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Ute Koch

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Related publications (34)

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A third Notch in colorectal cancer progression and metastasis

Freddy Radtke, Ute Koch

In this issue of JEM, Varga et al. (https://doi.org/10.1084/jem.20191515) describe a mouse model of invasive and metastatic colorectal cancer (CRC) closely resembling the human consensus molecular subtype (CMS) 4 associated with the poorest overall surviva ...

ROCKEFELLER UNIV PRESS2020

Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation

Freddy Radtke, Ute Koch

A better understanding of the mechanisms regulating CD8+ T cell differentiation is essential to develop new strategies to fight infections and cancer. Using genetic mouse models and blocking antibodies, we uncovered cellular and molecular mechanisms by whi ...

ROCKEFELLER UNIV PRESS2025

Notch Signaling Regulates the Homeostasis of Tissue-Restricted Innate-like T Cells

Freddy Radtke, Ute Koch

Although Notch signaling plays important roles in lineage commitment and differentiation of multiple cell types including conventional T cells, nothing is currently known concerning Notch function in innate-like T cells. We have found that the homeostasis ...

American Association of Immunologists ; Oxford University Press2016

Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis

Freddy Radtke, Ute Koch

Hematopietic stem cells (HSCs) maintain life-long hematopoiesis in the bone marrow via their ability to self-renew and to differentiate into all blood lineages. Although a central role for the canonical wnt signaling pathway has been suggested in HSC self- ...

2008

Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells

Freddy Radtke, Ute Koch

Gain-of-function experiments have demonstrated the potential of Notch signals to expand primitive hematopoietic progenitors, but whether Notch physiologically regulates hematopoietic stem cell (HSC) homeostasis in vivo is unclear. To answer this question, ...

2008

Stem cells living with a Notch

Freddy Radtke, Ute Koch, Rajwinder Lehal

Notch signaling has been shown over the past few decades to play fundamental roles in a plethora of developmental processes in an evolutionarily conserved fashion. Notch-mediated cell-to-cell signaling is involved in many aspects of embryonic development a ...

Company of Biologists2013

Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis

Freddy Radtke, Ute Koch

Self-renewal and differentiation of stem and progenitor cells are tightly regulated to ensure tissue homeostasis. This regulation is enabled both remotely by systemic circulating cues, such as cytokines and hormones, and locally by various niche-confined f ...

ELSEVIER2023

Dll1- and Dll4-mediated Notch signaling is required for homeostasis of intestinal stem cells

Freddy Radtke, Ute Koch, Luca Pellegrinet

BACKGROUND & AIMS: Ablation of Notch signaling within the intestinal epithelium results in loss of proliferating crypt progenitors, due to their conversion into post-mitotic secretory cells. We aimed to confirm that Notch was active in stem cells (SC), inv ...

2011

Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelia lineage in fetal thymus development

Freddy Radtke, Ute Koch, Dong Liu

Thymus function depends on the epithelial compartment of the thymic stroma. Cortical thymic epithelial cells (cTECs) regulate T cell lineage commitment and positive selection, while medullary (m) TECs impose central tolerance on the T cell repertoire. Duri ...

2020

Signalling strength determines proapoptotic functions of STING

Freddy Radtke, Andrea Ablasser, Ute Koch, Muhammet Fatih Gülen

Mammalian cells use cytosolic nucleic acid receptors to detect pathogens and other stress signals. In innate immune cells the presence of cytosolic DNA is sensed by the cGAS-STING signalling pathway, which initiates a gene expression programme linked to ce ...

Springer Nature2017

Notch Signaling Regulates Follicular Helper T Cell Differentiation

Freddy Radtke, Ute Koch, Nicolas Fasnacht

Follicular helper T (TFH) cells are specialized in providing help for B cell differentiation and Ab secretion. Several positive and negative regulators of TFH cell differentiation have been described but their control is not fully understood. In this study ...

American Association of Immunologists ; Oxford University Press2013

Stroma-Driven Notch2 Signaling Controls Naive B Cell Fate By Regulating Microenvironmental Positioning within the Spleen

Freddy Radtke, Ute Koch

Amer Soc Hematology2023

Notch Signaling In Normal And Malignant T-Cells

Freddy Radtke, Ute Koch, Rajwinder Lehal, Fabian Junker, Caroline Poisson

Elsevier Science Inc2012

Donor T Cells Require Notch Signals but Not Alloantigen Presentation from Specialized Secondary Lymphoid Organ Fibroblasts to Drive Graft-Versus-Host Disease

Freddy Radtke, Ute Koch

AMER SOC HEMATOLOGY2018