Publication

Clking on PGC-1alpha to inhibit gluconeogenesis

Johan Auwerx, Carlos Canto Alvarez
2010
Reviews

Abstract

The link between Akt activation and gluconeogenic repression remains unclear, despite many years of investigation and remarkable progress. Rodgers and colleagues now introduce us to the Clk2 kinase, an Akt substrate that can directly phosphorylate and inhibit PGC-1alpha, blunting hepatic glucose production.

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Clking on PGC-1alpha to inhibit gluconeogenesis

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