Publication

Mitochondrial ribosomal proteins as aging regulators

Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper
2013
Patents

Abstract

The present invention relates to methods of increasing lifespan, delaying aging, and/or preventing or treating an age-related disease or a mitochondrialdisease in a subject, comprising inducing a nuclear-mitochondrial OXPHOS protein dyssynchrony, including inhibiting the mitochondrial translation machinery function, as well as methods forscreening agents that are able to increase lifespan, inhibit or delay aging, and/or prevent or treat an age-related disease or disorder, or a mitochondrial disease or disorder, in a subject.

Official source

https://infoscience.epfl.ch/entities/publication/c508df2a-321a-4faf-8ae2-673daa34835e

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Mitochondrial ribosomal proteins as aging regulators

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