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Johan Auwerx

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Related publications (283)

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling

The formation of myelin by Schwann cells (SCs) occurs via a series of orchestrated molecular events. We previously used global expression profiling to examine peripheral nerve myelination and identified the NAD(+)-dependent deacetylase Sir-two-homolog 2 (S ...

2011

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

Johan Auwerx, Carlos Canto Alvarez, Richardus Houtkooper

A century after the identification of a coenzymatic activity for NAD(+), NAD(+) metabolism has come into the spotlight again due to the potential therapeutic relevance of a set of enzymes whose activity is tightly regulated by the balance between the oxidi ...

Endocrine Society2010

AMP-activated protein kinase and its downstream transcriptional pathways

Johan Auwerx, Carlos Canto Alvarez

The AMP-activated protein kinase (AMPK) is a key regulator of catabolic versus anabolic processes. Its properties as an energy sensor allow it to couple the energy status of the cell to the metabolic environment. These adaptations not only take place throu ...

Birkhäuser-Verlag, Springer2010

The Intestinal Nuclear Receptor Signature With Epithelial Localization Patterns and Expression Modulation in Tumors

Kristina Schoonjans, Johan Auwerx

BACKGROUND & AIMS: The WNT-adenomatous polyposis coli system controls cell fate in the intestinal epithelium, where compartment-specific genes tightly regulate proliferation, migration, and differentiation. Nuclear receptors are transcription factors funct ...

2010

The Pollutant Diethylhexyl Phthalate Regulates Hepatic Energy Metabolism via Species-Specific PPAR alpha-Dependent Mechanisms

Johan Auwerx

BACKGROUND: The modulation of energetic homeostasis by pollutants has recently emerged as a potential contributor to the onset of metabolic disorders. Diethylhexyl phthalate (DEHP) is a widely used industrial plasticizer to which humans are widely exposed. ...

2010

Clking on PGC-1alpha to inhibit gluconeogenesis

Johan Auwerx, Carlos Canto Alvarez

The link between Akt activation and gluconeogenic repression remains unclear, despite many years of investigation and remarkable progress. Rodgers and colleagues now introduce us to the Clk2 kinase, an Akt substrate that can directly phosphorylate and inhi ...

Cell Press2010

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

Johan Auwerx, Carlos Canto Alvarez, Chikage Mataki

During fasting and after exercise, skeletal muscle efficiently switches from carbohydrate to lipid as the main energy source to preserve glycogen stores and blood glucose levels for glucose-dependent tissues. Skeletal muscle cells sense this limitation in ...

Cell Press2010

Metabolic Networks of Longevity

Johan Auwerx, Richardus Houtkooper

Molecular and cellular networks implicated in aging depend on a multitude of proteins that collectively mount adaptive and contingent metabolic responses to environmental challenges. Here, we discuss the intimate links between metabolic regulation and long ...

2010

Obesity: New life for antidiabetic drugs

Johan Auwerx, Richardus Houtkooper

2010

PPAR gamma Ligands Switched High Fat Diet-Induced Macrophage M2b Polarization toward M2a Thereby Improving Intestinal Candida Elimination

Johan Auwerx

Obesity is associated with a chronic low-grade inflammation that predisposes to insulin resistance and the development of type 2 diabetes. In this metabolic context, gastrointestinal (GI) candidiasis is common. We recently demonstrated that the PPAR gamma ...

Public Library of Science2010

Histone methyl transferases and demethylases; can they link metabolism and transcription?

Kristina Schoonjans, Johan Auwerx

Heritable changes to the transcriptome that are independent to changes in the genome are defined as epigenetics. DNA methylation and posttranslational modifications of histones, such as acetylation/deacetylation and methylation/demethylation of lysine resi ...

Cell Press2010

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

Kristina Schoonjans, Johan Auwerx, Thijs Pols

Incretin-based therapies have shown promise in the treatment of type 2 diabetes. Here we review our current understanding of TGR5 as a target to induce glucagon-like peptide-1 (GLP-1) secretion. These new observations suggest that TGR5 agonists may constit ...

Elsevier Masson2010

Protein deacetylation by SIRT1: An emerging key post- translational modification in metabolic regulation

Johan Auwerx, Jiujiu Yu

The biological function of most proteins relies on reversible post-translational modifications, among which phosphorylation is most prominently studied and well recognized. Recently, a growing amount of evidence indicates that acetylation-deacetylation rea ...

Elsevier2010

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

Kristina Schoonjans, Johan Auwerx, Ellen Helena Jeninga

rganisms adapt their metabolism to meet ever changing environmental conditions. This metabolic adaptation involves at a cellular level the fine tuning of mitochondrial function, which is mainly under the control of the transcriptional co-activator prolifer ...

2010

Redefining the TGR5 triterpenoid binding pocket at the C-3 position

Kristina Schoonjans, Johan Auwerx

Wiley-Blackwell2010

The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface

Johan Auwerx

The metabolic impact of the common peroxisome proliferator-activated receptor gamma isoform 2 (PPARgamma2) variant Pro12Ala in human populations has been widely debated. We demonstrate, using a Pro12Ala knockin model, that on chow diet, Ala/Ala mice are le ...

Cell Press2009

Caloric restriction, SIRT1 and longevity

Johan Auwerx, Carlos Canto Alvarez

More than 70 years after its initial report, caloric restriction stands strong as the most consistent non- pharmacological intervention increasing lifespan and protecting against metabolic disease. Among the different mechanisms by which caloric restrictio ...

2009

AMPK regulates energy expenditure by modulating NAD(+) metabolism and SIRT1 activity

Johan Auwerx, Lilia Noriega Lopez, Carlos Canto Alvarez

AMP-activated protein kinase (AMPK) is a metabolic fuel gauge conserved along the evolutionary scale in eukaryotes that senses changes in the intracellular AMP/ATP ratio. Recent evidence indicated an important role for AMPK in the therapeutic benefits of m ...

2009

The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice

Kristina Schoonjans, Johan Auwerx

Studies in rodents have shown that male sexual function can be disrupted by fetal or neonatal administration of compounds that alter endocrine homeostasis, such as the synthetic nonsteroidal estrogen diethylstilbestrol (DES). Although the molecular basis f ...

American Society for Clinical Investigation2009

PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

Johan Auwerx, Carlos Canto Alvarez

PURPOSE OF REVIEW: Peroxisome proliferator-activated receptor gamma coactivator-1-alpha (PGC-1alpha) has been extensively described as a master regulator of mitochondrial biogenesis. However, PGC-1alpha activity is not constant and can be finely tuned in r ...

2009

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