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Ute Koch

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Publications associées (37)

DL4-mediated Notch signaling is required for the development of fetal alpha beta and gamma delta T cells

Stéphanie Claudinot, Freddy Radtke, Ute Koch

T-cell development depends upon interactions between thymocytes and thymic epithelial cells (TECs). The engagement of delta-like 4 (DL4) on TECs by Notch1 expressed by blood-borne BM-derived precursors is essential for T-cell commitment in the adult thymus ...

Wiley2013

Loss of Cutaneous TSLP-Dependent Immune Responses Skews the Balance of Inflammation from Tumor Protective to Tumor Promoting

Freddy Radtke, Ute Koch, Matteo Di Piazza, Craig Nowell

Inflammation can promote or inhibit cancer progression. In this study we have addressed the role of the proinflammatory cytokine thymic stromal lymphopoietin (TSLP) during skin carcinogenesis. Using conditional loss- and gain-of-function mouse models for N ...

Elsevier2012

Transcription factor ROR alpha is critical for nuocyte development

Freddy Radtke, Ute Koch

Nuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct, previously ...

2012

Activation of a glioma-specific immune response by oncolytic parvovirus Minute Virus of Mice infection

Ute Koch

Rodent autonomous parvoviruses (PVs) are endowed with oncotropic properties and represent virotherapeutics with inherent oncolytic features. This work aimed to evaluate the capacity of Minute Virus of Mice (MVMp) to act as an adjuvant stimulating a mouse g ...

2012

Notch Signaling In Normal And Malignant T-Cells

Freddy Radtke, Rajwinder Lehal, Caroline Poisson, Ute Koch, Fabian Junker

Elsevier Science Inc2012

Dll1- and Dll4-mediated Notch signaling is required for homeostasis of intestinal stem cells

Freddy Radtke, Luca Pellegrinet, Ute Koch, Shuang Chen

BACKGROUND & AIMS: Ablation of Notch signaling within the intestinal epithelium results in loss of proliferating crypt progenitors, due to their conversion into post-mitotic secretory cells. We aimed to confirm that Notch was active in stem cells (SC), inv ...

2011

Notch Signaling In Solid Tumors

Freddy Radtke, Ute Koch

In recent years a substantial body of evidence derived from not only preclinical but also clinical studies has accumulated in support of Notch signaling playing important oncogenic roles in several types of cancer. The finding that activating Notch mutatio ...

2010

Hes1 Is a Critical but Context-Dependent Mediator of Canonical Notch Signaling in Lymphocyte Development and Transformation

Freddy Radtke, Agnieszka Anna Wendorff, Ute Koch, Christelle Dubey, Silvia Wirth

Although canonical Notch signaling regulates multiple hematopoietic lineage decisions including T cell and marginal zone B cell fate specification, the downstream molecular mediators of Notch function are largely unknown. We showed here that conditional in ...

Elsevier2010

Hedgehog signaling is dispensable for adult hematopoietic stem cell function

Freddy Radtke, Ute Koch, Shuai Liu

The Hedgehog (Hh) signaling pathway is a developmentally conserved regulator of stem cell function. Several reports suggested that Hh signaling is an important regulator of hematopoietic stem cell (HSC) maintenance and differentiation. Here we test this hy ...

2009

Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies

Freddy Radtke, Floriane Auderset, Ute Koch, Anne Wilson

It is well established that Notch signaling plays a critical role at multiple stages of T cell development and activation. However, detailed analysis of the cellular and molecular events associated with Notch signaling in T cells is hampered by the lack of ...

2009

Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis

Freddy Radtke, Ute Koch, Anne Wilson

Hematopietic stem cells (HSCs) maintain life-long hematopoiesis in the bone marrow via their ability to self-renew and to differentiate into all blood lineages. Although a central role for the canonical wnt signaling pathway has been suggested in HSC self- ...

2008

Correction to “Notch and cancer: a double-edged sword”

Freddy Radtke, Ute Koch

Springer, SP Birkhäuser Verlag Basel2008

Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells

Freddy Radtke, Ute Koch

Gain-of-function experiments have demonstrated the potential of Notch signals to expand primitive hematopoietic progenitors, but whether Notch physiologically regulates hematopoietic stem cell (HSC) homeostasis in vivo is unclear. To answer this question, ...

2008

Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment

Alexandre José Pessanha De Oliveira Caimoto Duarte, Freddy Radtke, Ute Koch

Thymic T cell lineage commitment is dependent on Notch1 (N1) receptor-mediated signaling. Although the physiological ligands that interact with N1 expressed on thymic precursors are currently unknown, in vitro culture systems point to Delta-like 1 (DL1) an ...

2008

Notch and cancer: a double-edged sword

Freddy Radtke, Ute Koch

Springer, SP Birkhäuser Verlag Basel2007

Haematopoietic stem cell niche in Drosophila

Freddy Radtke, Ute Koch

Development and homeostasis of the haematopoietic system is dependent upon stem cells that have the unique ability to both self-renew and to differentiate in all cell lineages of the blood. The crucial decision between haematopoietic stem cell (HSC) self-r ...

2007

Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation

Freddy Radtke, Ute Koch

Notch1 (N1) receptor signaling is essential and sufficient for T cell development, and recently developed in vitro culture systems point to members of the Delta family as being the physiological N1 ligands. We explored the ability of Delta1 (DL1) and DL4 t ...

2007

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