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Matteo Cornaglia

Cette personne a quitté l’EPFL

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Publications associées (35)

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Magnetic Particle-Scanning for Ultrasensitive Immunodetection On-Chip

Martinus Adela Maria Gijs, Thomas Lehnert, Matteo Cornaglia, Hüseyin Cumhur Tekin, Raphaël Etienne Jean Trouillon

We describe the concept of magnetic particle-scanning for on-chip detection of biomolecules: a magnetic particle, carrying a low number of antigens (Ag's) (down to a single molecule), is transported by hydrodynamic forces and is subjected to successive sto ...

American Chemical Society2014

An automated microfluidic platform for long-term high-resolution imaging of C. elegans

Martinus Adela Maria Gijs, Johan Auwerx, Thomas Lehnert, Matteo Cornaglia, Laurent Mouchiroud, Govindan Narayanan Krishnamani, Marie-Pierre Meurville, Gopalan Hariharan Krishnamani

We describe a microfluidic platform for the automated culture, treatment and long-term highresolution imaging of Caenorhabditis elegans nematodes under normal physiological conditions. Our device features: (i) a microfluidic design tailored for the isolati ...

2014

Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models

Martinus Adela Maria Gijs, Johan Auwerx, Thomas Lehnert, Matteo Cornaglia, Laurent Mouchiroud, Vincenzo Sorrentino, Govindan Narayanan Krishnamani

Background: While many biological studies can be performed on cell-based systems, the investigation of molecular pathways related to complex human dysfunctions - e.g. neurodegenerative diseases - often requires long-term studies in animal models. The nemat ...

BioMed Central2016

System for optical detection and imaging of sub-diffraction-limited nano-objects

Martinus Adela Maria Gijs, Matteo Cornaglia, Hui Yang

Nano-objects (8) with feature size smaller than the classical Abbe's diffraction limit can be optically detected via a microlens (4) array configured in a miniaturized microfluidic device. A hydrophilic microwell (3) array in a hydrophobic layer (2) is fir ...

2016

Microfluidic system for Caenorhabditis elegans culture and oxygen consumption rate measurements

Martinus Adela Maria Gijs, Thomas Lehnert, Matteo Cornaglia, Roger Philippe Krenger

Mitochondrial respiration is a key signature for the assessment of mitochondrial functioning and mitochondrial dysfunction is related to many diseases including metabolic syndrome and aging-associated conditions. Here, we present a microfluidic Caenorhabdi ...

ROYAL SOC CHEMISTRY2020

Fine-tuning of magnetic and microfluidic viscous forces for specific magnetic bead-based immunocomplex formation

Martinus Adela Maria Gijs, Thomas Lehnert, Matteo Cornaglia, Hüseyin Cumhur Tekin

We investigate the working principle of a novel type of microfluidic sandwich immunoassay, as used for the detection of biomarkers. The heterogeneous assay is based on the specific interactions between an array of functionalized superparamagnetic beads and ...

American Institute of Physics2013

Automated High-Content Phenotyping Of The Nematode C. Elegans At Single Animal Resolution With A Microfluidic Platform

Martinus Adela Maria Gijs, Johan Auwerx, Matteo Cornaglia, Laurent Mouchiroud, Hüseyin Baris Atakan, Rongrong Xiang

In this work, we present a novel microfluidic approach to culture the nematode C. elegans from the onset of embryogenesis to the adult stage at single animal resolution. Our device allows high-throughput experimentation, high-resolution imaging, thereby pr ...

IEEE2019

Size-dependent sorting of C. elegans nematodes through an adjustable microfluidic filter structure

Martinus Adela Maria Gijs, Thomas Lehnert, Matteo Cornaglia, Li Dong

We introduce a new and simple microfluidic sorting device based on adjustable filter structures that can be easily tuned by external pressure for a specific size-dependent C. elegans worm sorting experiment. A single device can be used for selecting and so ...

2016

A microfluidic platform for automated phenotyping during full lifespan of Caenorhabditis elegans at high-throughput

Martinus Adela Maria Gijs, Johan Auwerx, Matteo Cornaglia, Laurent Mouchiroud, Hüseyin Baris Atakan

We present a multiplexed and automated microfluidic platform for phenotyping of C. elegans during their full lifespan and at high-throughput. We used the fluorescent hsp-6::gfp strain of worms and performed experiments to observe the effect of four differe ...

2017

Microfluidic device, system and method for the study of organisms

Martinus Adela Maria Gijs, Matteo Cornaglia, Daniel Migliozzi

The invention discloses a microfluidic device for the culture, selection and/or analysis of sample organisms such as nematodes, as well as for other biological entities such as for instance animal embryos. The device features reservoirs, culture chambers a ...

2016

An automated microfluidic platform for reversible immobilization and imaging of C. elegans

Martinus Adela Maria Gijs, Johan Auwerx, Thomas Lehnert, Matteo Cornaglia, Laurent Mouchiroud, Govindan Narayanan Krishnamani, Marie-Pierre Meurville, Gopalan Hariharan Krishnamani

2014

Separation of magnetic microparticles in segmented flow using asymmetric splitting regimes

Martinus Adela Maria Gijs, Matteo Cornaglia

A magnetic microparticle-based bioassay requires the separation of the microparticles from the sample matrix, after the microparticles have specifically captured the target of interest. For the implementation of such an assay in water-in-oil droplet segmen ...

Springer Heidelberg2015

A random-walk based model to explain ultrasensitive magnetic bead-based immunoassays

Martinus Adela Maria Gijs, Thomas Lehnert, Matteo Cornaglia, Hüseyin Cumhur Tekin, Raphaël Etienne Jean Trouillon

We introduce a new modeling approach for understanding the fundamental principle of bead-based surface coverage immunoassays that rely on the specific interaction between surface-bound “small” magnetic beads (1 μm in diameter) and a flow of “large” magneti ...

2014

Magnetic microparticle based DNA extraction in a droplet microfluidic chip

Martinus Adela Maria Gijs, Matteo Cornaglia

2014

Track C. Biomedical Instrumentation & Micro and Nano Systems

Johan Auwerx, Martinus Adela Maria Gijs, Thomas Lehnert, Laurent Mouchiroud, Matteo Cornaglia, Vincenzo Sorrentino, Alexis Pierre Henri Marette, Virginija Jovaisaite, Govindan Narayanan Krishnamani

De Gruyter2016