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Mahmut Selman Sakar

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Publications associées (47)

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Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation

Mahmut Selman Sakar, Andrew Charles Oates, Erik Mailand, Ece Özelçi, Matthias Rüegg

Classic microsurgical techniques, such as those used in the early 1900s by Mangold and Spemann, have been instrumental in advancing our understanding of embryonic development. However, these techniques are highly specialized, leading to issues of inter-ope ...

Nature Research2022

A graduate laboratory experiment to study the dynamics of an acoustically levitated particle

Bora Yalcin, Mahmut Selman Sakar, Amit Yedidia Dolev, Lorenzo Francesco John Noseda

The comprehension of physical wave phenomena is imperative for students in the fields of engineering and basic sciences. Laboratory experiments that involve generation of acoustic waves can be used to explain advanced nonlinear wave phenomena. Acoustic lev ...

2023

Locomotion of Sensor‐Integrated Soft Robotic Devices Inside Sub‐Millimeter Arteries with Impaired Flow Conditions

Diego Ghezzi, Mahmut Selman Sakar, Amit Yedidia Dolev, Lucio Feo Pancaldi-Giubbini, Adele Fanelli, Lorenzo Francesco John Noseda

One of the grand challenges in interventional cardiology and neuroradiology is to minimize the operation time and risk of damage during catheterization. These two factors drastically increase if the target location resides in small and tortuous vessels. Fl ...

Wiley2022

Ultraflexible flow directed device and system

Mahmut Selman Sakar, Lucio Feo Pancaldi-Giubbini, Pietro Luciano Jakobus Dirix

A flow directed device adapted to be guided by a fuid, such as blood, flow within a tubular structure such as a blood vessel is disclosed, said device comprising a proximal end (100), a distal end (101) and an elongated body (102) in between defining a lon ...

2021

Dynamics of entrapped microbubbles with multiple openings

Mahmut Selman Sakar, Murat Kaynak, Amit Yedidia Dolev

Microbubbles excited by acoustic fields inside water oscillate, and generate acoustic radiation forces and drag-induced acoustic streaming. These forces can be harnessed in various biomedical applications such as targeted drug delivery and on-chip biomanip ...

2022

Compound micromachines powered by acoustic streaming

Mahmut Selman Sakar, Murat Kaynak, Furkan Ayhan

This paper presents the design, fabrication, and operation of compound micromachines powered by acoustic streaming. The machine components were directly incorporated around pillars serving as shafts without further assembly steps using a single-step in sit ...

IEEE2019

Pulsatile Flow-Induced Fatigue-Resistant Photopolymerizable Hydrogels for the Treatment of Intracranial Aneurysms

Dominique Pioletti, Christophe Moser, Mahmut Selman Sakar, Andreas Schmocker, Lucio Feo Pancaldi-Giubbini, Oriane Poupart

An alternative intracranial aneurysm embolic agent is emerging in the form of hydrogels due to their ability to be injected in liquid phase and solidify in situ. Hydrogels have the ability to fill an aneurysm sac more completely compared to solid implants ...

2021

An acoustic levitation platform for high-content histological analysis of 3D tissue culture

Mahmut Selman Sakar, Emilie Vuille-Dit-Bille

Miniaturized three-dimensional (3D) cell culture systems, in particular organoids and spheroids, hold great potential for studying morphogenesis, disease modeling, and drug discovery. However, sub-cellular resolution 3D imaging of these biological samples ...

Royal Society of Chemistry (RSC)2025

A Robotic Surgery Platform for Automated Tissue Micromanipulation in Zebrafish Embryos

Mahmut Selman Sakar, Andrew Charles Oates, Ece Özelçi, Laurel Ann Rohde

Microsurgical manipulations are key experimental techniques in life science research, particularly in embryology. These techniques are most often performed manually by highly skilled scientists, posing limitations on speed, precision, and reproducibility. ...

2024

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

Beat Fierz, Mahmut Selman Sakar, Andrea Ablasser, Murat Kaynak, Kristina Makasheva, Alexiane Clara Decout, Baptiste Claude André Guey, Marilena Wischnewski

The appearance of DNA in the cytosol is perceived as a danger signal that stimulates potent immune responses through cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS). How cells regulate the activity of cGAS toward self-DNA and guard a ...

American Association for the Advancement of Science2020

Surface and bulk stresses drive morphological changes in fibrous microtissues

Mahmut Selman Sakar, Erik Mailand, Nikolaos Bouklas

Engineered fibrous tissues consisting of cells encapsulated within collagen gels are widely used three-dimensional (3D) in vitro models of morphogenesis and wound healing. While cell-mediated matrix remodeling that occurs within these scaffolds has been ex ...

2019

Investigating Tissue Mechanics in vitro Using Untethered Soft Robotic Microdevices

Mahmut Selman Sakar, Ece Özelçi, Raquel Filipa Penacho Parreira

This paper presents the design, fabrication, and operation of a soft robotic compression device that is remotely powered by laser illumination. We combined the rapid and wireless response of hybrid nanomaterials with state-of-the-art microengineering techn ...

2021

A model for 3D deformation and reconstruction of contractile microtissues

Mahmut Selman Sakar, Jaemin Kim, Erik Mailand, Nikolaos Bouklas

Tissue morphogenesis and regeneration are essentially mechanical processes that involve coordination of cellular forces, production and structural remodeling of extracellular matrix (ECM), and cell migration. Discovering the principles of cell–ECM interact ...

2020

Magnetic microrobots with addressable shape control

Mahmut Selman Sakar

Shape shifting soft microrobots are generated from self-folding hydrogel bilayer structures. The folding conditions are analyzed to develop an optimal strategy for producing desired three-dimensional shapes. We present two different methods for programming ...

IEEE2016

Precise tactile stimulation of worker ants by a robotic manipulator reveals that individual responses are density‐ and context‐dependent

Mahmut Selman Sakar, Laurent Keller, Alexandre Tuleu, Matthias Rüegg, Nathalie Isabelle Karine Anne Stroeymeyt

2024

A model for mechanosensitive cell migration in dynamically morphing soft tissues

Mahmut Selman Sakar, Jaemin Kim, Erik Mailand, Nikolaos Bouklas

2023

Mahmut Selman Sakar

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Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation

A graduate laboratory experiment to study the dynamics of an acoustically levitated particle

Locomotion of Sensor‐Integrated Soft Robotic Devices Inside Sub‐Millimeter Arteries with Impaired Flow Conditions

Ultraflexible flow directed device and system

Dynamics of entrapped microbubbles with multiple openings

Compound micromachines powered by acoustic streaming

Pulsatile Flow-Induced Fatigue-Resistant Photopolymerizable Hydrogels for the Treatment of Intracranial Aneurysms

An acoustic levitation platform for high-content histological analysis of 3D tissue culture

A Robotic Surgery Platform for Automated Tissue Micromanipulation in Zebrafish Embryos

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

Surface and bulk stresses drive morphological changes in fibrous microtissues

Investigating Tissue Mechanics in vitro Using Untethered Soft Robotic Microdevices

A model for 3D deformation and reconstruction of contractile microtissues

Magnetic microrobots with addressable shape control

On-Board Mechanical Control Systems for Untethered Microrobots

Kinematic and dynamic analysis of the mosquito larvae gait

Optimization of Tail Geometry for the Propulsion of Soft Microrobots

Bioengineered Fascicle-Like Skeletal Muscle Tissue Constructs

Precise tactile stimulation of worker ants by a robotic manipulator reveals that individual responses are density‐ and context‐dependent

A model for mechanosensitive cell migration in dynamically morphing soft tissues