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Silvestro Micera

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Related publications (301)

Page 5 of 16

Degradation of EEG microstates patterns in subjective cognitive decline and mild cognitive impairment: Early biomarkers along the Alzheimer's Disease continuum?

Silvestro Micera

Alzheimer's disease (AD) pathological changes may begin up to decades earlier than the appearance of the first symptoms of cognitive decline. Subjective cognitive decline (SCD) could be the first pre-clinical sign of possible AD, which might be followed by ...

ELSEVIER SCI LTD2023

Organ Neuroprosthetics: Connecting Transplanted and Artificial Organs with the Nervous System

Silvestro Micera

Implantable neural interfaces with the central and peripheral nervous systems are currently used to restore sensory, motor, and cognitive functions in disabled people with very promising results. They have also been used to modulate autonomic activities to ...

Wiley2024

Combined Rehabilitation Promotes the Recovery of Structural and Functional Features of Healthy Neuronal Networks after Stroke

Silvestro Micera

Rehabilitation is considered the most effective treatment for promoting the recovery of motor deficits after stroke. One of the most challenging experimental goals is to unambiguously link brain rewiring to motor improvement prompted by rehabilitative ther ...

2019

A Robotic System for Adaptive Training and Function Assessment of Forelimb Retraction in Mice

Silvestro Micera

Rodent models are decisive for translational research in healthy and pathological conditions of motor function thanks to specific similarities with humans. Here, we present an upgraded version of the M-Platform, a robotic device previously designed to trai ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2018

Using Low-Power, Low-Cost IoT Processors in Clinical Biosignal Research: an In-depth Feasibility Check

Silvestro Micera, Fiorenzo Artoni

Research on biosignal (ExG) analysis is usually performed with expensive systems requiring connection with external computers for data processing. Consumer-grade low-cost wearable systems for bio-potential monitoring and embedded processing have been prese ...

IEEE2020

EEG topographies provide subject-specific correlates of motor control

José del Rocio Millán Ruiz, Dimitri Nestor Alice Van De Ville, Elvira Pirondini, Silvestro Micera, Martina Coscia, Jesús Minguillón Campos

Electroencephalography (EEG) of brain activity can be represented in terms of dynamically changing topographies (microstates). Notably, spontaneous brain activity recorded at rest can be characterized by four distinctive topographies. Despite their well-es ...

Nature Research2017

A Novel 3D-Printed/Porous Conduit with Tunable Properties to Enhance Nerve Regeneration Over the Limiting Gap Length

Silvestro Micera

Engineered grafts constitute an alternative to autologous transplant for repairing severe peripheral nerve injuries. However, current clinically available solutions have substantial limitations and are not suited for the repair of long nerve defects. A nov ...

Wiley2023

Engagement of the Rat Hindlimb Motor Cortex across Natural Locomotor Behaviors

Silvestro Micera, Grégoire Courtine, Janine Beauparlant, Lucia Florinda Friedli Wittler, Julie Kreider, Jacopo Rigosa

Contrary to cats and primates, cortical contribution to hindlimb locomotor movements is not critical in rats. However, the importance of the motor cortex to regain locomotion after neurological disorders in rats suggests that cortical engagement in hindlim ...

Soc Neuroscience2016

An Investigation of Manifold-Based Direct Control for a Brain-to-Body Neural Bypass

Solaiman Shokur, Silvestro Micera, Evgenia Vladimirova Roussinova

Objective: Brain-body interfaces (BBIs) have emerged as a very promising solution for restoring voluntary hand control in people with upper-limb paralysis. The BBI module decoding motor commands from brain signals should provide the user with intuitive, ac ...

Ieee-Inst Electrical Electronics Engineers Inc2024

Uncontrolled manifold analysis of the effects of a perturbation-based training on the organization of leg joint variance in cerebellar ataxia

Silvestro Micera

Walking patterns of persons affected by cerebellar ataxia (CA) are characterized by wide stride-to-stride variability ascribable to: the background pathology-related sensory-motor noise; the motor redundancy, i.e., an excess of elemental degrees of freedom ...

SPRINGER2021

An attention-based deep learning approach for the classification of subjective cognitive decline and mild cognitive impairment using resting-state EEG

Silvestro Micera

Objective. This study aims to design and implement the first deep learning (DL) model to classify subjects in the prodromic states of Alzheimer's disease (AD) based on resting-state electroencephalographic (EEG) signals. Approach. EEG recordings of 17 heal ...

IOP Publishing Ltd2023

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Léonie Asboth, Jérôme Gandar, Stéphanie Lacour, Arthur Edouard Hirsch, Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Quentin Barraud, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Natalia Pavlova, Julie Kreider, Laetitia Danielle Philippine Baud, Jocelyne Bloch

Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans. However, the physiological principles underlying the effect of this intervention remain poorly understood, which has limited the ther ...

Nature Publishing Group2016

A Computational Framework for the Design of Spinal Neuroprostheses

Silvestro Micera, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch

Severe Spinal Cord Injury (SCI) alters the communication between supra-spinal centers and the sensorimotor networks coordinating limb movements, which are usually located below the injury. Epidural electrical stimulation of lumbar segments has shown the ab ...

Springer International Publishing Ag2017

Neural Stimulation Hardware for the Selective Intrafascicular Modulation of the Vagus Nerve

Stéphanie Lacour, Silvestro Micera, Valentina Marie Paggi

The neural stimulation of the vagus nerve is able to modulate various functions of the parasympathetic response in different organs. The stimulation of the vagus nerve is a promising approach to treating inflammatory diseases, obesity, diabetes, heart fail ...

Ieee-Inst Electrical Electronics Engineers Inc2023

Shared human–robot proportional control of a dexterous myoelectric prosthesis

Aude Billard, Edoardo D'Anna, Nicolas Sommer, Silvestro Micera, Emanuele Formento, Saurav Aryan, Vincent Alexandre Mendez, Francesco Maria Petrini, Fiorenzo Artoni, Katie Zhi Zhuang

Myoelectric prostheses allow users to recover lost functionality by controlling a robotic device with their remaining muscle activity. Such commercial devices can give users a high level of autonomy, but still do not approach the dexterity of the intact hu ...

2019

Functional imaging of rostrocaudal spinal activity during upper limb motor tasks

Dimitri Nestor Alice Van De Ville, Roberto Martuzzi, Nawal Noëlle Kinany, Elvira Pirondini, Silvestro Micera

The spinal cord is the main interface between the brain and the periphery. It notably plays a central role in motor control, as spinal motoneurons activate skeletal muscles involved in voluntary movements. Yet, the spinal mechanisms underlying human moveme ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2019

Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury

Silvestro Micera, Marco Bonizzato

A spinal cord injury usually spares some components of the locomotor circuitry. Deep brain stimulation (DBS) of the midbrain locomotor region and epidural electrical stimulation of the lumbar spinal cord (EES) are being used to tap into this spared circuit ...

Nature Research2021

Exploring Skill Generalization with an Extra Robotic Arm for Motor Augmentation

Solaiman Shokur, Silvestro Micera, Giulia Dominijanni, Hugo Nicolas Victor Dirat

Recent research demonstrates that naïve users can be trained to perform complex motor tasks, including trimanual activities, using an extra robotic arm (XRA). While previous studies show task‐specific improvements with XRAs, it remains uncertain whether sk ...

Wiley2025

Intrafascicular peripheral nerve stimulation produces fine functional hand movements in primates

Sophie Marie Marthe Wurth, Marion Aimée Geneviève Badi-Dubois, Silvestro Micera, Grégoire Courtine, Evgenia Vladimirova Roussinova, Simon Borgognon, Ilaria Scarpato

Restoring dexterous hand control is critical for people with paralysis. Approaches based on surface or intramuscular stimulation provide limited finger control, generate insufficient force to recover functional movements, and require numerous electrodes. H ...

AMER ASSOC ADVANCEMENT SCIENCE2021

A Software Tool for the Real-Time in Vivo Evaluation of Neural Electrodes' Selectivity

Silvestro Micera, Stanisa Raspopovic, Francesco Maria Petrini, Ivo Strauss

High neural selectivity is an important indicator of how well a neural electrode will perform in a clinical setup. Among other factors, neural selectivity of an electrode strongly depends on its implant location. Today, the neural selectivity is evaluated ...

IEEE2021