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Silvestro Micera

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Related publications (301)

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Wearable Robotics for Impaired Upper-Limb Assistance and Rehabilitation: State of the Art and Future Perspectives

Silvestro Micera

Despite more than thirty-five years of research on wearable technologies to assist the upper-limb and a multitude of promising preliminary results, the goal of restoring pre-impairment quality of life of people with physical disabilities has not been fully ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

Neural signal recording and processing in somatic neuroprosthetic applications. A review

Silvestro Micera, Stanisa Raspopovic

Neurointerfaces have acquired major relevance as both rehabilitative and therapeutic tools for patients with spinal cord injury, limb amputations and other neural disorders. Bidirectional neural interfaces are a key component for the functional control of ...

ELSEVIER2020

Decoding bladder state from pudendal intraneural signals in pigs

Silvestro Micera, Stéphanie Lacour, Ivo Strauss, Valentina Marie Paggi, Leonardo Pollina

Neuroprosthetic devices used for the treatment of lower urinary tract dysfunction, such as incontinence or urinary retention, apply a pre-set continuous, open-loop stimulation paradigm, which can cause voiding dysfunctions due to neural adaptation. In the ...

2023

Wearable High-Density MXene-Bioelectronics for Neuromuscular Diagnostics, Rehabilitation, and Assistive Technologies

Silvestro Micera

High-density surface electromyography (HDsEMG) allows noninvasive muscle monitoring and disease diagnosis. Clinical translation of current HDsEMG technologies is hampered by cost, limited scalability, low usability, and minimal spatial coverage. Here, this ...

WILEY-V C H VERLAG GMBH2022

High-frequency epidural electrical stimulation reduces spasticity and facilitates walking recovery in patients with spinal cord injury

Silvestro Micera, Simone Romeni

Spinal cord injury (SCI) causes severe motor and sensory deficits, and there are currently no approved treatments for recovery. Nearly 70% of patients with SCI experience pathological muscle cocontraction and spasticity, accompanied by clinical signs such ...

AMER ASSOC ADVANCEMENT SCIENCE2025

Hybrid Human-Machine Interface for Gait Decoding Through Bayesian Fusion of EEG and EMG Classifiers

Silvestro Micera, Fiorenzo Artoni, Luca Tonin

Despite the advances in the field of brain computer interfaces (BCI), the use of the sole electroencephalography (EEG) signal to control walking rehabilitation devices is currently not viable in clinical settings, due to its unreliability. Hybrid interface ...

2020

Spatiotemporal Dynamics of the Cortical Responses Induced by a Prolonged Tactile Stimulation of the Human Fingertips

Silvestro Micera, Fiorenzo Artoni

The sense of touch is fundamental for daily behavior. The aim of this work is to understand the neural network responsible for touch processing during a prolonged tactile stimulation, delivered by means of a mechatronic platform by passively sliding a ridg ...

2017

Simultaneous decoding of cardiovascular and respiratory functional changes from pig intraneural vagus nerve signals

Silvestro Micera, Ivo Strauss, Simone Romeni

Objective. Bioelectronic medicine is opening new perspectives for the treatment of some major chronic diseases through the physical modulation of autonomic nervous system activity. Being the main peripheral route for electrical signals between central nerv ...

IOP PUBLISHING LTD2021

Machine-learning predictor of nerve fiber firing rate allows the automatic optimization of electrical stimulation protocols

Silvestro Micera, Simone Romeni, Gabriele Marino

Computational models have been widely employed to study the electrical stimulation of the nervous system. Still, most applications either study fundamental mechanisms underlying stimulation, or address qualitative scientific questions. When quantitative qu ...

IEEE2023

Biomimetic Intraneural Sensory Feedback Enhances Sensation Naturalness, Tactile Sensitivity, and Manual Dexterity in a Bidirectional Prosthesis

Silvestro Micera, Giulio Rognini, Ivo Strauss, Giacomo Valle, Francesco Maria Petrini, Edoardo D'Anna

Peripheral intraneural stimulation can provide tactile information to amputees. However, efforts are still necessary to identify encoding strategy eliciting percepts that are felt as both natural and effective for prosthesis control. Here we compared the n ...

2018

Microneurography as a tool to develop decoding algorithms for peripheral neuro-controlled hand prostheses

Silvestro Micera, Marco Capogrosso, Stanisa Raspopovic, Francesco Maria Petrini, Jacopo Rigosa

Background:The usability of dexterous hand prostheses is still hampered by the lack of natural and effective control strategies. A decoding strategy based on the process-ing of descending efferent neural signals recorded using peripheral neural interfaces ...

2019

All-Polymer Printed Low-Cost Regenerative Nerve Cuff Electrodes

Silvestro Micera

Neural regeneration after lesions is still limited by several factors and new technologies are developed to address this issue. Here, we present and test in animal models a new regenerative nerve cuff electrode (RnCE). It is based on a novel low-cost fabri ...

FRONTIERS MEDIA SA2021

A data-driven polynomial approach to reproduce the scar tissue outgrowth around neural implants

Silvestro Micera

Despite the huge complexity of the foreign body reaction, a quantitative assessment over time of the scar tissue thickness around implanted materials is needed to figure out the evolution of neural implants for long times. A data-driven approach, based on ...

SPRINGER2020

Quantitative Kinematic Characterization of Reaching Impairments in Mice After a Stroke

Silvestro Micera

Background and Objective. Kinematic analysis of reaching movements is increasingly used to evaluate upper extremity function after cerebrovascular insults in humans and has also been applied to rodent models. Such analyses can require time-consuming frame- ...

Sage Publications Inc2015

Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve

Silvestro Micera, Diego Ghezzi, Fiorenzo Artoni, Paola Vagni, Vivien Gaillet

Retinal prostheses can restore a functional form of vision in patients affected by dystrophies of the outer retinal layer. Beyond clinical utility, prostheses for the stimulation of the optic nerve, the visual thalamus or the visual cortex could also serve ...

2020

Connectivity Measures Differentiate Cortical and Subcortical Sub-Acute Ischemic Stroke Patients

Silvestro Micera

Brain lesions caused by cerebral ischemia lead to network disturbances in both hemispheres, causing a subsequent reorganization of functional connectivity both locally and remotely with respect to the injury. Quantitative electroencephalography (qEEG) meth ...

FRONTIERS MEDIA SA2021

Model-based variables for the kinematic assessment of upper-extremity impairments in post-stroke patients

Silvestro Micera, Elvira Pirondini

Background: Common scales for clinical evaluation of post-stroke upper-limb motor recovery are often complemented with kinematic parameters extracted from movement trajectories. However, there is no a general consensus on which parameters to use. Moreover, ...

BioMed Central2016

A One-Step Biofunctionalization Strategy of Electrospun Scaffolds Enables Spatially Selective Presentation of Biological Cues

Silvestro Micera

To recapitulate the heterogeneous complexity of tissues in the human body with synthetic mimics of the extracellular matrix (ECM), it is important to develop methods that can easily allow the selective functionalization of defined spatial domains. Here, a ...

Wiley2020

Remapping Wetness Perception in Upper Limb Amputees

Nerea-Isabel Carbonell Muñoz, Silvestro Micera, Solaiman Shokur, Outman Akouissi, Jonathan Louis Muheim, Maria Ploumitsakou

Recent research has made remarkable strides in restoring sensory feedback for prosthetic users, including tactile, proprioceptive, and thermal feedback. Herein, a sensory modality that has been largely neglected is explored: the ability to perceive wetness ...

Wiley2024

Optimization frameworks for bespoke sensory encoding in neuroprosthetics

Silvestro Micera, Solaiman Shokur, Franklin Leong

Restoring natural sensation via neuroprosthetics relies on the possibility of encoding complex and nuanced information. For example, an ideal brain–machine interface with sensory feedback would provide the user with sensation about movement, pressure, curv ...

AIP Publishing2025