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Michele De Palma

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Publications associées (128)

Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth

Mauro Delorenzi, Stefanie Siegert, Pascale Anderle Pedone, Nadine Fournier, Sina Nassiri, François Renevey, Michele De Palma, Mario Leonardo Squadrito, Simone Ragusa

Stem and progenitor cells residing in the intestinal crypts drive the majority of colorectal cancers (CRCs), yet vascular contribution to this niche remains largely unexplored. Vascular endothelial growth factor A (VEGFA) is a key driver of physiological a ...

Springernature2022

Dendritic cell cross-dressing and tumor immunity

Michele De Palma, Amaia Martinez Usatorre

In addition to direct and cross-presentation, dendritic cells (DCs) can present tumor antigens (TAs) to T cells via a hitherto poorly understood mechanism called "cross-dressing." DC cross-dressing involves the acquisition of preformed peptide-major histoc ...

WILEY2022

Boosting dendritic cell nanovaccines

Michele De Palma, Yahya Mohammadzadeh

A preclinical study reports a platform for the generation of dendritic cell-derived nanovesicles with enhanced immunostimulatory function, which demonstrate promising antitumoural activity in mouse models and might overcome some of the shortcomings of earl ...

Nature Portfolio2022

Disentangling the complexity of tumor-derived extracellular vesicles

Tim Beltraminelli, Michele De Palma, Caleb Ricardo Perez

The tumor microenvironment encompasses an intertwined ensemble of both transformed cancer cells and non-transformed host cells, which together establish a signaling network that regulates tumor progression. By conveying both homo- and heterotypic cell-to-c ...

2021

Taxonomic revision of the Eudicella White, 1839 complex, with description of three new subgenera

Michele De Palma

Morphological and DNA barcoding analysis of representative taxa in the Eudicella White complex identified five distinct subgenera, three of which are established herein: Eudicella (Coelorrhinella) n. subg., Eudicella (Aneurhina) n. subg., and Eudicella (Ce ...

2021

Determinants of tumor resistance to anti-angiogenic immunotherapy in mouse models of Kras-mutant NSCLC

Ioanna Keklikoglou, Sina Nassiri, Etienne Meylan, Michele De Palma, Ece Kadioglu, Chiara Cianciaruso, Bruno Torchia, Alan Nicolas Thierry Guichard, Amaia Martinez Usatorre

AMER ASSOC CANCER RESEARCH2021

Macrophage depletion induces edema through release of matrix-degrading proteases and proteoglycan deposition

Michele De Palma

Colony-stimulating factor 1 receptor (CSF1R) blockade abates tumor-associated macrophage (TAM) infiltrates and provides marked clinical benefits in diffuse-type tenosynovial giant cell tumors. However, facial edema is a common adverse event associated with ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Targeting LRG1 boosts immunotherapy

Amanda Waite Lund, Michele De Palma

Vascular normalization therapy has the potential to facilitate drug delivery and lymphocyte infiltration in tumors. Yet, optimal targets and dosage regimens remain elusive. In this issue of Med, O’Connor et al. show that inhibition of LRG1 stabilizes the t ...

2021

Taxonomic notes on Caelorrhina Hope, 1841, Coelorrhina Burmeister, 1842 and related genera

Michele De Palma

We here review the taxonomic standing of several generic names in the African Cetoniinae and re-establish Coelorrhina Burmeister, 1842 (= Cyprolais Thomson 1880 syn. nov.) as the first available name for Cetonia quadrimaculata Fabricius, 1781. ...

2021

Alzheimer's drug turns macrophages against cancer

Michele De Palma, Amaia Martinez Usatorre

NATURE PORTFOLIO2021

Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models

Ioanna Keklikoglou, Nadine Fournier, Sina Nassiri, Etienne Meylan, Michele De Palma, Ece Kadioglu, Chiara Cianciaruso, Bruno Torchia, Gael Luis Boivin, Alan Nicolas Thierry Guichard, Amaia Martinez Usatorre

Immune checkpoint blockade (ICB) with PD-1 or PD-L1 antibodies has been approved for the treatment of nonsmall cell lung cancer (NSCLC). However, only a minority of patients respond, and sustained remissions are rare. Both chemotherapy and antiangiogenic d ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Imaging-based spectrometer-less optofluidic biosensors based on dielectric metasurfaces for detecting extracellular vesicles

Michele De Palma, Hatice Altug, Chiara Cianciaruso, Filiz Yesilköy, Yasaman Jahani, Eduardo Romero Arvelo

Biosensors are indispensable tools for public, global, and personalized healthcare as they provide tests that can be used from early disease detection and treatment monitoring to preventing pandemics. We introduce single-wavelength imaging biosensors capab ...

Nature Research2021

The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner

Michele De Palma

Neuro-vascular communication is essential to synchronize central nervous system development. Here, we identify angiopoietin/Tie2 as a neuro-vascular signaling axis involved in regulating dendritic morphogenesis of Purkinje cells (PCs). We show that in the ...

CELL PRESS2021

All-dielectric Metasurfaces Enabling Imaging-based Real-time Biosensing

Michele De Palma, Hatice Altug, Chiara Cianciaruso, Yasaman Jahani, Eduardo Romero Arvelo

IEEE2021

Imaging-based Optofluidic Biosensors Enabled by All-dielectric metasurfaces

Michele De Palma, Hatice Altug, Chiara Cianciaruso, Yasaman Jahani, Eduardo Romero Arvelo

We present optofluidic label-free biosensors leveraging high quality-factor resonances emanated from bound-states-in-the-continuum and novel data processing. The sensors are based on imaging and offer solutions to remove sophisticated spectroscopy instrume ...

IEEE2021

Vascular reprogramming for enhancing cancer immunotherapy

Michele De Palma

AMER ASSOC CANCER RESEARCH2020

A LIGHTning Strike to the Metastatic Niche

Michele De Palma, Amaia Martinez Usatorre

Tumor-induced vascular alterations in distant organs have been linked to the spreading of cancer. In this issue of Cell Reports, He et al. (2019) show that targeting the cytokine LIGHT to the pulmonary vasculature prevents the establishment of lung metasta ...

2020

Optimized antiangiogenic reprogramming of the tumor microenvironment potentiates CD40 immunotherapy

Michele De Palma, Nicolo Rigamonti, Daniela Pais Ferreira, Alan Nicolas Thierry Guichard

Cancer immunotherapies are increasingly combined with targeted therapies to improve therapeutic outcomes. We show that combination of agonistic anti-CD40 with antiangiogenic antibodies targeting 2 proangiogenic factors, vascular endothelial growth factor A ...

2020

Biology and therapeutic targeting of tumour-associated macrophages

Tim Beltraminelli, Michele De Palma

Macrophages sustain tumour progression by facilitating angiogenesis, promoting immunosuppression, and enhancing cancer cell invasion and metastasis. They also modulate tumour response to anti-cancer therapy in pre-clinical models. This knowledge has motiva ...

WILEY2020

Pachytephraea attenboroughi n. gen., n. sp., an atypical small Cetoniine from Tanzania (Scarabaeidae, Cetoniinae)

Michele De Palma

Pachytephraea attenboroughi n. gen., n. sp. is described from Iringa Province in central Tanzania. A differential diagnosis with related genera is presented. ...

2020

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