Publications by Laura Symul | EPFL Graph Search

Related publications (7)

Genome-Wide RNA Polymerase II Profiles and RNA Accumulation Reveal Kinetics of Transcription and Associated Epigenetic Changes During Diurnal Cycles

Felix Naef, Nicolas Jean Philippe Guex, Olivier Martin, Mauro Delorenzi, Bart Deplancke, Jacques Rougemont, Laura Symul

Interactions of cell-autonomous circadian oscillators with diurnal cycles govern the temporal compartmentalization of cell physiology in mammals. To understand the transcriptional and epigenetic basis of diurnal rhythms in mouse liver genome-wide, we gener ...

Public Library Science2012

Non-Circadian Expression Masking Clock-Driven Weak Transcription Rhythms in U2OS Cells

Felix Naef, Laura Symul

U2OS cells harbor a circadian clock but express only a few rhythmic genes in constant conditions. We identified 3040 binding sites of the circadian regulators BMAL1, CLOCK and CRY1 in the U2OS genome. Most binding sites even in promoters do not correlate w ...

Public Library of Science2014

Assessment of menstrual health status and evolution through mobile apps for fertility awareness

Laura Symul, Marcel Salathé

For most women of reproductive age, assessing menstrual health and fertility typically involves regular visits to a gynecologist or another clinician. While these evaluations provide critical information on an individual's reproductive health status, they ...

Springer2019

Kinetic Analysis of Transcriptional and Post-Transcriptional Processes During Circadian Cycles

Laura Symul

Every morning the sun rises, flooding the earth with its light and heat and every night it disappears leaving the Earth in the darkness of the night. Organisms living on this planet have adapted to this solar rhythm and have spread their activities through ...

EPFL2013

Food & You: A digital cohort on personalized nutrition

Djilani James Kebaili, Harris Héritier, Laura Symul, Talia Elena Salzmann, Chloé Emmanuelle Allémann, Marcel Salathé, Yannis Gregory Romain Jaquet, Sean Francis Carroll, Oleksandr Balakiriev, Germain Nicolas Hugon, Rahel Maria Salathé, Peter Ian Michael De Verteuil, Noé Georges Froidevaux, Elif Ugurlu Baud, Victor Guy Boulanger, Sandra Riccardi, Rohan Singh

Nutrition is a key contributor to health. Recently, several studies have identified associations between factors such as microbiota composition and health-related responses to dietary intake, raising the potential of personalized nutritional recommendation ...

2023

The Circadian Clock Coordinates Ribosome Biogenesis

Felix Naef, Laura Symul, Frédéric Bruno Martin Gachon

Biological rhythms play a fundamental role in the physiology and behavior of most living organisms. Rhythmic circadian expression of clock-controlled genes is orchestrated by a molecular clock that relies on interconnected negative feedback loops of transc ...

Public Library Science2013

Differential regulation of RNA polymerase III genes during liver regeneration

Felix Naef, Philippe Jacquet, Nicolas Jean Philippe Guex, Jonathan Aryeh Sobel, Cristian Carmeli, Olivier Martin, Irina Krier, Mauro Delorenzi, Bart Deplancke, Jacques Rougemont, Laura Symul, Fabrice David, Sunil Kumar Raghav, Marion Leleu, Julia Catharina Cajan, Kyle Gustafson, Dominic Villeneuve

Mouse liver regeneration after partial hepatectomy involves cells in the remaining tissue synchronously entering the cell division cycle. We have used this system and H3K4me3, Pol II and Pol III profiling to characterize adaptations in Pol III transcriptio ...

Oxford University Press (OUP)2019