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Silvestro Micera

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Related publications (301)

Page 6 of 16

Chronic multichannel neural recordings from soft regenerative microchannel electrodes during gait

Sophie Marie Marthe Wurth, Stéphanie Lacour, Katherine Marie Musick, Silvestro Micera, Marco Capogrosso, Jacopo Rigosa

Reliably interfacing a nerve with an electrode array is one of the approaches to restore motor and sensory functions after an injury to the peripheral nerve. Accomplishing this with current technologies is challenging as the electrode-neuron interface ofte ...

Nature Publishing Group2015

A three-dimensional self-opening intraneural peripheral interface (SELINE)

Silvestro Micera

Objective. In this study we present the development and testing in a rat model of the self-opening neural interface (SELINE), a novel flexible peripheral neural interface. Approach. This polyimide-based electrode has a three-dimensional structure that prov ...

Iop Publishing Ltd2015

Investigating Ocular Movements and Vestibular Evoked Potentials for a Vestibular Neuroprosthesis: Response to Pulse Trains and Baseline Stimulation

Silvestro Micera

No adequate treatment currently exists for bilateral vestibulopathy, which can result in significant decreases of social and physical functioning. To improve patients' quality of life, vestibular neuroprostheses are being developed. Efficacy of current pro ...

Ieee2013

Evaluation of the effects of the Arm Light Exoskeleton on movement execution and muscle activities: a pilot study on healthy subjects

Elvira Pirondini, Silvestro Micera, Martina Coscia

Background: Exoskeletons for lower and upper extremities have been introduced in neurorehabilitation because they can guide the patient's limb following its anatomy, covering many degrees of freedom and most of its natural workspace, and allowing the contr ...

BioMed Central2016

A method and system for optimizing design, implantation, and stimulation protocols of electrodes stimulating the nervous system

Silvestro Micera, Simone Romeni

A method for optimizing at least one of a geometry, an implantation procedure, and/or stimulation protocol of one or more electrodes for an electrical stimulation of a target structure in a nervous system of a living being by a computer device, the method ...

2024

Detecting Slipping-Like Perturbations by Using Adaptive Oscillators

Silvestro Micera

This study introduces a novel algorithm to detect unexpected slipping-like perturbations based on the comparison between actual leg joint angles and those predicted by a pool of adaptive oscillators. The approach grounds on the hypothesis that during postu ...

Springer2015

Toward more naturalistic tactile sensors

Silvestro Micera

The human hand is a remarkable organ used every day to interact with the world. To achieve this, the hand is equipped with several sophisticated natural sensors that perceive touch, position, and temperature. Artificial systems that mimic the natural sense ...

American Association for the Advancement of Science2024

Direct activation of zebrafish neurons by ultrasonic stimulation revealed by whole CNS calcium imaging

Silvestro Micera

Objective. Ultrasounds (US) use in neural engineering is so far mainly limited to ablation through high intensity focused ultrasound, but interesting preliminary results show that low intensity low frequency ultrasound could be used instead to modulate neu ...

2020

Epidural electrical stimulation facilitates motor recovery in spinal cord injury involving the conus medullaris: A case study

Silvestro Micera, Simone Romeni

Background: Emerging research increasingly supports that epidural spinal cord electrical stimulation (EES) combined with neurorehabilitation can improve motor recovery in spinal cord injury (SCI) subjects. Patients with lesions involving the medullary cone ...

2025

Neurotechnology-aided interventions for upper limb motor rehabilitation in severe chronic stroke

José del Rocio Millán Ruiz, Silvestro Micera, Martina Coscia, Friedhelm Christoph Hummel, Maximilian Jonas Wessel

Upper limb motor deficits in severe stroke survivors often remain unresolved over extended time periods. Novel neurotechnologies have the potential to significantly support upper limb motor restoration in severely impaired stroke individuals. Here, we revi ...

2019

Soft Transfemoral Prosthetic Socket With Sensing and Augmenting Feedback: A Case Study

Silvestro Micera

In lower limb prostheses, the physical interface constituted by the socket is a crucial component for the device success. This work proposes a new design based on a rigid frame integrated into a silicone structure which allows for a more comfortable biomec ...

Piscataway2024

Tutorial: a computational framework for the design and optimization of peripheral neural interfaces

Silvestro Micera, Giacomo Valle, Simone Romeni

Peripheral neural interfaces have been successfully used in the recent past to restore sensory-motor functions in disabled subjects and for the neuromodulation of the autonomic nervous system. The optimization of these neural interfaces is crucial for ethi ...

NATURE RESEARCH2020

A modular strategy for next-generation upper-limb sensory-motor neuroprostheses

Solaiman Shokur, Giuseppe Schiavone, Silvestro Micera

Neuroprosthetics is a discipline that aims at restoring lost functions to people affected by a variety of neurological disorders or neuro-traumatic lesions. It combines the expertise of computer science and electrical, mechanical, and micro/nanotechnology ...

ELSEVIER2021

Compliant peripheral nerve interfaces

Stéphanie Lacour, Silvestro Micera, Outman Akouissi, Valentina Marie Paggi

Peripheral nerve interfaces (PNIs) record and/or modulate neural activity of nerves, which are responsible for conducting sensory-motor information to and from the central nervous system, and for regulating the activity of inner organs. PNIs are used both ...

IOP PUBLISHING LTD2021

An Event-Driven Closed-Loop System for Real-Time FES Control

Silvestro Micera, Andrea Crema, Danilo Demarchi

Active functional rehabilitation procedures, exoskeleton application and prosthesis employment are essential tools for the society life reinstatement of subjects affected by neuromuscular disorders or victims of serious physical accident. In this paper we ...

IEEE2019

Automated Selectivity-Driven Algorithm for Transcutaneous Spinal Cord Stimulation

Mohamed Bouri, Solaiman Shokur, Silvestro Micera, Riccardo Carpineto, Mouhamed Zorkot

Spinal cord injury (SCI) impairs motor function and quality of life. Transcutaneous Spinal Cord Stimulation (tSCS) is a non-invasive method to restore motor function by activating spinal circuits below the lesion. However, its effectiveness is limited by i ...

IEEE2025

Spatio-temporal structure of single neuron subthalamic activity identifies DBS target for anesthetized Tourette syndrome patients

Silvestro Micera

Objective. Deep brain stimulation (DBS) of basal ganglia effectively tackles motor symptoms of movement disorders such as Tourette syndrome (TS). The precise location of target stimulation site determines the range of clinical outcome in DBS patients, and ...

IOP PUBLISHING LTD2019

Corticospinal neuroprostheses to restore locomotion after spinal cord injury

José del Rocio Millán Ruiz, Stéphanie Lacour, Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Marco Bonizzato, Janine Beauparlant, Eduardo Martin Moraud, Pavel Musienko, David Allenson Borton

In this conceptual review, we highlight our strategy for, and progress in the development of corticospinal neuroprostheses for restoring locomotor functions and promoting neural repair after thoracic spinal cord injury in experimental animal models. We spe ...

Elsevier2014

Biomaterials. Electronic dura mater for long-term multimodal neural interfaces

Tomislav Milekovic, Léonie Asboth, Jérôme Gandar, Nicolas Vachicouras, Stéphanie Lacour, Arthur Edouard Hirsch, Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Quentin Barraud, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Natalia Pavlova

The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protectiv ...

American Association for the Advancement of Science2015

Cortical reactive balance responses to unexpected slippages while walking: a pilot study

Silvestro Micera

Understanding how the human brain cortex behaves when the dynamical balance is unexpectedly challenged can be useful to enable fall prevention strategies during daily activities. In this respect, we designed and tested a novel methodological approach to ea ...

IEEE2019