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Kristina Schoonjans

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Related publications (103)

Page 5 of 6

Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity

Kristina Schoonjans, Alessia Perino

Bile acids (BAs) improve metabolism and exert anti-obesity effects through the activation of the Takeda G protein-coupled receptor 5 (TGR5) in peripheral tissues. TGR5 is also found in the brain hypothalamus, but whether hypothalamic BA signaling is implic ...

Cell Press2021

De novo NAD(+) synthesis enhances mitochondrial function and improves health

Johan Auwerx, Kristina Schoonjans, Dongryeol Ryu, Adrienne Joëlle Laurence Mottis, Elena Katsyuba, Karim Laurent Gariani, Olli Juhani Matilainen, Marika Olga Zietak

Nicotinamide adenine dinucleotide (NAD(+)) is a co-substrate for several enzymes, including the sirtuin family of NAD(+)-dependent protein deacylases. Beneficial effects of increased NAD(+) levels and sirtuin activation on mitochondrial homeostasis, organi ...

NATURE PUBLISHING GROUP2018

Metabolic Characterization of a Sirt5 deficient mouse model

Johan Auwerx, Kristina Schoonjans, Norman Lionel Moullan, Lilia Noriega Lopez, Jiujiu Yu

Sirt5, localized in the mitochondria, is a member of sirtuin family of NAD(+)-dependent deacetylases. Sirt5 was shown to deacetylate and activate carbamoyl phosphate synthase 1. Most recently, Sirt5 was reported to be the predominant protein desuccinylase ...

Nature Publishing Group2013

A microbial-derived succinylated bile acid to safeguard liver health

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny

In this issue of Cell, Nie and co-authors report that the microbe-derived bile acid (BA) 3-succinylated cholic acid protects against the progression of metabolic dysfunction-associated liver disease. Intriguingly, its protective mechanism does not involve ...

Cell Press2024

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Dongryeol Ryu, Hongbo Zhang, Giuseppe Lo Sasso

Mitochondrial activity is controlled by proteins encoded by both nuclear and mitochondrial DNA. Here, we identify Sirt7 as a crucial regulator of mitochondrial homeostasis. Sirt7 deficiency in mice induces multisystemic mitochondrial dysfunction, which is ...

Cell Press2014

Redefining the TGR5 triterpenoid binding pocket at the C-3 position

Johan Auwerx, Kristina Schoonjans

Wiley-Blackwell2010

Protecting liver health with microbial-derived succinylated bile acids

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny

The gut microbiome produces a plethora of metabolites that influence host metabolism. In a recent article published in Cell, Nie and colleagues reveal that 3-succinylated cholic acid, a microbe-derived bile acid, protects against metabolic dysfunction-asso ...

OXFORD UNIV PRESS2024

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

Johan Auwerx, Kristina Schoonjans, Thijs Pols

Incretin-based therapies have shown promise in the treatment of type 2 diabetes. Here we review our current understanding of TGR5 as a target to induce glucagon-like peptide-1 (GLP-1) secretion. These new observations suggest that TGR5 agonists may constit ...

Elsevier Masson2010

An antibiotic and a microorganism having bile acid 7α-dehydroxylation activity for treating non-infectious diseases

Kristina Schoonjans, Alessia Perino, Antoine Jalil

The present invention relates to one or more antibiotic(s) that disrupt(s) the microbial balance of the gut and a microorganism having bile acid 7α-dehydroxylation activity for use in the treatment of a non-infectious disease in a subject. ...

2024

TGR5, bile acids and the metabolic syndrome

Kristina Schoonjans

Federation Amer Soc Exp Biol2013

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

Johan Auwerx, Bernard Schneider, Kristina Schoonjans, Graham Knott, Hao Li, Adrienne Joëlle Laurence Mottis, Vincenzo Sorrentino, Davide D'Amico, Mario Romani, Vera Monica Lemos Da Silva

Little information is available about how post-transcriptional mechanisms regulate the aging process. Here, we show that the RNA-binding protein Pumilio2 (PUM2), which is a translation repressor, is induced upon aging and acts as a negative regulator of li ...

CELL PRESS2019

Role of TGR5 in fat-to-liver communication during NAFLD

Kristina Schoonjans, Alessia Perino

ELSEVIER2023

The bile acid receptor TGR5 regulates the hematopoietic support capacity of the bone marrow niche

Dominique Pioletti, Kristina Schoonjans, Alessia Perino, Ulrike Kettenberger, Frédérica Schyrr, Antoine Jalil, Alejandro Alonso Calleja, Vasiliki Delitsikou

Smw Supporting Association2023

The Bile Acid Receptor Tgr5 Regulates The Composition And Hematopoietic Support Capacity Of The Bone Marrow Microenvironment

Kristina Schoonjans, Alessia Perino, Frédérica Schyrr, Antoine Jalil, Alejandro Alonso Calleja, Vasiliki Delitsikou

ELSEVIER SCIENCE INC2023

Targeting bile-acid signalling for metabolic diseases

Johan Auwerx, Kristina Schoonjans

Bile acids are increasingly being appreciated as complex metabolic integrators and signalling factors and not just as lipid solubilizers and simple regulators of bile-acid homeostasis. It is therefore not surprising that a number of bile-acid-activated sig ...

2008

Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis

Kristina Schoonjans

Women with intrahepatic cholestasis of pregnancy (ICP), a disorder characterised by raised serum bile acids, are at increased risk of developing gestational diabetes mellitus and have impaired glucose tolerance whilst cholestatic. FXR and TGR5 are modulato ...

Nature Research2020

Women in Metabolism: Part I

Kristina Schoonjans

Cell Press2015

Molecular physiology of bile acid signaling in health, disease, and aging

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny, Laura Alejandra Velazquez Villegas

Over the last two decades, bile acids (BAs) have become established as important signaling molecules that enable fine-tuned inter-tissue communication from the liver, their site of production, over the intestine, where they are modified by the gut microbio ...

2021

TGR5 in macrophages is protective against atherosclerosis and insulin resistance

Johan Auwerx, Kristina Schoonjans, Thijs Pols, Mitsunori Nomura

Wiley-Blackwell2012

Bile acids after bariatric surgery: a gateway to mitochondrial activation in human adipocytes

Kristina Schoonjans, Alessia Perino

SPRINGER2022