Publication

EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens

Michele De Palma, Chiara Cianciaruso, Mario Leonardo Squadrito
2018
Journal Articles

Abstract

We describe a lentivirus-encoded chimeric receptor, termed extracellular vesicle (EV)-internalizing receptor (EVIR), which enables the selective uptake of cancer-cell-derived EVs by dendritic cells (DCs). The EVIR enhances DC presentation of EV-associated tumor antigens to CD8+ T cells primarily through MHCI recycling and cross-dressing. EVIRs should facilitate exploring the mechanisms and implications of horizontal transfer of tumor antigens to antigen-presenting cells.

Official source

https://infoscience.epfl.ch/entities/publication/64a05f5d-d4f5-40b2-b4f9-70a697c60f0a

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EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens

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