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Michele De Palma

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Related publications (127)

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Partners in crime: VEGF and IL-4 conscript tumour-promoting macrophages

Michele De Palma

Tumour-associated macrophages (TAMs) foster tumour progression by several mechanisms, including the promotion of angiogenesis, tissue remodelling, and immunosuppression. Such pro-tumoural activities are thought to be executed by TAM subtypes that harbour f ...

Wiley-Blackwell2012

Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinase

Michele De Palma, Mario Leonardo Squadrito

M1 activation of macrophages promotes inflammation and immunity to intracellular pathogens, whereas M2 macrophage activation promotes resolution of inflammation, wound healing, and tumor growth. These divergent phenotypes are characterized, in part, by the ...

American Association of Immunologists ; Oxford University Press2011

Search for high-mass exclusive diphoton production with tagged protons in proton-proton collisions at √s=13 TeV

Emilio Perez, Thomas L. Sterling, Jiahui Fan, Mateusz Adam Dabrowski, Ian Smith, Matthias Finger, Jian Zhao, Jan Steggemann, Konstantin Androsov, Qian Wang, Michele De Palma, Anna Mascellani, Yi Zhang, Jian Wang, Joanna Malgorzata Wanczyk, Pedro Camilo de Oliveira e Silva, Rakesh Chawla, Myun Sik Kim, Thomas Mountford, Varun Sharma, Mirko Kovac, Shivom Sharma, Chang-Hyun Park, Jae-Woo Choi, Rahul Kumar Gupta, Hua Zhang, Mike Seidel, Joo Yeon Kim, Matteo Galli, Matthias Wolf, James Gonzalo King, Shubhajit Das, Xiaoqiang Wang, Zhenyu Wang, Xin Chen, Gabriele Grosso, Rishi Sharma, Chia-Chun Chen, Jia Liu, Jung Eung Park, Ekaterina Kuznetsova, Siyuan Wang, Mithlesh Kumar, Chenyang Wang, Xiaoxin Gao, Aman Sharma, Junyin Zhang, Subham Choudhury, Seonwoo Lee, Mingyang Liu, Davide Di Croce, Patrick Berger, Jordy Daniel Müller, Marie Jane Francine Jones, Wei-Hsiang Lin, Wanyun Xie, Hyungjun Lee, Vu Trung Tin Nguyen, Junfeng Xiao, Wanting Jin, Zeming Chen, Maria Isabel Cordero Campana, Young Min Kim, Ling Zhou, Weilin Li, Haoze He, Andrea Santoro, Thomas Ka Chung Lam, Özdemir Can Kara, Bokyoung Kim, Notash Shafiei, Shaohui Yang, Haiyuan Wang, Youngro Lee, Dong Hyun Kim, Florian Hartmann, Muhammad Awais Naeem, Lu Wang, Shailesh Mishra, Tianqi Liu, Zhuan Shi, Leyu Zhang, Yihong Chen, Changliang Li, Sudipto Sarkar, Fang Wang, Yikai Yang, Boya Wang, Guoyuan Liu, Venu Gopal Agarwal, Zihan Wu, Hong-Bin Yang, Yunzhen Yao, Chenxu Liu, Xiaowu Sun, Zihan Hu

A search is presented for high-mass exclusive diphoton production via photon-photon fusion in proton-proton collisions at root s = 13 TeV in events where both protons survive the interaction. The analysis utilizes data corresponding to an integrated lumino ...

AMER PHYSICAL SOC2024

Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

Michele De Palma, Ece Kadioglu, Nicolo Rigamonti, Damya Laoui, Céline Wyser Rmili

Pathological angiogenesis is a hallmark of cancer and a therapeutic target. Vascular endothelial growth factor A (VEGFA) and angiopoietin-2 (ANGPT2; also known as ANG2) are proangiogenic cytokines that sustain tumor angiogenesis and limit antitumor immunit ...

American Association for the Advancement of Science2017

EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens

Michele De Palma, Chiara Cianciaruso, Mario Leonardo Squadrito

We describe a lentivirus-encoded chimeric receptor, termed extracellular vesicle (EV)-internalizing receptor (EVIR), which enables the selective uptake of cancer-cell-derived EVs by dendritic cells (DCs). The EVIR enhances DC presentation of EV-associated ...

Nature Publishing Group2018

Computing heteroclinic orbits using adjoint-based methods

Mirko Farano, Michele De Palma, Tobias Schneider

Transitional turbulence in shear flows is supported by a network of unstable exact invariant solutions of the Navier-Stokes equations. The network is interconnected by heteroclinic connections along which the turbulent trajectories evolve between invariant ...

Cambridge University Press2018

Proangiogenic Tie2(+) macrophages infiltrate human and murine endometriotic lesions and dictate their growth in a mouse model of the disease

Michele De Palma, Daniela Biziato

Endometriosis affects women of reproductive age, causing infertility and pain. Although immune cells are recruited in endometriotic lesions, their role is unclear. Tie2-expressing macrophages (TEMs) have nonredundant functions in promoting angiogenesis and ...

2011

Red Listing African Goliath Beetles: Assessing Threats and Conservation Needs

Michele De Palma

The loss of biodiversity is one of the most critical global environmental challenges, driven by deforestation, habitat fragmentation and overexploitation. This study focuses on the biodiversity crisis in Africa, with particular emphasis on the conservation ...

2025

Harnessing deep learning to detect bronchiolitis obliterans syndrome from chest CT

Pascal Fua, Michele De Palma, Nahal Mansouri, Jakub Jan Gwizdala

BackgroundBronchiolitis Obliterans Syndrome (BOS), a fibrotic airway disease that may develop after lung transplantation, conventionally relies on pulmonary function tests (PFTs) for diagnosis due to limitations of CT imaging. Deep neural networks (DNNs) h ...

SPRINGERNATURE2025

Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis

Michele De Palma

Epidermal growth factor receptor (EGFR) is a known diagnostic and, although controversial, prognostic marker of human glioblastoma multiforme (GBM). However, its functional role and biological significance in GBM remain elusive. Here, we show that multiple ...

2010

Primary human and rat beta cells release the intracellular autoantigens GAD65, IA-2 and proinsulin in exosomes together with cytokine-induced enhancers of immunity

Jeffrey Alan Hubbell, Melody Swartz, Michele De Palma, Davide Demurtas, Romain Hamelin, Sachiko Hirosue, Chiara Cianciaruso, Edward Allen Phelps, Steinunn Baekkeskov Hanahan

The target autoantigens in several organ-specific autoimmune diseases, including type 1 diabetes (T1D), are intracellular membrane proteins, whose initial encounter with the immune system is poorly understood. Here we propose a new model for how these prot ...

American Diabetes Association2017

Targeting macrophages sensitizes chronic lymphocytic leukemia to apoptosis and inhibits disease progression

Michele De Palma

The role of monocytes/macrophages in the development and progression of chronic lymphocytic leukemia (CLL) is poorly understood. Transcriptomic analyses show that monocytes/macrophages and leukemic cells cross talk during CLL progression. Macrophage deplet ...

Elsevier2016

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors

Michele De Palma

Bone marrow-derived cells contribute to tumor angiogenesis. Here, we demonstrate that monocytes expressing the Tie2 receptor (Tie2-expressing monocytes [TEMs]) (1) are a distinct hematopoietic lineage of proangiogenic cells, (2) are selectively recruited t ...

Elsevier2005

Transplanted neural stem/precursor cells instruct phagocytes and reduce secondary tissue damage in the injured spinal cord

Michele De Palma, Daniela Biziato

Transplanted neural stem/precursor cells possess peculiar therapeutic plasticity and can simultaneously instruct several therapeutic mechanisms in addition to cell replacement. Here, we interrogated the therapeutic plasticity of neural stem/precursor cells ...

2012

T cell–induced CSF1 promotes melanoma resistance to PD1 blockade

Michele De Palma, George Coukos, Krisztian Homicsko, Sina Nassiri

Colony-stimulating factor 1 (CSF1) is a key regulator of monocyte/macrophage differentiation that sustains the protumorigenic functions of tumor-associated macrophages (TAMs). We show that CSF1 is expressed in human melanoma, and patients with metastatic m ...

2018

Bimodal CD40/Fas-Dependent Crosstalk between iNKT Cells and Tumor-Associated Macrophages Impairs Prostate Cancer Progression

Michele De Palma

Heterotypic cellular and molecular interactions in the tumor microenvironment (TME) control cancer progression. Here, we show that CD1d-restricted invariant natural killer (iNKT) cells control prostate cancer (PCa) progression by sculpting the TME. In a mo ...

2018

Living With Hyraxes: Biogeography and Comparative Ecology of West African Fornasinius Beetles

Michele De Palma

Among the flower beetles (Scarabaeidae, Cetoniinae), the Goliathini comprise several genera of medium- and large-sized beetles widely distributed in sub-Saharan Africa. In this tribe, the genus Fornasinius Bertoloni, 1853, includes two species found in Wes ...

Wiley2024

Precision targeting of tumor macrophages with a CD206 binding peptide

Michele De Palma, Mario Leonardo Squadrito

Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse. Here, we describe a peptide that selectively targets MRC1-express ...

Nature Research2017

TIE2-expressing monocytes/macrophages regulate revascularization of the ischemic limb

Michele De Palma, Daniela Biziato

A third of patients with critical limb ischemia (CLI) will eventually require limb amputation. Therapeutic neovascularization using unselected mononuclear cells to salvage ischemic limbs has produced modest results. The TIE2-expressing monocytes/macrophage ...

Wiley-Blackwell2013

Role of haematopoietic cells and endothelial progenitors in tumour angiogenesis

Michele De Palma

Bone marrow-derived cells include haematopoietic cell lineages and the recently described endothelial progenitor cells (EPCs). It has been recently emphasised that these marrow-derived cells contribute to tumour angiogenesis, and different mechanisms have ...

2006