal that ZNF93 also regulates the key cancer driver APOBEC3B—a mutagenic enzyme linked to tumorigenes ...

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The phenomenon of allostery, a general property in proteins that has been heralded as "the second secret of life" remains elusive to our understanding and even more challenging to incorporate into protein design. One example of allosteric proteins with gre ...

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Cysteine cathepsins are a family of proteases that are relevant therapeutic targets for the treatment of different cancers and other diseases. However, no clinically approved drugs for these proteins exist, as their systemic inhibition can induce deleterio ...

Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies

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Abstract 4588: Cell states and resistance in colorectal cancer: What can we learn from patient-derived organoids?

Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B

Nanomotion-Based Drug Sensitivity Prediction in Ovarian and Colon Cancer Cell Lines Using Machine Learning

Functional dynamics of G protein-coupled receptors reveal new routes for drug discovery

Breaking the Rhythm: Harnessing the Menstrual Cycle for Better Chemotherapy

A new effLuc/Kate dual reporter allele for tumor imaging in mice

Nongenetic evolution of the tumor: from challenges to new therapeutic opportunities

Development of cysteine cathepsin inhibitors combined with cell type-specific delivery for the treatment of B-cell lymphoma and solid tumors

Antibody-peptide conjugates for targeted inhibition of cysteine proteases

A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation

Microsecond Time-Resolved Cryo-Electron Microscopy

Convergent inducers and effectors of T cell paralysis in the tumour microenvironment

Ru(II)-Arene Complexes of Curcumin and Bisdesmethoxycurcumin Metabolites

SGDA: Towards 3-D Universal Pulmonary Nodule Detection via Slice Grouped Domain Attention

Exploration and modulation of mechanical cues for enhanced cancer immunotherapy

From Sequence to Dynamics to Function: Computational Design of Allostery and Ligand Selectivity in G-Protein Coupled Receptors

NMR-based metabolomics combined with metabolic pathway analysis reveals metabolic heterogeneity of colorectal cancer tissue at different anatomical locations and stages

The role of LRRK2 in lung adenocarcinoma

Slow-Binding and Covalent HDAC Inhibition: A New Paradigm?

Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins