Publications by Matteo Cornaglia

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Mitochondrial respiration is a key signature for the assessment of mitochondrial functioning and mitochondrial dysfunction is related to many diseases including metabolic syndrome and aging-associated conditions. Here, we present a microfluidic Caenorhabdi ...

In this work, we present a novel microfluidic approach to culture the nematode C. elegans from the onset of embryogenesis to the adult stage at single animal resolution. Our device allows high-throughput experimentation, high-resolution imaging, thereby pr ...

We introduce a new and simple microfluidic sorting device based on adjustable filter structures that can be easily tuned by external pressure for a specific size-dependent C. elegans worm sorting experiment. A single device can be used for selecting and so ...

We present a multiplexed and automated microfluidic platform for phenotyping of C. elegans during their full lifespan and at high-throughput. We used the fluorescent hsp-6::gfp strain of worms and performed experiments to observe the effect of four differe ...

The invention discloses a microfluidic device for the culture, selection and/or analysis of sample organisms such as nematodes, as well as for other biological entities such as for instance animal embryos. The device features reservoirs, culture chambers a ...

A magnetic microparticle-based bioassay requires the separation of the microparticles from the sample matrix, after the microparticles have specifically captured the target of interest. For the implementation of such an assay in water-in-oil droplet segmen ...

We introduce a new modeling approach for understanding the fundamental principle of bead-based surface coverage immunoassays that rely on the specific interaction between surface-bound “small” magnetic beads (1 μm in diameter) and a flow of “large” magneti ...

Matteo Cornaglia

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Microfluidic system for Caenorhabditis elegans culture and oxygen consumption rate measurements

Automated High-Content Phenotyping Of The Nematode C. Elegans At Single Animal Resolution With A Microfluidic Platform

Size-dependent sorting of C. elegans nematodes through an adjustable microfluidic filter structure

A microfluidic platform for automated phenotyping during full lifespan of Caenorhabditis elegans at high-throughput

Microfluidic device, system and method for the study of organisms

An automated microfluidic platform for reversible immobilization and imaging of C. elegans

Separation of magnetic microparticles in segmented flow using asymmetric splitting regimes

A random-walk based model to explain ultrasensitive magnetic bead-based immunoassays

Magnetic microparticle based DNA extraction in a droplet microfluidic chip

Track C. Biomedical Instrumentation & Micro and Nano Systems