Publication

A random-walk based model to explain ultrasensitive magnetic bead-based immunoassays

Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Raphaël Etienne Jean Trouillon, Hüseyin Cumhur Tekin
2014
Conference Papers

Abstract

We introduce a new modeling approach for understanding the fundamental principle of bead-based surface coverage immunoassays that rely on the specific interaction between surface-bound “small” magnetic beads (1 μm in diameter) and a flow of “large” magnetic beads (3 μm in diameter). The latter ones carry target antigens and are simultaneously used as detection labels. This immunoassay technique allows attaining extremely low (attomolar) limits of detection, with strongly sub-linear dose-response curves, but the origin of these features remained unclear up to now. Our comprehensive theoretical model allows complete understanding of these unsolved issues.

Official source

https://infoscience.epfl.ch/entities/publication/0d6e38f0-6f8c-45de-8509-1d145fa27bf1

About this result

This page is automatically generated and may contain information that is not correct, complete, up-to-date, or relevant to your search query. The same applies to every other page on this website. Please make sure to verify the information with EPFL's official sources.

Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Raphaël Etienne Jean Trouillon, Hüseyin Cumhur Tekin
2014
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/0d6e38f0-6f8c-45de-8509-1d145fa27bf1

About this result

Related concepts (13)

Systems modeling

Systems modeling or system modeling is the interdisciplinary study of the use of models to conceptualize and construct systems in business and IT development. A common type of systems modeling is function modeling, with specific techniques such as the Functional Flow Block Diagram and IDEF0. These models can be extended using functional decomposition, and can be linked to requirements models for further systems partition.

Three-schema approach

The three-schema approach, or three-schema concept, in software engineering is an approach to building information systems and systems information management that originated in the 1970s. It proposes three different views in systems development, with conceptual modelling being considered the key to achieving data integration.

Conceptual model

A conceptual model is a representation of a system. It consists of concepts used to help people know, understand, or simulate a subject the model represents. In contrast, a physical model focuses on a physical object such as a toy model that may be assembled and made to work like the object it represents. The term may refer to models that are formed after a conceptualization or generalization process. Conceptual models are often abstractions of things in the real world, whether physical or social.

Related publications (2)

Early Prediction of Conceptual Understanding in Interactive Simulations

Christian Giang, Jade Maï L Cock, Tanja Christina Käser Jacober, Mirko Marras

Interactive simulations allow students to independently ex- plore scientific phenomena and ideally infer the underlying principles through their exploration. Effectively using such environments is challenging for many students and there- fore, adaptive gui ...

2021

The affinity precipitation for the isolation of biomolecules

Gisela Stocker Majd

Product isolation increasingly becomes a major bottleneck in molecular biotechnology. This is especially the case for the sensitive proteineous substances (recombinant proteins, antibodies) and lately also DNA, usually produced in low concentration. The cu ...

EPFL2007