Publication

Confounding factors from inducible systems for spatiotemporal gene expression regulation

Johan Auwerx
2020
Journal Articles

Abstract

Spatiotemporally regulated targeted gene manipulation is a common way to study the effect of gene variants on phenotypic traits, but the Cre/loxP and Tet-On/Tet-Off systems can affect whole-organism physiology and function due to off-target effects. We highlight some of these adverse effects, including whole-body endocrinology and disturbances in the gut microbiome and in mitochondrial and metabolic function.

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Confounding factors from inducible systems for spatiotemporal gene expression regulation

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