Richardus Houtkooper

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Related publications (30)

In Vivo Modulation of Mitochondrial Activity Determines HSC Engraftment and Post-Transplant Survival in Mice

Matthias Lütolf, Aline Roch, Nicola Vannini, Johan Auwerx, Richardus Houtkooper, Mukul Girotra, Eija Riitta Pirinen, Olaia Maria Naveiras Torres-Quiroga, Vasco Ledebur de Antas de Campos

Amer Soc Hematology2012

Sleep In A Dish: Key Electrophysiological, Molecular, And Metabolic Signatures Of Sleep And Wakefulness Revealed In Primary Cortical Cultures

Cyril Mikhail, Johan Auwerx, Richardus Houtkooper

Amer Acad Sleep Medicine2012

Cardiac and Skeletal Muscle Defects in a Mouse Model of Human Barth Syndrome

Richardus Houtkooper

Barth syndrome is an X-linked genetic disorder caused by mutations in the tafazzin (taz) gene and characterized by dilated cardiomyopathy, exercise intolerance, chronic fatigue, delayed growth, and neutropenia. Tafazzin is a mitochondrial transacylase requ ...

2011

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

Johan Auwerx, Richardus Houtkooper, Dongryeol Ryu

Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (r ...

Cell Press2011

The dynamics of cardiolipin synthesis post-mitochondrial fusion

Richardus Houtkooper

Alteration in mitochondrial fusion may regulate mitochondrial metabolism. Since the phospholipid cardiolipin (CL) is required for function of the mitochondrial respiratory chain, we examined the dynamics of CL synthesis in growing Hela cells immediately af ...

2010

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria

Richardus Houtkooper

The BH3-only BID (BH3-interacting domain death agonist) protein has a critical function in the death-receptor pathway in the liver by triggering mitochondrial outer membrane permeabilization (MOMP). Here we show that MTCH2/MIMP (mitochondrial carrier homol ...

2010

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

Johan Auwerx, Carlos Canto Alvarez, Richardus Houtkooper

A century after the identification of a coenzymatic activity for NAD(+), NAD(+) metabolism has come into the spotlight again due to the potential therapeutic relevance of a set of enzymes whose activity is tightly regulated by the balance between the oxidi ...

Endocrine Society2010

Metabolic Networks of Longevity

Johan Auwerx, Richardus Houtkooper

Molecular and cellular networks implicated in aging depend on a multitude of proteins that collectively mount adaptive and contingent metabolic responses to environmental challenges. Here, we discuss the intimate links between metabolic regulation and long ...

2010

Obesity: New life for antidiabetic drugs

Johan Auwerx, Richardus Houtkooper

2010

The enigmatic role of tafazzin in cardiolipin metabolism

Richardus Houtkooper

The mitochondrial phospholipid cardiolipin plays an important role in cellular metabolism as exemplified by its involvement in mitochondrial energy production and apoptosis. Following its biosynthesis, cardiolipin is actively remodeled to achieve its final ...

2009

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