Publications by Carlotta Guiducci

Related publications (39)

Metal-Coated SU-8 Structures for High-Density 3-D Microelectrode Arrays

Carlotta Guiducci, Samuel Kilchenmann, Pietro Maoddi, Enrica Rollo

Electric fields can be effectively used to sense, manipulate, and move particles in lab-on-a-chip devices. Nevertheless, the throughput of such devices is a critical issue, which can be effectively improved by increasing the height of the microchannels. Fo ...

Institute of Electrical and Electronics Engineers2016

MarrowCellDLD: a microfluidic method for label-free retrieval of fragile bone marrow-derived cells

Lucie Marie Dominique Godot, Carlotta Guiducci, Gloria Porro

Functional bone marrow studies have focused primarily on hematopoietic progenitors, leaving limited knowledge about other fragile populations, such as bone marrow adipocytes (BMAds) and megakaryocytes. The isolation of these cells is challenging due to rup ...

Nature Portfolio2023

Prediction of Dispersion Rate of Airborne Nanoparticles in a Gas-Liquid Dual-Microchannel Separated by a Porous Membrane: A Numerical Study

Zohreh Sheidaei, Carlotta Guiducci

Recently, there has been increasing attention toward inhaled nanoparticles (NPs) to develop inhalation therapies for diseases associated with the pulmonary system and investigate the toxic effects of hazardous environmental particles on human lung health. ...

MDPI2022

Label-free identification of activated T lymphocytes through tridimensional microsensors on chip

Carlotta Guiducci, George Coukos, Alexandre Harari, Elena Bianchi, Enrico Tenaglia, Enrica Rollo

Label-free approaches to assess cell properties ideally suit the requirements of cell-based therapeutics, since they permit to characterize cells with minimal perturbation and manipulation, at the benefit of sample recovery and re-employment for treatment. ...

Elsevier2017

On‐chip technology for single‐cell arraying, electrorotation‐based analysis and selective release

Paul Karoly Otto Ery, Mohamed Zakarya Alsaid Ali Rashed, Carlotta Guiducci, Samuel Kilchenmann, Kevin Keim

This paper reports a method for label-free single-cell biophysical analysis of multiple cells trapped in suspension by electrokinetic forces. Tri-dimensional pillar electrodes arranged along the width of a microfluidic chamber define actuators for single c ...

2019

Real-time high-sensitivity impedance measurement interface for tethered BLM biosensor arrays

Giovanni De Micheli, Yusuf Leblebici, Horst Arthur Vogel, Luca Benini, Carlotta Guiducci, Yüksel Temiz, Samuel Terrettaz

This paper presents a switched-capacitor (SC) current integrator circuit for impedance measurement of tethered bilayer lipid membrane (tBLM) biosensors. The circuit comprises a small number of high performance components enabling enhanced experimental flex ...

2008

A Portable Setup for Molecular Detection by Transmission LSPR

Luca Benini, Carlotta Guiducci, Enrico Accastelli, Giulia Cappi, Fabio Mario Spiga

In the framework of bioanalytics and multiple array detection, we developed a fully portable and low-cost detection system based on Localized Surface Plasmon Resonance (LSPR) in a transmission configuration (T-LSPR). The transmission approach is suitable t ...

2012

Selective Retrieval of Individual Cells from Microfluidic Arrays Combining Dielectrophoretic Force and Directed Hydrodynamic Flow

Gabriele Gambardella, Bart Deplancke, Carlotta Guiducci, Jörn Pezoldt, Kevin Keim, Pierre-Emmanuel Marie Thiriet

Hydrodynamic-based microfluidic platforms enable single-cell arraying and analysis over time. Despite the advantages of established microfluidic systems, long-term analysis and proliferation of cells selected in such devices require off-chip recovery of ce ...

MDPI2020

Overview of Micro- and Nano-Technology Tools for Stem Cell Applications: Micropatterned and Microelectronic Devices

Carlotta Guiducci

In the past few decades the scientific community has been recognizing the paramount role of the cell microenvironment in determining cell behavior. In parallel, the study of human stem cells for their potential therapeutic applications has been progressing ...

Mdpi Ag2012

Electrokinetic microdevices for biological sample processing

Carlotta Guiducci, Pierre-Emmanuel Marie Thiriet, Gloria Porro, Till Jonathan Ryser

Microsystems combining fluid dynamics and electric-field-induced forces have emerged as powerful tools for manipulating and isolating biological species. Advances in electrokinetic theory, combined with optimized microfabrication processes, are at the core ...

Springer Science and Business Media LLC2024

A Comparative Study on Fabrication Techniques for On-Chip Microelectrodes

Yusuf Leblebici, Carlotta Guiducci, Yüksel Temiz, Anna Ferretti

This paper presents an experimental study on different microelectrode fabrication techniques, with particular focus on the robustness of the surface insulation towards typical working conditions required in lab-on-a-chip applications. Pt microelectrodes wi ...

Royal Society of Chemistry2012

More DNA–Aptamers for Small Drugs: A Capture–SELEX Coupled with Surface Plasmon Resonance and High-Throughput Sequencing

Carlotta Guiducci, Fabio Mario Spiga

To address limitations in the production of DNA aptamers against small molecules, we introduce a DNA-based capture-SELEX (systematic evolution of ligands by exponential enrichment) protocol with long and continuous randomized library for more flexibility, ...

ACS Publications2015

Post-CMOS Processing and 3-D Integration Based on Dry-Film Lithography

Yusuf Leblebici, Carlotta Guiducci, Yüksel Temiz

This paper presents a chip-level postcomplementary metal oxide semiconductor (CMOS) processing technique for 3-D integration and through-silicon-via (TSV) fabrication. The proposed technique is based on dry-film lithography, which is a low-cost and simple ...

Ieee-Inst Electrical Electronics Engineers Inc2013

Analysis of Dielectric Microbead Detection by Impedance Spectroscopy with Nanoribbons

Carlotta Guiducci, Enrico Accastelli

We present a quantitative numerical analysis of dielectric microbead detection experiments with nanoribbons operated in the AC small signal regime. To this purpose, a comprehensive model of nanoribbon operation in electrolyte environment and with DC/AC sig ...

Ieee2016

Device to carry out semiconductor-based diagnostics

Carlotta Guiducci, Saurabh Tomar

The present invention relates to a device to carry out semiconductor based molecular diagnostics comprising a microfluidic chip carrier 1, an elastomer microfluidic module 2 and a CMOS chip 3, one surface of said microfluidic module facing and contacting o ...

2022

A CMOS Compatible Chip-to-Chip 3D Integration Platform

Yusuf Leblebici, Carlotta Guiducci, Michail Zervas, Yüksel Temiz

In this paper, a CMOS-compatible chip-to-chip 3D integration platform will be presented. The developed technology allows reconstituting a wafer from diced and thinned chips. Then, chip-to-chip bonding and TSV fabrication steps are accomplished in wafer-lev ...

IEEE2012

Metal-coated silicon micropillars for freestanding 3D-electrode arrays in microchannels

Carlotta Guiducci, Samuel Kilchenmann, Elena Bianchi, Enrica Rollo

This paper presents a fabrication process for arrays of high-aspect-ratio micropillar electrodes, which are freestanding 3D structures that feature metal sidewalls connected to passivated planar wires. Facing vertical electrodes are considered to be a key ...

Elsevier2013

Rapid Multianalyte Microfluidic Homogeneous Immunoassay on Electrokinetically Driven Beads

Carlotta Guiducci, Pierre-Emmanuel Marie Thiriet, Gloria Porro, Danashi Imani Medagoda

The simplicity of homogeneous immunoassays makes them suitable for diagnostics of acute conditions. Indeed, the absence of washing steps reduces the binding reaction duration and favors a rapid and compact device, a critical asset for patients experiencing ...

2020

Integration of Ultra-Low Volume Pneumatic Microfluidics with a Three-Dimensional Electrode Network for On-Chip Biochemical Sensing

Carlotta Guiducci, Saurabh Tomar

This paper reports a novel miniaturized pseudo reference electrode (RE) design for biasing Ion Sensitive Field Effect Transistors (ISFETs). It eliminates the need for post-CMOS processing and can scale up in numbers with the CMOS scaling. The presented des ...

2021

Comparison between front- and back-gating of Silicon Nanoribbons in real-time sensing experiments

Carlotta Guiducci, Enrico Accastelli, Giulia Cappi

Field-effect transistors (FETs) with open gate structures such as Silicon Nanoribbons (SiNRs) are promising candidates to become general platforms for ultrasensitive, label-free and real-time detection of biochemical interactions on surface. This work prop ...

2013