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Kristina Schoonjans

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Related publications (103)

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SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport

Kristina Schoonjans, Alessia Perino, Dongryeol Ryu, Keir Joe Menzies, Xu Wang, Vera Monica Lemos Da Silva, Maaike Hélène Oosterveer, Pan Xu, Chikage Mataki

Reverse cholesterol transport (RCT) is an antiatherogenic process in which excessive cholesterol from peripheral tissues is transported to the liver and finally excreted from the body via the bile. The nuclear receptor liver receptor homolog 1 (LRH-1) driv ...

Cell Press2014

LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPAR gamma ligand synthesis

Kristina Schoonjans

Liver receptor homologue-1 (LRH-1) is a nuclear receptor involved in the repression of inflammatory processes in the hepatointestinal tract. Here we report that LRH-1 is expressed in macrophages and induced by the Th2 cytokine IL-13 via a mechanism involvi ...

Nature Publishing Group2015

Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity

Johan Auwerx, Kristina Schoonjans

Sirtuin 3 (SIRT3) is a protein deacetylase regulating beta-cell function through inhibiting oxidative stress in obese and diabetic mice, but the detailed mechanism and potential effect of beta-cell-specific SIRT3 on metabolic homeostasis, and its potential ...

AMER DIABETES ASSOC2021

Molecular basis for the regulation of the nuclear receptor LRH-1

Kristina Schoonjans

Liver receptor homolog-1 (LRH-1) is a nuclear receptor (NR) with diverse functions in development, differentiation and metabolism and has been extensively studied in the enterohepatic system. While initially described as an orphan NR, recent studies sugges ...

Current Biology Ltd2015

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

Maaike Hélène Oosterveer, Johan Auwerx, Kristina Schoonjans, Taoufiq Harach, Mitsunori Nomura, Thijs Pols, Giuseppe Lo Sasso

The G protein-coupled receptor TGR5 has been identified as an important component of the bile acid signaling network, and its activation has been linked to enhanced energy expenditure and improved glycemic control. Here, we demonstrate that activation of T ...

Cell Press2011

Hepatic glucose sensing and integrative pathways in the liver

Kristina Schoonjans, Maaike Hélène Oosterveer

The hepatic glucose-sensing system is a functional network of enzymes and transcription factors that is critical for the maintenance of energy homeostasis and systemic glycemia. Here we review the recent literature on its components and metabolic actions. ...

Springer Basel Ag2014

Three dimensional models of tissue fibrosis

Kristina Schoonjans, Matthias Lütolf, Saba Rezakhani, Giovanni Sorrentino, Ece Yildiz

The invention provides a method for obtaining a three-dimensional (3D) cellular model of tissue fibrosis, such as liver fibrosis, comprising culturing epithelial cells in a 3D hydrogel in conditions suitable for a three-dimensional cellular cluster formati ...

2020

NR5A2 Regulates Lhb and Fshb Transcription in Gonadotrope-Like Cells In Vitro, but Is Dispensable for Gonadotropin Synthesis and Fertility In Vivo

Johan Auwerx, Kristina Schoonjans

Successful mammalian reproduction depends on proper synthesis of the pituitary-derived glycoprotein hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Several transcription factors cooperate to activate cell-specific and hormone-reg ...

Public Library of Science2013

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

Johan Auwerx, Kristina Schoonjans, Laurent Mouchiroud, Alessandra Piersigilli, Dongryeol Ryu, Elena Katsyuba, Giuseppe Lo Sasso

Dysfunction of Paneth and goblet cells in the intestine contributes to inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Here, we report a role for the NAD+-dependent histone deacetylase SIRT1 in the control of anti-bacterial ...

Public Library of Science2014

Phosphorylation of the nuclear receptor co-repressor 1 by protein kinase B (PKB/Akt) switches its co-repressor targets in the liver

Johan Auwerx, Kristina Schoonjans, Dongryeol Ryu, Xu Wang, Adriano Maida

The nuclear receptor corepressor 1 (NCoR1) is a transcriptional co-regulator that has wide-ranging effects on gene expression patterns. In the liver, NCoR1 represses lipid synthesis in the fasting state, whereas it inhibits the activation of PPARα upon fee ...

Wiley-Blackwell2015

A multiscale study of the role of dynamin in the regulation of glucose uptake

Martinus Adela Maria Gijs, Johan Auwerx, Kristina Schoonjans, Laurent Mouchiroud, Raphaël Etienne Jean Trouillon, Keir Joe Menzies, Maria Cristina Letizia

Glucose uptake in muscle cells in response to insulin is a fundamental mechanism for metabolism. The inability of cells to mobilize the specific glucose transporter GLUT4 is believed to be at least partially accountable for diseases, like diabetes, where c ...

Royal Soc Chemistry2017

LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer

Johan Auwerx, Arnaud Comment, Kristina Schoonjans, Dongryeol Ryu, Norman Lionel Moullan, Emine Can, Xu Wang, Maaike Hélène Oosterveer, Pan Xu, Hadrien Charles Edouard Demagny

Various tumors develop addiction to glutamine to support uncontrolled cell proliferation. Here we identify the nuclear receptor liver receptor homolog 1 (LRH-1) as a key regulator in the process of hepatic tumorigenesis through the coordination of a noncan ...

Cold Spring Harbor Laboratory2016

Wars1 downregulation in hepatocytes induces mitochondrial stress and disrupts metabolic homeostasis

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Xiaoxu Li, Giorgia Benegiamo, Hadrien Charles Edouard Demagny, Antoine Jalil, Francesca Pontanari, Adrien Faure Garcia

Several laboratories, including ours, have employed the Slc25a47tm1c(EUCOMM)Hmgu mouse model to investigate the role of SLC25A47, a hepatocyte-specific mitochondrial carrier, in regulating hepatic metabolism and systemic physiology. In this study, we revea ...

2025

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

Johan Auwerx, Matthias Lütolf, Kristina Schoonjans, Dongryeol Ryu, Hongbo Zhang, Davide D'Amico, Keir Joe Menzies, Xu Wang, Karim Laurent Gariani, Peiling Luan

Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD(+)) and its imp ...

American Association for the Advancement of Science2016

Identifying gene function and module connections by the integration of multispecies expression compendia

Johan Auwerx, Stephan Morgenthaler, Kristina Schoonjans, Maroun Bou Sleiman, Yang Li, Elena Katsyuba, Hao Li, Fabrice David, Wen Gao, Qingyao Huang, Changmyung Oh, Daria Rukina

The functions of many eukaryotic genes are still poorly understood. Here, we developed and validated a new method, termed GeneBridge, which is based on two linked approaches to impute gene function and bridge genes with biological processes. First, Gene-Mo ...

Cold Spring Harbor Laboratory2019

Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma

Johan Auwerx, Kristina Schoonjans, Pan Xu

Aims: Sirtuin 7 (SIRT7) plays an important role in tumor development, and has been characterized as a potent regulator of cellular stress. However, the effect of SIRT7 on sorafenib acquired resistance remains unclear and a possible anti-tumor mechanism bey ...

2024

Dietary Fiber Is Essential to Maintain Intestinal Size, L-Cell Secretion, and Intestinal Integrity in Mice

Kristina Schoonjans

Dietary fiber has been linked to improved gut health, yet the mechanisms behind this association remain poorly understood. One proposed mechanism is through its influence on the secretion of gut hormones, including glucagon-like peptide-1 (GLP-1) and gluca ...

FRONTIERS MEDIA SA2021

Another Shp on the Horizon for Bile Acids

Kristina Schoonjans, Alessia Perino

Bile acid metabolism is tightly controlled due to the toxic effects of bile acid overload. In this issue, research from the Feng lab reports Shp2 as a novel integrator of hepatic bile acid and FGF15/FGF19 signaling, adding another layer of complexity to th ...

Cell Press2014

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

Kristina Schoonjans, Alessia Perino

Bile acids are signalling molecules, which activate the transmembrane receptor TGR5 and the nuclear receptor FXR. BA sequestrants (BAS) complex bile acids in the intestinal lumen and decrease intestinal FXR activity. The BAS-BA complex also induces glucago ...

Nature Publishing Group2015

The G Protein-Coupled Bile Acid Receptor TGR5 (Gpbar1) Modulates Endothelin-1 Signaling in Liver

Kristina Schoonjans

TGR5 (Gpbar1) is a G protein-coupled receptor responsive to bile acids (BAs), which is expressed in different non-parenchymal cells of the liver, including biliary epithelial cells, liver-resident macrophages, sinusoidal endothelial cells (LSECs), and acti ...

2019